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Latest News Welcome to our corporate news page! Here, you can stay up-to-date with the latest news, innovations, and achievements of our company. From product launches and industry insights to events and company culture, we strive to keep you informed on all aspects of our business. Check back often for fresh updates and exciting news! For more updates and announcements, please follow us on LinkedIn Follow us on Linkedin CEHTRA's Expert Insights at Rentrée du DM 2023 ! Learn about CEHTRA's regulatory intelligence and specialized toxicology services in an exclusive interview. Discover how their expertise spans various sectors and integrates regulatory insights. Join us at Rentrée du DM 2022 on Oct 10 & 11 to explore CEHTRA's comprehensive offerings. July 20th, 2023 Join the QuAC Task Force for PT1 and PT2 - Save Time and Resources! Join CEHTRA's QuAC Task Force for PT1 and PT2 dossiers, a practical and cost-efficient solution. Benefit from our expertise in the Biocides sector. Contact Sandra Martinez Bosch ( sandra.martinez.bosch@cehtra.com ) for details and to join now! July 13th, 2023 European Commission's REACH Committee Votes to Restrict Microplastics European Commission's REACH Committee has approved a proposal to restrict the use of microplastics. The proposal is now under review by the European Parliament and Council. If you're unsure about the impact on your business, our experts can assist with regulatory challenges. Contact Stéphane PIERRE at stephane.pierre@cehtra.com . July 11th, 2023 Discover our latest video on Plant Protection at CEHTRA! Estelle Beltran introduces our expertise in the plant protection sector. If you have any questions, feel free to contact us at estelle.beltran@cehtra.com . July 6th, 2023 Webinar: Regulatory Compliance for Recycled Plastics in Food Contact Applications Join us for an informative webinar led by Caroline Opitz from CEHTRA. Learn about the regulations governing recycled plastics in food contact packaging in Europe and the USA. Gain insights into validation processes and ensure compliance. June 29th, 2023

Platform for Regulatory Intelligence, Supercollective, Multimarkets dedicated to the regulatory toxicology and ecotoxicology business community Already a member? Login Wish to create a new account? Register Get started! User Guide | Podcasts | FAQs First Collective Intelligence platform dedicated to the regulatory affairs community for product safety Designed in collaboration with Hypermind , PRISM is a collective intelligence-based platform allowing: a) to predict reliably and with high accurary, the foresights across multiple regulatory sectors including Biocides, Cosmetics, Plant Protection, REACH among others... b) to help industry better understand the impact of any upcoming regulatory changes and allow them to adapt its business strategy accordingly. Why is CEHTRA launching PRISM? CEHTRA is committed in a process to become a social economy company and has already established Collective Intelligence as its primary value. PRISM contributes to organizing and optimizing Collective Intelligence of our business community, better forecasting, better decision making and more innovation to commit responsibly to the challenges that the planet is facing to behave as an active player in tomorrow’s life. Why participate? To access new data and understand the foresights of our community. Whether you are an expert or have limited experience, every prediction counts. Experts tend to place more emphasis on science, while less experienced forecasters tend to better take into account all interference, of whatever nature. This is the very engine of collective intelligence. There are nudges for the best forecasters. Their ranking is also accessible in real time. Finally, we plan to build a panel of "superforecasters". What type of questions are asked? 1. Open questions To generate and select ideas For example : All participants are welcomed to propose ideas for questions. The ideas most likely to succeed are retained. 2. Closed questions To make predictions among different options (optimizing collective forecasts) For example: Multiple choice questions What makes PRISM unique? Unlike other surveys averaging uninformed opinions, PRISM applies sophisticated statistical tools and processes which comply strictly with the collective intelligence principles, grounded in most recent research in cognitive science and behavioral economy Be a part of PRISM to believe it yourself! PRISM User Guide Ready to join? Create your PRISM account User Guide Download PDF (English) Already a forecaster? Login to your PRISM account Watch PRISM video guide PRISM Podcasts Got questions? Get in touch with our team FAQs page - PRISM Podcasts

CEHTRA ensures the safety and conformity of your substances and plant protection products. Our experts help you to meet regulatory requirements: approval and authorisation dossiers, data gap analysis, toxicological and environmental risk assessments, and endocrine disrupting (ED) properties. Top of the page Description PLANT PROTECTION Description Contact Key Services Biocontrol Value-added Trainings Media As a manufacturer or a distributor in the field of agriculture, you want to get your substances approved efficiently and get your Plant Protection Products on the market. From Data Gap Analysis through to the dossier submission to the competent authorities, CEHTRA's team supports you in the necessary steps to meet the current regulatory requirements, for a successful registration. Contact Meet our experts Estelle BELTRAN Head of Plant Protection estelle.beltran@cehtra.com Blandine JOURNEL Expert Ecotoxicologist blandine.journel@cehtra.com Key Services Value-added Key Services Regulatory Dossiers From registration strategy up to the post-submission defense Data Gap Analysis Testing proposal Study monitoring Hazard identification Scientific rationale Risk Assessment Toxicology Consumer Environment Ecotox Modelling and refinement Task Force Management Management support to facilitate joint applications in the EU and abroad Value-added Services Endocrine Disrupting Properties CADDY and IUCLID dossiers Biocontrol Diagnostic Fertilizers and Biostimulants Environmental Screening Tailored studies (operator, field) Authorization of formulated products (including North and South America) Trainings Trainings Plant Protection Products: from regulation to registration en savoir plus s'inscrire 24 Mars 2025 Regulatory ecotoxicology: from the appropriate conduct of studies to environmental risk assessment en savoir plus s'inscrire Media Flyers Media Related Sectors Simply Predict Haut de page

CEHTRA offers customized and cost-effective Global Chemicals Notification services to ensure regulatory compliance for chemicals in various countries. Our experts use PRIMO and provide scientific expertise, testing programs, and country-compliant dossier preparation. Top of the page GLOBAL CHEMICALS NOTIFICATION Description Contact Key Services Value-added Media When it comes to chemical regulatory compliance, there is no ‘one method fits all’ approach. Here at CEHTRA we have developed our own internal tools designed to provide you the best worldwide, customized, and optimized strategy for a minimum cost. Our expert practitioners have collectively decades of experience and using our PRIMO tool are able to identify the most up to date regulatory requirements for the designated target countries. We prepare the Master dossier on which all other submissions are based. When required, our partners, chosen for their geographic proximity, language, and culture have the skills to prepare your local submission dossiers. Meet our experts Mathieu ROLLAND Head of Global Notifications mathieu.rolland@cehtra.com Damien GUYOMAR Toxicologist damien.guyomar@cehtra.com Melanie HARPER Regulatory Affairs Specialist melanie.harper@cehtra.com Description Contact Key Services Global Registration Strategies Registration schemes adapted to your needs Scientific Expertise Data Gap analysis Testing strategy (incl. alternatives to in vivo testing) Scientific support Testing Programme Monitor testing adapted to local requirements Registration Dossiers Preparation of Country-compliant dossiers Communication with authorities Value-added Services PRIMO tool to optimize management and follow-up of complex worldwide registration projects Scientific and Regulatory expert advices Only Representative services Countries Covered Please click on the highlighted country names to get redirected to their dedicated page on our website Australia Canada China EU countries South Korea Switzerland Taiwan Thailand India Japan Philippines Russia Turkey UK USA Others on application Key Services Value-added Media Flyers Tools CEHTRAcker CEHTRA's window to worldwide regulatory support Media Related Sectors Chemicals (REACH) Industrial Hygiene Simply Predict REACH Authorisation Haut de page

CEHTRA ensures the regulatory compliance of your packaging. Our experts can assist you with your declarations of conformity and with the risk assessment of your products. Our offer extends to laboratory testing, migration modeling and toxicological expertise. Top of the page PACKAGING Description Contact Key Services Value-added Trainings Media As a manufacturer, user of packaging or supplier for packaging manufacturing, you are facing regulatory issues? For the safety of your packaging substances & products, our team of expert with over a decade of experience can assist you with : Study of your documentation: declaration of compliance, regulatory statements Compliance of restricted substances thanks to an internal tool using mathematic modeling Monitoring of analysis with external laboratories Evaluation of worldwide regulatory requirements for packaging Click here to learn more... New ! Stay Ahead of Substance Migration with SF PP3 and CEHTRAPACK Tools ! Description Contact Meet our expert Caroline Opitz Head of Packaging caroline.opitz@cehtra.com Stephane PIERRE Managing Director of Paris Agency stephane.pierre@cehtra.com Key Services Regulatory / safety watch Customized text list Toxicological and regulatory substance watch Mapping by material / geographical area Regulatory / safety support Collection of supplier data Specifications Declarations of conformity Specific topics Global support Conduct of laboratory tests Multi-market support Food Pharmaceutica Medical Cosmetics Migration modeling Interactions between packaging and contained products: cosmetics and food By calculation By mathematical modeling Risk assessment of various materials : plastics, papers and boards, adhesives, inks, varnishes, metals, glass… Regulatory support on international regulations relative to food contact : EU, USA, Switzerland, China, Mercosur… Editing regulatory specifications and collecting informations from suppliers, documentary diagnosis, help in creation of Declaration of Compliance Compliance of restricted substances thanks to an internal tool using mathematic modeling, advices and monitoring of external lab tests when necessary Pragmatic approach to avoid expensive migration or extraction testsExpertise toxicologique Toxicological expertise Food contact courses We adapt our offer to the customer’s need Key Services Value-added Value-added Services Training offer Regulatory watch Regulatory and toxicological support Dedicated suppor t Packaging data management Migration / release assessment tools Trainings Trainings 25 Mars 2025 Regulations in Europe and the USA for recycled plastics intended for contact with food and in cosmetics en savoir plus s'inscrire 10 Juin 2025 Introduction to packaging regulations: understanding and implementing them en savoir plus s'inscrire Media Flyers Media Related Sectors Cosmetics Simply Predict Industrial Hygiene Haut de page

Ensure the safety of your cosmetic products with CEHTRA's expert Cosmetic Product Safety Report (CPSR) services. Our qualified toxicologists can assess the safety of your product and provide thorough guidance on the CPSR process. Contact us today for a consultation. CPSR If you're a cosmetics manufacturer looking to sell your products in the European Union, it's important to understand the requirements for a Cosmetic Product Safety Report (CPSR). A CPSR ensures that your product is safe for consumers and helps to protect public health. Contact a qualified person, such as a toxicologist, to help you prepare a CPSR and ensure that your product complies with the Cosmetics Regulation (EC) No 1223/2009. Don't risk fines or legal consequences - prioritize the safety of your customers with a thorough CPSR. Clarisse BAVOUX Head of Cosmetics clarisse.bavoux@cehtra.com Send us a message and we will answer you quickly. E-mail Company Your message Send Thank you for your submission! 1 \ What is a CPSR? A Cosmetic Product Safety Report (CPSR) is a document that presents the conclusion on the safety of a cosmetic product and the rationale used by the safety assessor. The report is required in the European Union under the Cosmetics Regulation (EC) No 1223/2009. The purpose of the CPSR is to consider the expected use, list the useful information, from literature or obtained on the product, and quantify any potential risk, if identified, to demonstrate that it can be used without any risk. 2 \ What does a CPSR include? A CPSR typically includes the following information: Part A: gathering information on the presentation of the product, its indications, its expected stability, compatibility with the pack, efficient preservation, information on traces, and tolerance results. Part B: presenting the conclusion, any warning if needed, the rationale to conclude on the different risks induced by the product, and the signature of the qualified safety assessor. An important part of the Safety Report is generally included in Annexes: the toxicological profiles, which must be provided for all ingredients. 3 \ Who prepares a CPSR? A CPSR must be prepared by a qualified person, a safety assessor, such as a toxicologist, who has the necessary diplomas and expertise to assess the safety of cosmetic products. The qualified person may be employed by the cosmetic product manufacturer or by a third-party company that specializes in safety assessments. At CEHTRA, several of our toxicologist can sign the CPSR. 4 \ Why is a CPSR important and what does CEHTRA recommends? A CPSR is important because it ensures that cosmetic products are safe for use by consumers. By identifying potential risks associated with the use of a cosmetic product, the CPSR helps to prevent harm to consumers and to protect public health. CEHTRA recommends a 1rst step before writing this report, in a pre-assessment, before starting any study. In addition, a CPSR is required by law in the European Union. Failure to comply with the requirements of the Cosmetics Regulation (EC) No 1223/2009 can result in fines and other legal consequences. Overall, the CPSR is a crucial component of ensuring the safety of cosmetic products on the market.

India’s Chemicals (Management And Safety) Rules (ICMSR) also referred to as ‘India REACH’ will come into force on the date of their publication in the Official Gazette, expected mid-2021. India’s Chemicals (Management And Safety) Rules India’s Chemicals (Management And Safety) Rules (ICMSR) also referred to as ‘India REACH’ will come into force on the date of their publication in the Official Gazette, expected mid-2021, and will regulate all substances, substances in mixtures, and intermediates that are manufactured, imported or placed on the market in the Indian territory at quantities greater than 1 tonne per year. Regulatory compliance requirements will apply within 18 months of coming into force, and all Indian manufacturers and importers will need to comply. Non-Indian entities who wish to place their chemical products on the market in India will need to appoint an authorised representative (AR) located in India to act on their behalf (similar to EU REACH OR). If your company is currently manufacturing chemicals in India or exporting chemicals to India, ICMSR will affect you. CEHTRA-India registered office in New Delhi is well positioned to act as your AR and service provider and can help you secure the Notification or Registration certificate for your chemicals from India’s Chemical Regulatory Division. The main requirements are: Notification and annual updating All existing and new substances manufactured or imported in India in quantities ≥ 1 tonne per year must be notified to The Chemical Regulatory Division (CRD). Existing substances should be notified within 180 days from the date of commencement of the Initial Notification Period (i.e. commences one year from the date of enforcement of ICMSR Rules). New substances must be notified at least 60 days prior to the date they are placed on the market in India. Notifiers shall update the information submitted annually, no later than 60 days after the end of each calendar year. Registration All priority substances listed in ICMSR Schedule II (currently 750) manufactured or imported (or intended or likely to be released from articles) in India in quantities ≥1 tonne per year will require the submission of a technical dossier within 18 months from the date of their inclusion in Schedule II. Substances manufactured or imported in India in quantities <1 tonne per year may also need to be registered; further details are yet to be published. Substances listed in Schedule II will be subject to authorization and restriction after further assessment. Safety Data Sheet (SDS) All Notifiers of a substance or an intermediate listed in Schedule II or a hazardous chemical will need to maintain and submit an up-to-date SDS in the UN-GHS format and will have to share such SDS with the Downstream User of the substance. Site Safety Report An occupier who has control of an industrial activity in which a hazardous chemical is handled is required to provide the evidence of identification and prevention of accidental hazards within 30 days of commencement of the activity or within 30 days of coming into force of these Rules, whichever is later. Depending on the threshold of quantities of hazardous chemicals, a site safety report or an independent safety audit report may also be required to be submitted within 90-180 days from the date of coming into force of these Rules. Import Notification After completion of notification or registration, importers of priority substances or hazardous chemicals must inform the concerned authority at least 15 days before the import of such substances in quantities greater than the lowest of 1 tonne, the quantity specified in column 3 of Schedule XII and column 3 of Schedule XI. Meet our expert Pramod KUMAR Regulatory Affairs Manager pramod.kumar@cehtra.com Key Services Notification / Registration & update Preparation and update of Notification and Registration dossiers for individual or joint submissions Safety Data Sheets (SDS) Preparation and/or update of SDS in latest UN-GHS format Authorized Representative (AR) service Representation of non-Indian companies through our Indian entity Data Management Arrangement of data on substances already registered with any foreign regulator in other jurisdictions Value-added Services PRIMO tool to optimize management and follow-up of complex worldwide registration projects Experienced data sharing negotiators Scientific and Regulatory expert advice GHS Classification of substances Related Tools Related Sectors Global Chemicals Notification

Welcome to CEHTRA's window to the worldwide regulatory support. Welcome to CEHTRA cker CEHTRA's window to worldwide regulatory support CEHTRAcker Map CEHTRAcker Interactive Map Select a country in the map below to see how CEHTRA can accompany you Locations in green indicate presence of CEHTRA offices Locations in blue indicate services available via CEHTRA's trusted partners Australia The Industrial Chemicals Act 2019, administered by AICIS, came into effect on 01 July 2020 and regulates the importation and manufacture of industrial chemicals in Australia. CEHTRA provides the following services: Categorization of introduction Definition of the scope of assessment (Listed / Exempted / Reported / Assessed) Scientific expertise Data Gap analysis, Testing strategy (incl. alternatives to in vivo testing), Scientific support Dossier preparation Submission and communication with authorities thought a local partner Go back to the interactive map CEHTRAcker Austalia CEHTRAcker Canada Canada Canada’s New Substances Notification (NSN) Regulations, under the Canadian Environmental Protection Act (CEPA), are a tiered system whereby specific data schedules are submitted based on annual volumes, imported or manufactured. The Canadian Authorities evaluate this information to determine if a substance presents an unreasonable risk to human health and/or the environment. Through our office located in Toronto, CEHTRA provides the following services: NSN Notification Strategies Canadian Agent Services NSN Dossier Preparation Communication with Authorities Notification schedule selection, Datagap analysis, Testing strategies (waivers, read-across, QSAR, laboratory testing), Scientific support Acting as authorized representative for clients without a business presence in Canada Compiling and submitting required administrative, hazard, and exposure information, Preparing waiver/read-across arguments Pre- and post- notification consultation with the Canadian Authorities, Confidential DSL Inventory status inquiries Go back to the interactive map China The revised Provisions on the Environmental Administration of New Chemical Substances (MEE Order No. 12) - effective from January 1, 2021 – regulates new chemical substance registration. Through our local partners, CEHTRA can assist you with the following services: Inventory IECSC search Notification R&D notification, Record notification, Simplified and Regular Registration Post-notification Obligations Representative service Annual Report, Certificate Renewal… Go back to the interactive map CEHTRAcker China Eurasia The Technical Regulation of Eurasian Economic Union (EAEU) on Safety of Chemical Products ТR.No.041/2017, known as Eurasia-REACH, approved on March 3rd 2017, deals with the Registration, Evaluation, Authorization, and Restriction of Chemical substances. Through our local partners, CEHTRA can assist you with EAEU dossiers. Inventory Notification Service Safety Data Sheets (SDS) Nominated representative service Late pre-nomination Preparation and/or update of SDS according to the GOST standards Representation of non-Eurasian companies Go back to the interactive map CEHTRAcker Eurasia European Union Through our offices in the EU, CEHTRA can assist you with the following services: Dossier compilation & update SIEF Management Only Representative Supply-chain management Lead registrant and co-registrant dossiers testing strategy Consortium and SIEF communication, administrative and financial management of LoA Representation of non-EU companies through our Only-Representative (OR) Legal Entity and UK-REACH Obligations as EU importer, manufacturer or Downstream-User (DU), notifications to ECHA Click here to be redirected to our page dedicated to EU REACH Go back to the interactive map CEHTRAcker EU India India’s Chemicals (Management And Safety) Rules (ICMSR) also referred to as ‘India REACH’ will come into force on the date of their publication in the Official Gazette, expected mid-2021, and will regulate all substances, substances in mixtures, and intermediates that are manufactured, imported or placed on the market in the Indian territory at quantities greater than 1 tonne per year. Through our office located in New Delhi, CEHTRA provides the following services: Notification/ Registration & update Safety Data Sheets (SDS) Authorized Representative (AR) service Data Management Preparation and update of Notification and Registration dossiers for individual or joint submissions Preparation and/or update of SDS in latest UN-GHS format Representation of non-Indian companies through our Indian entity Arrangement of data on substances already registered with any foreign regulator in other jurisdictions Click here to be redirected to our page dedicated to ICMSR Go back to the interactive map CEHTRAcker India Japan The Chemical Substances Control Law – referred to as CSCL – was firstly enacted in 1973 in Japan to prevent environmental pollution by chemical substances that pose a risk to human health or the environment. CSCL controls both new and existing substances. The Industrial Safety and Health Law – ISHL - was firstly enacted in 1972 to protect the safety and health of workers in workplaces in Japan. IHSL designates substances that are prohibited to manufacture or import, substances requiring permission and chemical substances requiring safety data sheets and labels. ISHL also controls new substances and requires manufacturers and importers to notify them to the Japanese Ministry of Labor and Welfare (MHLW) prior to production and importation. Through our local partners, CEHTRA can assist you with the following services: CSCL notification Standard (full) notification, Low volume notification (LVN), Small volume exemption (SVE), polymer… ISHL notification Standard notification, Low volume notification Safety Data Sheets (SDS) & Label Preparation and/or update of SDS / Label under Japanese standards Go back to the interactive map CEHTRAcker Japan New Zealand Pesticides, household chemicals and other dangerous goods and substances are regulated by the EPA (Environmental Protection Authority) under the Hazardous Substances and New Organisms Act 1996. All hazardous substances require approval in New Zealand prior to use. Depending on the substance and hazard classification, an approval may take the form of an Individual Approval or a Group Standard Approval. CEHTRA provides the following services: NZ GHS Assistance with the classification according to NZ GHS 7 Expertise Providing guidance on the most appropriate approval route Registration support Preparation of paperwork required for approval, including where necessary submission and communication with authorities. Go back to the interactive map CEHTRAcker New Zealand Philippines The Pre-Manufacturing and Pre-Importation Notification, known as PMPIN, aims to screen harmful substances before they enter the Philippine market. CEHTRA provides the following services: Dossier preparation Abbreviated or Detailed PMPIN Dossier submission Through a local partner (Abbreviated or Detailed PMPIN / SQI / PCL / CCO / Polymer) Go back to the interactive map CEHTRAcker Philippines South Korea The Act on Registration and Evaluation, etc. of Chemical Substances – referred to as “ARECs” or “K-REACH” - was implemented on January 1, 2015 by the Ministry of Environment (MOE) with the aim. of protecting public health and the environment by the registration of chemical substances. The Occupational Safety and Health Act - referred to as “OSHA” - is regulated by Ministry of Employment and Labor (MOEL), with the purpose of OSHA to maintain and promote the safety and health of workers by preventing industrial accidents and creating a comfortable working environment through establishing standards on occupational safety and health and clarifying where the responsibility lies. Through our local partners, CEHTRA can assist you with the following services: K-REACH registration KECL inventory search, registration dossiers, communication with MOE/NIER K-REACH OR Representation of non-Korean companies OSHA New Chemical MOEL’s inventory search, dossier preparation, communication with MOEL OSHA GHS GHS classification and preparation of GHS MSDS & Label Go back to the interactive map CEHTRAcker South Korea Taiwan Chemical regulation in Taiwan is covered by the EPA’s Regulation of New and Existing Chemical Substances Registration (Dec 11, 2014 - amended 2019) and the MOL’s Regulation of new chemical substances registration (Jan 1, 2015). Through our local partners, CEHTRA can assist you with the following services: Expertise Identification of regulatory obligations Registration Small Quantity, Simplified and Standard Registration CBI application Post-submission Obligations Annual Reporting Go back to the interactive map CEHTRAcker Taiwan Turkey The regulation Kimyasallarin Kaydi Degerlendirmesi Izni ve Kisitlamasi, known as KKDIK, published on 23rd June 2017 deals with the Registration, Evaluation, Authorization, and Restriction of Chemical substances. Through our local certified partners, CEHTRA can assist you with KKDIK dossiers. Dossier preparation Preparation of registration dossiers for individual or joint submissions SIEF management Safety Data Sheets (SDS) & Label Only representative service Consortium and SIEF communication, administrative and financial management Preparation and/or update of SDS / Label in Turkish language Representation of non-Turkish companies Go back to the interactive map CEHTRAcker Turkey CEHTRAcker UK United Kingdom The Brexit transition deadline of 31 December 2020 is fast approaching and it is vital that companies ensure that they remain compliant beyond this date. CEHTRA team remains available to answer any queries you may have to ensure you are compliant with the new regulatory framework which will apply from 1st January 2021. Through our offices located in the UK and the EU, CEHTRA can assist you with the following services: UK REACH Registration and OR UK REACH OR Consortium Management Click here to get redirected to our page dedicated to Brexit Go back to the interactive map CEHTRAcker USA USA The Lautenberg Chemical Safety Act (LCSA) was signed into law in 2016 to modernize the Toxic Substances Control Act (TSCA). New chemicals are still registered under the Premanufacture Notice (PMN) rules, but now the EPA conducts a risk-based review and must make an affirmative safety determination before they can be imported or manufactured. The LCSA empowers the EPA to request more up-front test data and information to characterize hazards, uses, releases, exposure scenarios, etc., meaning that more knowledge and effort is required to achieve a successful registration than ever. CEHTRA provides the following services: US PMN Strategies TSCA Inventory List status, Datagap analysis/Data quality check, CA chemical name and CAS RN assignment/proof assurance. LCSA Exemption Support PMN Submissions PMN Technical Contact Support Polymer Exemption qualification assessments, Low Volume Exemption applications, R&D/TME/LoREX support Compilation of PMN Form and supporting documentation in e-PMN/CDX, Sustainable Futures modelling Pre-Notice Consultation, Post- submission review support including consent orders and other EPA regulatory actions Go back to the interactive map

PRIMO stands for Principle Regulatory Information Management Organizer. PRIMO has been designed by our regulatory and IT experts to keep you up-to-date with regulatory compliance information for your projects. Already have a PRIMO account? Click here Unlock the power of Cloud Technology to manage your Worldwide Registrations … Introducing A CEHTRA-designed tool dedicated to your regulatory compliance What is PRIMO? PRIMO stands for Principle Regulatory Information Management Organizer . PRIMO has been designed by our regulatory and IT experts to keep you up-to-date with regulatory compliance information for your projects. A CEHTRA designed tool to allow: Sharing and secure storage of data Simultaneous access for client and CEHTRA Project management and planning Global regulatory data gap analysis to assist in designing testing strategies for all markets Project Management ✓ Allows members an overview of the status of their projects ✓ Track the progress of your projects (Gantt) ✓ Assign tasks and follow-up Working Documents ✓ Data Gap Analysis (DGA) ✓ Country-specific support for DGA based on country specific requirements ✓ Study Monitoring Dashboard Data Storage ✓ Secure sharing and storage of your data ✓ Easy upload and download of documents ✓ Exchange of large files Two licence options PRIMO Basic PRIMO Ultimate under development to best suit your needs Basic Ultimate Client Access* Upload/download documents Create/modify registration dossiers Create Tasks Track work progress (Gantt Chart) Access to country-specific DGA Access to country-specific support for DGA preparation Access to other clients' consultants Read-only ✓ Read/write ✓ ✓ ✓ Read-only Read-only ✓ Read/write Read/write ✓ ✓ * CEHTRA offers a free access to PRIMO Basic to all its clients. Media Flyers Access PRIMO Already have a PRIMO account? Click here to access Request a demo today! Drop your queries to: primo@cehtra.com or leave your messages on Let's Chat window below Acknowledgements Our project « Chèque transformation Numérique » has received a grant from the European Union under the FEDER-FSE Aquitaine 2014-2020 operational program.

CEHTRA ensures the safety and compliance of your cosmetic products via safety report (CPSR) and product information file (PIF). Our databases anticipate the risks of your products and give you access to numerous toxicological profiles. Our expertise extends to the eco-conceptions of your formula . Top of the page COSMETICS Cosmetick Contact Key Services CPSR Ecotoxicology Value-added Trainings Media Our Tools Check out if toxicological and eco-toxicological profiles for your ingredients of interest are covered in Cosmetick! Search profiles Tools Contact Key contacts Clarisse BAVOUX Head of Cosmetics clarisse.bavoux@cehtra.com Marlène BARON Toxicologist marlene.baron@cehtra.com Key Services Cosmetic products & formulations : safety, ecotoxicology, expert advice and regulatory reports Pre-assessment Cosmetic Product Safety Reports (CPSR) Ingredients, Raw Materials : Toxicity, Ecotoxicity and Maximum Doses Toxicological profiles Ecotoxicological profiles Identification of safe concentrations for cosmetic uses Ingredients under development: strategy, dossier (toxicology and ecotoxicology) Support for toxicological and ecotoxicological issues Testing strategy In silico approach Additional data Final dossier Literature search, bibliography In vitro tests: analysis and advice Management of da ta gaps by alternative methods (Read-Across, in silico approach) Key Services CEHTRA has been commissioned by numerous companies including multi-nationals in the cosmetics industry to assist them with cosmetic regulation compliance. CEHTRA evaluates the safety of several types of products (care, hygiene, perfumes...), and new ingredients. Cosmetick includes comprehensive databases allow us to anticipate risks for your products. We can propose complementary approaches in case of data gaps (structural alerts, QSAR, Read-across). Our eco-toxicologists can contribute to the eco-conceptions of your formula. At CEHTRA, we are professional partner of the Cosmetic Valley and provide different training courses on the Fundamentals of the Cosmetic Regulation, webinars on Content / Container Interactions or seminaire in University. "COSMETICK Advanced is a very useful tool for any cosmetic products safety assessor : all required data are gathered (very complete toxicological profils but also ecotoxicity data and regulation alerts). The tool can be used to assess the systemic risk of products ingredients and impurities. It also provides local tolerance alerts. It is very easy to use and a great help when you start working on a new project." Ecoxotoxicology Services and Tools in Ecotoxicology CEHTRA is committed to the protection of the environment, and offers services and tools in ecotoxicology: COSMETICK is an online software solution offering ecotoxicological profiles and an "Ecotoxicological Alerts" system for ingredients and formulas ECOSCORES can be customised to score and measure the ecotoxicological and environmental footprint of cosmetic products ECOTOXICOLOGICAL EVALUATIONS of ingredients and formulas allow prioritisation of ingredient choices up to the obtaining of Labels such as the EU ECOLABEL (rinsed and non-rinsed cosmetic products) MISSING DATA can be replaced in part by results from alternative methods (Read-Across, in silico approaches) Our ADVICE and REGULATORY support enable us to ensure the compliance of your products and ingredients, manage risks and anticipate regulatory changes. Value-added Services In-depth expertise for INCI, impurities and fragrance components, including MOS and QRA Hazard assessment (toxicology and ecotoxicology) Extensive and cross-cutting areas of expertise: from environment to human health, from formulation to packaging Data qualification Monitoring of studies Cosmetick database (toxicological & ecotoxicological profiles, formula analysis) Trainings 25 Mars 2025 Regulations in Europe and the USA for recycled plastics intended for contact with food and in cosmetics en savoir plus s'inscrire 10 Juin 2025 Introduction to packaging regulations: understanding and implementing them en savoir plus s'inscrire Media Flyers Value-added Services Trainings Media Related Sectors Packaging Simply Predict Our Partners Haut de page

CEHTRA ensures the compliance of your product dossiers and families of biocidal products (BPR) and active substances. Our expertise includes risk assessment, technical equivalence, biocidal consortiums as well as the evaluation of ED properties and substances of concern (SoCs). Top of the page Biocides Conformité Réglementaire et Évaluation des Risques Key Services CEHTRA's consultants has been involved in the preparation of several active substances Annex I inclusion dossiers and submission of biocidal products through the BPR process and under National schemes. Our team has also successfully completed many Biocide Product Registration and Biocide Products Family dossiers from start to finish without counting the numerous projects for regulatory support, Monitoring, Outdoor Operator Exposure Studies, Expert Advice and Position Papers. Biocidal Product Single Product Biocide Products Family EU R&D Notifications Active Substance New active substance Renewal of Active Substances approval Annex I inclusion Article 95 Listing Dossier Preparation Testing strategy Study Monitoring Alternatives to in vivo testing Consortia Management Testing strategy Study Monitoring Alternatives to in vivo testing Value-added Services Assessment of ED properties Negotiations with Authorities Risk Assessment and Modelling Technical Equivalence Data Sharing Negotiations Meet our experts Nathalie HANON Head of Biocides Mail Cyril DUROU Senior Ecotoxicologist Mail Annekathrin FAUPEL Senior Regulatory Manager Mail Training 18 Mars 2025 How do Biocidal Product Families work? Accelerate your time to market! en savoir plus s'inscrire 24 Mars 2025 Regulatory ecotoxicology: from the appropriate conduct of studies to environmental risk assessment en savoir plus s'inscrire Consortia QuAC (Biocides) Related Sectors Simply Predict Media Flyer Haut de page

I Understand the regulatory obligations of the different actors involved in authorising the marketing of a biocidal product How do Biocidal Product Families work? Accelerate your time to market! Discover How do Biocidal Product Families work? Accelerate your time to market! The basics > Ancre 1 Training > Overview Objectives I Skills and Abilities Understand the regulatory obligations of the different actors involved in authorising the marketing of a biocidal product Program Part 1 - Background to the Biocidal Products Regulation (BPR) Part 2 - Description of the different actors involved in the authorisation of Biocidal products Part 3 - Active substance Part 4 - Biocidal Products Part 5 - Assessment of learning through a final quiz Methodology used The training is delivered through a presentation containing case studies, role plays and continuous interaction with the expert. The support will be given to the trainees. A final quiz will validate the acquired knowledge. For better online learning, our training courses are held in small groups of a minimum of three people up to a maximum capacity of 6 people. Our courses are delivered through synchronous learning. Public Public Anyone concerned with the regulations of biocidal products. Prerequisites None. Chat Chat 7 hours Location Chat From 580€ Contact us Online French session Nathalie Hanon Head of Biocides Parole de client « I am very satisfied with this training course which is well adapted to my background and which met my needs. Furthermore, the distance learning format is entirely satisfactory, and the limited number of trainees facilitates exchanges. » La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. A propos de CEHTRA Nous sommes spécialisés depuis 20 ans dans l’accompagnement des entreprises pour la mise sur le marché de substances ou produits chimiques en France et également en Europe, et hors Europe. Nos toxicologues, écotoxicologues, chimistes mettent à votre disposition leur expertise pour assurer la conformité réglementaire de vos produits. Avec une équipe de 70 personnes, nous couvrons une dizaine de secteurs dont REACH, les biocides, les produits phytosanitaires… +

I Areas: food contact, cosmetics and pharmaceuticals Understand the regulatory prerequisites for cosmetic, food contact and pharmaceutical packaging Acquire an overview of the regulatory texts applicable to materials Be familiar with the essential requirements and specific features of this legislation Understand a container/content risk assessment (LMS) Introduction to packaging regulations: understanding and implementing them En savoir plus Training > Introduction to packaging regulations: understanding and implementing them The basics > Ancre 1 Overview 10.06.25 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? 16.09.25 Register Objectives I Skills and Abilities Areas: food contact, cosmetics and pharmaceuticals Understand the regulatory prerequisites for cosmetic, food contact and pharmaceutical packaging Acquire an overview of the regulatory texts applicable to materials Be familiar with the essential requirements and specific features of this legislation Understand a container/content risk assessment (LMS) Program Part 1 - Regulatory requirements for cosmetic packaging Part 2 - Regulatory requirements for food contact packaging Part 3 - Migration principles (container-content interactions) Part 4 - Regulatory requirements for pharmaceutical packaging Part 5 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience Regulatory, Technical and Quality positions. Prerequisites None. Request for information Download the catalogue. Download Trainer Caroline Optiz Head of Packaging About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Understand the obligations under REACH and the impact/penalties in the event of non-compliance Know how to draw up an extended safety data sheet As a downstream user, know how to check your own compliance with supplier SDSs Be familiar with the methods for ensuring compliance in the event of discrepancies between downstream uses and the exposure scenarios covered by the eSDS Familiarise yourself with eSDS: obligations, content and compliance En savoir plus Training > Familiarise yourself with eSDS: obligations, content and compliance The basics > Ancre 1 Overview 29.04.25 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? 21.10.25 Register Objectives I Skills and Abilities Understand the obligations under REACH and the impact/penalties in the event of non-compliance Know how to draw up an extended safety data sheet As a downstream user, know how to check your own compliance with supplier SDSs Be familiar with the methods for ensuring compliance in the event of discrepancies between downstream uses and the exposure scenarios covered by the eSDS Program Part 1 - Actors in the supply chain Part 2 - Obligation of eSDS producers under REACH Part 3 - Key stages in the construction of the CSA/CSR Part 4 - Construction of an extended safety data sheet Part 5 - Stages on receipt of a supplier SDS: compliance objective Part 6 - Impacts/sanctions in the event of non-compliance Part 7 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience People working under the REACH Regulation: - QHSE - manufacturers, formulators, chemical product manufacturers Prerequisites Notions on REACH regulations. Notions on SDS (sections 1-16). Request for information Download the catalogue. Download Trainer Anna Chelle Expologist and regulatory toxicologist About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Addressing the stages of an application for authorisation of a family of biocidal products : - Similarity of composition & grouping of co-formulants - Similarity of uses - Similar level of risk and efficacy Addressing the various points to be taken into account when dividing biocidal product families for current evaluations How do Biocidal Product Families work? Accelerate your time to market! En savoir plus Training > How do Biocidal Product Families work? Accelerate your time to market! The basics > Ancre 1 Overview 18.03.25 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities Addressing the stages of an application for authorisation of a family of biocidal products : - Similarity of composition & grouping of co-formulants - Similarity of uses - Similar level of risk and efficacy Addressing the various points to be taken into account when dividing biocidal product families for current evaluations Program Partie 1 - Evaluation de la similarité - Assessment of similarity : - Similarité de la composition et regroupement des coformulants - Similarité des utilisations - Similitude du niveau de risque et d'efficacité Partie 2 - Division des familles de produits biocides pour les évaluations en cours - Splitting of families for on-going applications Partie 3 - 'Best practices' pour les reunions de pré-soumission - Best practices for pre-submission meeting Partie 4 - Evaluation des acquis au travers d'un quizz final Methods used The course is based on a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience Anyone concerned by the regulations governing biocidal products. Prerequisites Review the GMP guide before the training course (CA-July19-Doc.4.2-Final -Guidance note on GMP concept_rev2). Request for information Download the catalogue. Download Trainer Nathalie Hanon Head of Biocides About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Understand the place of toxicology in the life of substances according to the regulations Knowing the main tests, their difficulties, their stakes Optimise the interaction between managers and experts Toxicology and Classification - the fundamentals of your regulatory success Discover Toxicology and Classification - the fundamentals of your regulatory success The basics > Ancre 1 Training > Overview Objectives I Skills and Abilities Understand the place of toxicology in the life of substances according to the regulations Knowing the main tests, their difficulties, their stakes Optimise the interaction between managers and experts Program Part 1 - Regulatory Toxicology ? General Part 2 - ADME (Absorption, Distribution, Metabolism, Excretion): concepts Part 3 - Acute systemic toxicology (oral, dermal, inhalation) Part 4 - Local skin and eye tolerance Part 5 - Skin Sensitisation Part 6 - Repeat and Chronic Toxicity Part 7 - Reproductive and Developmental Toxicity Part 8 - Mutagenicity and Genotoxicity - Classification Part 9 - Carcinogenesis Part 10 - Introduction to alternative non-experimental methods used in toxicology Part 11 - Introduction to the determination of Toxicological Reference Values Part 12 - Introduction to Human Health Risk Assessment Part 13 - Toxicology described through a regulatory dossier (REACH) - case study Part 14 - Assessment of learning through a final quiz Methodology used The training is delivered through a presentation containing case studies, role plays and continuous interaction with the expert. The support will be given to the trainees. A final quiz will validate the acquired knowledge. For better online learning, our training courses are held in small groups of a minimum of three people up to a maximum capacity of 6 people. Our courses are delivered through synchronous learning. Public Public Employees involved in product safety. Prerequisites None. Chat Chat 14 hours Location Chat From 1160€ Contact us Online French session Nathalie Mayer Toxicologist Parole de client « I am very satisfied with this training course which is well adapted to my background and which met my needs. Furthermore, the distance learning format is entirely satisfactory, and the limited number of trainees facilitates exchanges. » La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. A propos de CEHTRA Nous sommes spécialisés depuis 20 ans dans l’accompagnement des entreprises pour la mise sur le marché de substances ou produits chimiques en France et également en Europe, et hors Europe. Nos toxicologues, écotoxicologues, chimistes mettent à votre disposition leur expertise pour assurer la conformité réglementaire de vos produits. Avec une équipe de 70 personnes, nous couvrons une dizaine de secteurs dont REACH, les biocides, les produits phytosanitaires… +

I Understand the obligations under REACH How to use CHESAR to carry out a CSA (Chemical Safety Assessment) Be able to generate a CSR (Chemical Safety Report) under CHESAR Comply with ECHA expectations Master CHESAR to simplify your REACH assessments En savoir plus Training > Master CHESAR to simplify your REACH assessments The basics > Ancre 1 Overview 02.04.25 to 03.04.25 10h30 hours Online French from 1035€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? 07.10.2025 to 08.10.25 Register Objectives I Skills and Abilities Understand the obligations under REACH How to use CHESAR to carry out a CSA (Chemical Safety Assessment) Be able to generate a CSR (Chemical Safety Report) under CHESAR Comply with ECHA expectations Program Part 1 - Obligations under REACH with regard to CSR Part 2 - Definition and construction stages of the CSA Part 3 - Occupational risk assessment Part 4 - Consumer risk assessment Part 5 - Environmental risk assessment Part 6 - Creation of the complete CSR and compliance with ECHA controls Part 7 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience People working on REACH regulations: - Regulatory affairs officer - Toxicologist - Ecotoxicologist - QHSE Prerequisites Notions on REACH regulations. Request for information Download the catalogue. Download Trainer Anna Chelle Expologist and regulatory toxicologist About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I How to navigate and enter data in IUCLID Be familiar with the main non-technical sections of a REACH dossier and know how to complete them Be able to proofread the technical sections of a REACH dossier Know how to use the various features of IUCLID (exports, validation wizards) Be able to submit a dossier in REACH IT Master IUCLID and register your substances under REACH En savoir plus Training > Master IUCLID and register your substances under REACH The basics > Ancre 1 Overview 06.03.25 3h30 Online French from 345€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities How to navigate and enter data in IUCLID Be familiar with the main non-technical sections of a REACH dossier and know how to complete them Be able to proofread the technical sections of a REACH dossier Know how to use the various features of IUCLID (exports, validation wizards) Be able to submit a dossier in REACH IT Program Part 1 - Introduction to IUCLID 6 Part 2 - Preparing an IUCLID file: company-specific sections, technical sections, Chesar-IUCLID interaction Part 3 - Validation Wizard and plug-ins? IUCLID Part 4 - Dossier creation and submission on REACH IT Part 5 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience Any user of IUCLID 6 to prepare and/or submit REACH dossiers. Prerequisites Access to IUCLID. Be familiar with the REACH regulation and its requirements. Request for information Download the catalogue. Download Trainer Nathalie Mayer Toxicologist About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Understand the role of toxicology in the life of substances in accordance with regulations Understanding the main tests, their difficulties and the issues involved Optimising interaction between managers and experts Toxicology and Classification - the fundamentals of your regulatory success En savoir plus Training > Toxicology and Classification - the fundamentals of your regulatory success The basics > Ancre 1 Overview 12.06.25 to 13.06.25 14 hours Online French from 1380€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities Understand the role of toxicology in the life of substances in accordance with regulations Understanding the main tests, their difficulties and the issues involved Optimising interaction between managers and experts Program Part 1 - Regulatory toxicology ? General information Part 2 - ADME (Absorption, Distribution, Metabolism, Excretion): concepts Part 3 - Acute systemic toxicology (oral, cutaneous, inhalation) Part 4 - Local skin and eye tolerance Part 5 - Skin sensitisation Part 6 - Repeated-dose and chronic toxicity Part 7 - Reproductive and developmental toxicity Part 8 - Mutagenicity and genotoxicity - Classification Part 9 - Carcinogenesis Part 10 - Introduction to non-experimental alternative methods used in toxicology Part 11 - Introduction to the determination of Toxicological Reference Values Part 12 - Introduction to human health risk assessment Part 13 - Assessment of knowledge through a final quiz Methods used The course is based around an interactive presentation with ongoing engagement between the trainees and the expert. Trainees will be provided with the course materials. A final quiz will validate the knowledge acquired. To enhance e-learning, our courses are run in small groups, ranging from a minimum of three people to a maximum of six. Our courses are delivered through synchronous learning. Public Audience Employees involved in product safety. Prerequisites None. Request for information Download the catalogue. Download Trainer Nathalie Mayer Toxicologist 2024 « Formation très complète, très claire et très utile. Formatrices très professionnelles. » About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Know and understand the Cosmetic Regulation n°1223/2009 Understand the risk assessment of a cosmetic product Identify the points of improvement to comply with regulatory obligations Safer cosmetics for tomorrow - Know your regulatory obligations Discover Safer cosmetics for tomorrow - Know your regulatory obligations The basics > Ancre 1 Training > Overview Objectives I Skills and Abilities Know and understand the Cosmetic Regulation n°1223/2009 Understand the risk assessment of a cosmetic product Identify the points of improvement to comply with regulatory obligations Program Part 1 - Regulatory context of cosmetic products (Europe and other countries) European Cosmetic Regulation n° 1223/2009 - Scope of application / Borderline products - Cosmetovigilance - Management of updates Part 2 - Cosmetic Product Safety Report Cosmetic product safety report - Concept of safety assessment: MoS calculation, local tolerance... - Toxicological profiles on ingredients Part 3 - Specific cases - Baby products, perfumes - In silico Part 4 - Q&A I Assessment of knowledge through a final quiz Methodology used The training is delivered through a presentation containing case studies, role plays and continuous interaction with the expert. The support will be given to the trainees. A final quiz will validate the acquired knowledge. For better online learning, our training courses are held in small groups of a minimum of three people up to a maximum capacity of 6 people. Our courses are delivered through synchronous learning. Public Public R&D, Regulatory, Quality, Safety assessor, Manufacturers, Distributors, Subcontractors, Suppliers, Importers. Prerequisites Cosmetic regulatory officer or toxicologist. Chat Chat 7 hours Location Chat From 580€ Contact us Online French session Clarisse Bavoux Head of Cosmetics Parole de client « I am very satisfied with this training course which is well adapted to my background and which met my needs. Clarisse Bavoux is very clear in her explanations, the presentation is well structured and the references are provided, which is very useful to work on after the training. » La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. A propos de CEHTRA Nous sommes spécialisés depuis 20 ans dans l’accompagnement des entreprises pour la mise sur le marché de substances ou produits chimiques en France et également en Europe, et hors Europe. Nos toxicologues, écotoxicologues, chimistes mettent à votre disposition leur expertise pour assurer la conformité réglementaire de vos produits. Avec une équipe de 70 personnes, nous couvrons une dizaine de secteurs dont REACH, les biocides, les produits phytosanitaires… +

I Better understand why studies are carried out, what the results mean and how they can be used for Classification & Labelling and Risk Assessment Be able to spot study pitfalls and know how to avoid them Regulatory Ecotoxicology: From appropriate study conduct to environmental risk assessment Discover Regulatory Ecotoxicology: From appropriate study conduct to environmental risk assessment The basics > Ancre 1 Training > Overview Objectives I Skills and Abilities Better understand why studies are carried out, what the results mean and how they can be used for Classification & Labelling and Risk Assessment Be able to spot study pitfalls and know how to avoid them Program Part 1 - Environmental data Reminder of useful physico-chemical parameters Abiotic degradation studies Biotic degradation studies Part 2 - Ecotoxicology Organisms used in regulatory ecotoxicology Ecotoxicology studies: methods Principle of the studies: critical parameters Alternative non-experimental methods used in ecotoxicology Part 3 - Regulatory use of data PBT, POP assessment Risk assessment: Principle and derivation of PNEC from ecotoxicology studies Classification SDS Part 4 - Q&A I Evaluation of knowledge through a final quiz Methodology used The training is delivered through a presentation containing case studies, role plays and continuous interaction with the expert. The support will be given to the trainees. A final quiz will validate the acquired knowledge. For better online learning, our training courses are held in small groups of a minimum of three people up to a maximum capacity of 6 people. Our courses are delivered through synchronous learning. Public Public Scientists and Regulatory Affairs Officers. Prerequisites Bac +2. Chat Chat 10.5 Hours Location Chat From 870€ Contact us Online French session Blandine Journel Expert Ecotoxicologist Parole de client « The training was very comprehensive and understandable, including concrete cases to illustrate the concepts discussed. I now have a global vision of the existing ecotoxicological tests and have more insight on the type of tests to be conducted according to the ingredient to be tested. » La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. A propos de CEHTRA Nous sommes spécialisés depuis 20 ans dans l’accompagnement des entreprises pour la mise sur le marché de substances ou produits chimiques en France et également en Europe, et hors Europe. Nos toxicologues, écotoxicologues, chimistes mettent à votre disposition leur expertise pour assurer la conformité réglementaire de vos produits. Avec une équipe de 70 personnes, nous couvrons une dizaine de secteurs dont REACH, les biocides, les produits phytosanitaires… +

I Understanding regulatory procedures for active substances and products Understanding zonal assessment and dRR dossiers Understanding the content of dossiers and the pitfalls to avoid Plant Protection Products: from regulation to registration En savoir plus Training > Plant Protection Products: from regulation to registration The basics > Ancre 1 Overview 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities Understanding regulatory procedures for active substances and products Understanding zonal assessment and dRR dossiers Understanding the content of dossiers and the pitfalls to avoid Program Part 1 - Regulation (EC) No 1107/2009 The main points The different procedures involved Part 2 - Zonal assessment Zonal assessment: North, Centre and South zones: similarities and differences Exchanges between the Notifier and the Competent Authorities Part 3 - Requirements - The Dossier New requirements: for which substances? for which products? Bringing an existing dossier into line with the new regulatory requirements Part 4 - Case studies Part 5 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience Regulatory Affairs Officer in charge of Products/Active Substances. Prerequisites Scientific background. Beginner in regulatory affairs for plant protection products. Request for information Download the catalogue. Download Trainer Estelle Beltran Head of Plant Protection Products About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Gain a better understanding of why studies are carried out, what the results mean and how they can be used for Classification and Risk Assessment. Be able to spot the pitfalls of studies and know how to avoid them Regulatory ecotoxicology: from the appropriate conduct of studies to environmental risk assessment En savoir plus Training > Regulatory ecotoxicology: from the appropriate conduct of studies to environmental risk assessment The basics > Ancre 1 Overview 24.03.25 to 25.03.25 10h30 Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? 06.10.25 to 07.10.25 Register Objectives I Skills and Abilities Gain a better understanding of why studies are carried out, what the results mean and how they can be used for Classification and Risk Assessment. Be able to spot the pitfalls of studies and know how to avoid them Program Part 1 – Environmental data Review of useful physico-chemical parameters Study of abiotic degradation Study of biotic degradation Bioaccumulation Part 2 – Ecotoxicity Organisms used in regulatory ecotoxicology Ecotoxicity studies: methods Study principles: critical parameters Non-experimental alternative methods used in ecotoxicology Part 3 – Regulatory use of data PBT, POP, PMT evaluation Risk assessment: Principle and Derivation of PNECs from ecotoxicity studies Classification SDS (Safety Data Sheets) Part 4 – Q&A | Knowledge assessment through a final quiz Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. English-language support material will be provided to trainees. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience Scientists and Regulatory Affairs Managers. Prerequisites Bac +2. Request for information Download the catalogue. Download Trainer Blandine Journel Senior Ecotoxicologist About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Understand the regulatory procedures for active substances and for products Understand zonal evaluation and dRR dossiers Understand the content of the dossiers and the pitfalls to avoid Plant Protection Products: from regulation to registration Discover Plant Protection Products: from regulation to registration The basics > Ancre 1 Training > Overview Objectives I Skills and Abilities Understand the regulatory procedures for active substances and for products Understand zonal evaluation and dRR dossiers Understand the content of the dossiers and the pitfalls to avoid Program Part 1 - Regulation (EC) No 1107/2009 The main points The different procedures involved Part 2 - Zonal assessment Zonal evaluation: North, Central and South zones: similarities and differences Exchanges between the Notifier and the Competent Authorities Part 3 - The Requirements - The Dossier New requirements: for which substances? for which products? Bringing an existing dossier into line with the new regulatory obligations Part 4 - Case studies Part 5 - Q&A I Assessment of acquired skills through a final quiz Methodology used The training is delivered through a presentation containing case studies, role plays and continuous interaction with the expert. The support will be given to the trainees. A final quiz will validate the acquired knowledge. For better online learning, our training courses are held in small groups of a minimum of three people up to a maximum capacity of 6 people. Our courses are delivered through synchronous learning. Public Public Regulatory Affairs Officer responsible for products/active substances. Prerequisites Scientific background. Beginner in regulatory affairs for plant protection products. Chat Chat 7 Hours Location Chat From 580€ Contact us Online French session Estelle Beltran Head of Plant Protection Parole de client « I will recommend it to my close colleagues. » La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. A propos de CEHTRA Nous sommes spécialisés depuis 20 ans dans l’accompagnement des entreprises pour la mise sur le marché de substances ou produits chimiques en France et également en Europe, et hors Europe. Nos toxicologues, écotoxicologues, chimistes mettent à votre disposition leur expertise pour assurer la conformité réglementaire de vos produits. Avec une équipe de 70 personnes, nous couvrons une dizaine de secteurs dont REACH, les biocides, les produits phytosanitaires… +

I Addressing the stages of an application for authorisation of a family of biocidal products : Similarity of composition & grouping of co-formulants Similarity of uses Similar level of risk and efficacy Addressing the various points to be taken into account when dividing biocidal product families for current evaluations. Familiarise yourself with SDSe: obligations, content and compliance Discover Familiarise yourself with SDSe: obligations, content and compliance The basics > Ancre 1 Training > Overview Objectives I Skills and Abilities Addressing the stages of an application for authorisation of a family of biocidal products : Similarity of composition & grouping of co-formulants Similarity of uses Similar level of risk and efficacy Addressing the various points to be taken into account when dividing biocidal product families for current evaluations. Program Part 1 - Actors in the supply chain Part 2 - Obligation under REACH for eSDS producers Part 3 - Main steps in the construction of the CSA/CSR Part 4 - Construction of an extended safety data sheet Part 5 - Steps when receiving a supplier SDS: compliance objective Part 6 - Impacts/sanctions in case of non-compliance Part 7 - Q&A I Assessment of skills acquired through a final quiz Methodology used The training is delivered through a presentation containing case studies, role plays and continuous interaction with the expert. The support will be given to the trainees. A final quiz will validate the acquired knowledge. For better online learning, our training courses are held in small groups of a minimum of three people up to a maximum capacity of 6 people. Our courses are delivered through synchronous learning. Public Public People working under the REACH Regulation: - QHSE - manufacturers, formulators, chemical manufacturers Prerequisites Knowledge of the REACH Regulation. Knowledge of SDS (sections 1-16). Chat Chat 7 Hours Location Chat From 580€ Contact us Online French session Anna Chelle Expologist and regulatory toxicologist Parole de client « I am very satisfied with this course, which was well adapted to my background and met my needs. Furthermore, the distance learning format is entirely satisfactory, and the limited number of trainees facilitates exchanges. » La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. A propos de CEHTRA Nous sommes spécialisés depuis 20 ans dans l’accompagnement des entreprises pour la mise sur le marché de substances ou produits chimiques en France et également en Europe, et hors Europe. Nos toxicologues, écotoxicologues, chimistes mettent à votre disposition leur expertise pour assurer la conformité réglementaire de vos produits. Avec une équipe de 70 personnes, nous couvrons une dizaine de secteurs dont REACH, les biocides, les produits phytosanitaires… +

I Be able to describe the basics of European regulation 2022/1616/EC for recycled plastics in contact with foodstuffs Be able to describe the basics of US regulations for recycled plastics: No Objection Letters, processes, etc. Regulations in Europe and the USA for recycled plastics intended for contact with food and in cosmetics En savoir plus Training > Regulations in Europe and the USA for recycled plastics intended for contact with food and in cosmetics The basics > Ancre 1 Overview 25.03.25 1h30 Online French from 148€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? 17.06.25 Register Objectives I Skills and Abilities Be able to describe the basics of European regulation 2022/1616/EC for recycled plastics in contact with foodstuffs Be able to describe the basics of US regulations for recycled plastics: No Objection Letters, processes, etc. Program Part 1 - Regulation 2022/1616/EC - Recycled plastic articles Part 2 - FDA - No Objection Letter (NOL) - recycled plastic articles Part 3 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based on a presentation with role-playing exercises and ongoing interaction with the expert. The support material will be given to the trainees. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 8. Our courses are delivered through synchronous learning. Public Audience Players in the food and cosmetics packaging industry. Prerequisites None. Request for information Download the catalogue. Download Trainer Caroline Optiz Head of Packaging About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Know the obligations under REACH Know how to use CHESAR to perform a CSA (Chemical Safety Assessment) Know how to generate a CSR (Chemical Safety Report) under CHESAR To be in compliance with ECHA expectations Master CHESAR to simplify your REACH evaluations Discover Master CHESAR to simplify your REACH evaluations The basics > Ancre 1 Training > Overview Objectives I Skills and Abilities Know the obligations under REACH Know how to use CHESAR to perform a CSA (Chemical Safety Assessment) Know how to generate a CSR (Chemical Safety Report) under CHESAR To be in compliance with ECHA expectations Program Part 1 - Obligation under REACH towards CSR Part 2 - Definition and construction steps of the CSA Part 3 - Occupational risk assessment Part 4 - Consumer risk assessment Part 5 - Environmental risk assessment Part 6 - Creation of the full CSR and compliance with ECHA controls Part 7 - Q&A I Assessment of competence acquisition through a final quiz Methodology used The training is delivered through a presentation containing case studies, role plays and continuous interaction with the expert. The support will be given to the trainees. A final quiz will validate the acquired knowledge. For better online learning, our training courses are held in small groups of a minimum of three people up to a maximum capacity of 6 people. Our courses are delivered through synchronous learning. Public Public People working in the framework of the REACH Regulation: - Regulatory Affairs Officer - Toxicologist - Ecotoxicologist - QHSE Prerequisites Notions on the REACH Regulation. Chat Chat 7 Hours Location Chat From 580€ Contact us Online French session Anna Chelle Expologist and regulatory toxicologist Parole de client « Very good. Very useful information. I will use the slides in my daily work. Anna was very clear and answered our questions. She also adapted to our needs and focused on the most relevant points for us. Many thanks. » La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. A propos de CEHTRA Nous sommes spécialisés depuis 20 ans dans l’accompagnement des entreprises pour la mise sur le marché de substances ou produits chimiques en France et également en Europe, et hors Europe. Nos toxicologues, écotoxicologues, chimistes mettent à votre disposition leur expertise pour assurer la conformité réglementaire de vos produits. Avec une équipe de 70 personnes, nous couvrons une dizaine de secteurs dont REACH, les biocides, les produits phytosanitaires… +

I Knowing and understanding Cosmetics Regulation 1223/2009 Understand the risk assessment of a cosmetic product Identify areas for improvement in order to comply with regulatory obligations Safer cosmetics for tomorrow - Know your regulatory obligations En savoir plus Training > Safer cosmetics for tomorrow - Know your regulatory obligations The basics > Ancre 1 Overview Coming soon 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities Knowing and understanding Cosmetics Regulation 1223/2009 Understand the risk assessment of a cosmetic product Identify areas for improvement in order to comply with regulatory obligations Program Part 1 - Regulatory context for cosmetic products (Europe and other countries) European Cosmetics Regulation n° 1223/2009 - Scope / Borderline products - Cosmetovigilance - Management of updates Part 2 - Cosmetic product safety report - Notion of safety assessment: MoS calculation, local tolerance, etc. - Toxicological profiles of ingredients Part 3 - Specific cases - Baby products, perfumes - In silico Part 4 - Q&A I Assessment of knowledge acquired through a final quiz Methods used The course is based on a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience R&D, Regulatory, Quality, Safety Assessors, Manufacturers, Distributors, Subcontractors, Suppliers, Importers. Prerequisites Cosmetics regulatory affairs officer or toxicologist. Request for information Download the catalogue. Download Trainer Clarisse Bavoux Head of Cosmetics About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Understand the methodology for the toxicological assessment of medical device components in accordance with ISO 10993-17:2023. New ISO 10993-17 : 2023 - General and new features En savoir plus Training > New ISO 10993-17 : 2023 - General and new features The basics > Ancre 1 Overview 29.09.25 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities Understand the methodology for the toxicological assessment of medical device components in accordance with ISO 10993-17:2023. Program ISO 10993-17, BACKGROUND AND CONTEXT OF THE UPDATE Part 1 - Introduction Scope (releasables, raw materials, degradation products, risks covered) Links with other ISO 10993 standards (-1, -18, -9 etc.) - When is it useful and/or essential? ISO 10993-17 (2002) VS ISO 10993-17 (2023) : A NEW APPROACH Part 2 - What's new New terms, definitions and concepts New approaches: taking into account time periods; adapting exposure by weight (previously tolerable intake by weight). Part 3 - Data generation Characterisation according to ISO 10993-18 - Reminder and pre-test considerations AET - (Analytical Evaluation Treshold) - Importance of validating the method Types of data sought for the TRA. Part 4 - Toxicological Risk Assessment Toxicological Screening Limit (TSL) Exposure (EEDmax) Tolerable intake or contact (TI, TIcancer, TCL) Calculation of MOS Part 5 - Conclusion: Endpoint to be assessed Part 6 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based around a presentation containing case studies and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience DM players responsible for toxicological risk analysis and biocompatibility assessment, quality managers, functions responsible for compiling technical documentation. Prerequisites General knowledge of issues relating to the biocompatibility of healthcare products, in particular ISO standards 10993-18, -12 and -1. As this is not initial training, knowledge of the previous version of ISO 10993-17: 2002 and basic toxicology concepts is very important (threshold value, exposure dose, systemic vs. local toxicity, NOAEL/LOAEL, etc.). Request for information Download the catalogue. Download Trainer Paul Fernandes Biocompatibility toxicologist About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Understand the methodology of biological assessment in accordance with EN ISO 10993-1 Assess the conformity of a biological assessment plan Biological evaluation of medical devices in accordance with EN ISO 10993-1 En savoir plus Training > Biological evaluation of medical devices in accordance with EN ISO 10993-1 The basics > Ancre 1 Overview 31.03.25 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? 22.09.25 Register Objectives I Skills and Abilities Understand the methodology of biological assessment in accordance with EN ISO 10993-1 Assess the conformity of a biological assessment plan Program Part 1 - Context of the standard in European regulations Part 2 - The fundamental principles of the ISO 10993 series Part 3 - Biological assessment using the methodology of EN ISO 10993-1 Part 4 - Case study to conclude on the conformity of the proposed biological assessment plan Part 5 - Evaluation by questionnaire Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will receive a handout. A final quiz will validate what has been learnt. To enhance online learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience DM players. Quality managers. Functions responsible for compiling technical documentation. Prerequisites Knowledge of medical device risk classes, the EU certification process as presented in Regulation 2017/745. General knowledge of issues relating to the biocompatibility of healthcare products. Request for information Download the catalogue. Download Trainer Paul Fernandes Biocompatibility toxicologist About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +