CEHTRAWATCH is a regulatory and toxicological monitoring platform for chemical substances. Stay ahead of CLP, SVHC, and global regulatory changes with automated, centralized monitoring. CEHTRAWATCH: regulatory & toxicological platform focused on your substances Designed by scientific and regulatory experts at CEHTRA, CEHTRAWATCH transforms regulatory monitoring into an automated, structured, and actionable system. Discover Book a demo Anticipate regulatory changes before they impact your substances Traditional regulatory monitoring is fragmented, manual, and time-consuming. CEHTRAWATCH replaces this complexity with a unified, automated system that continuously tracks global regulatory and toxicological sources. By focusing only on the substances that matter to your organization, the platform transforms raw regulatory data into clear, actionable intelligence for regulatory affairs, toxicology, R&D, and product stewardship teams. Book a demo Regulatory Monitoring Challenges and the Benefits of a Regulatory Intelligence Platform. Missed updates → compliance risk increases Traditional regulatory monitoring Manual tracking leads to delayed identification of regulatory changes, increasing the risk of non-compliance, reformulation delays, and uncertainty. CEHTRAWATCH Continuous automated monitoring ensures real-time detection of relevant regulatory and toxicological updates, reducing compliance risk and eliminating manual gaps. High operational costs → inefficient use of expert time Traditional regulatory monitoring Regulatory teams spend significant time on repetitive manual screening instead of focusing on strategic regulatory analysis and decision-making. CEHTRAWATCH Automation reduces monitoring time from hours to minutes, enabling teams to focus on higher-value regulatory intelligence and expertise. Limited anticipation → reactive compliance Traditional regulatory monitoring Without structured early signals, organizations often react too late to upcoming regulatory changes. CEHTRAWATCH Integrated regulatory intent tracking and early signals enable proactive anticipation of upcoming changes before implementation. Fragmented information → lack of global visibility Traditional regulatory monitoring Regulatory data is scattered across jurisdictions, internal teams, and multiple external sources, making consolidation difficult. CEHTRAWATCH A unified platform centralizes global regulatory and toxicological information into a single structured view. Unstructured collection → low operational usability Traditional regulatory monitoring Information is collected inconsistently, making it difficult to standardize, analyze, or integrate into workflows. CEHTRAWATCH Structured data transforms raw regulatory inputs into standardized, exportable insights (Excel-ready and integration-friendly). Information overload → low signal-to-noise ratio Traditional regulatory monitoring Teams are overwhelmed by irrelevant updates that do not concern their substance portfolio. CEHTRAWATCH Targeted alerts filter out noise and deliver only relevant updates tailored to your specific substance portfolio. How CEHTRAWATCH Works: Real-Time Chemical Regulatory Monitoring and Alerts 1. Upload your substance portfolio Import your substance list into the platform. 2. Automated analysis The system continuously cross-references your substances with global regulatory and toxicological updates. 3. Continuous monitoring Relevant changes are detected and filtered automatically. 4. Actionable alerts Receive only the insights that matter for regulatory decision-making. Book a demo Need help? Here are the answers to your questions. How does CEHTRAWATCH save time compared to manual regulatory monitoring? CEHTRAWATCH enables targeted regulatory and toxicological monitoring based on your substance portfolio. After importing your substance list, the platform automatically tracks their presence across multiple regulatory and toxicological lists. Relevant updates are identified and displayed in your dashboard or via alerts. Regulatory and toxicology teams no longer need to manually search multiple sources and can focus on impact analysis for their products and activities. How does CEHTRAWATCH help reduce compliance risks? Regulatory and toxicological changes can directly impact the use of substances. CEHTRAWATCH allows you to quickly identify whether a substance in your portfolio appears or evolves in a regulatory or toxicological list. Updates are integrated into the platform and changes between versions are highlighted. This targeted monitoring helps teams detect early changes that may affect compliance or risk assessment. Which regulatory and toxicological lists are monitored? CEHTRAWATCH monitors a wide range of regulatory and toxicological lists relevant to the chemical industry, including: European regulations (CLP, REACH, Cosmetics Regulation) SVHC and CLH intentions key national lists toxicological monographs (IARC, NTP…) toxicological reference values All updates are filtered based on your substance portfolio to ensure relevance. Does CEHTRAWATCH replace regulatory or toxicological expertise? No. CEHTRAWATCH does not replace human expertise. The platform facilitates the identification of relevant regulatory and toxicological changes, but impact assessment remains the responsibility of experts. It is designed as a complement to internal teams and CEHTRA consultants. Contact Book a demo

Request a CEHTRAWATCH demo and discover how the platform helps your teams monitor regulatory and toxicological updates for your substance portfolio. Book a CEHTRAWATCH demo Discover how CEHTRAWATCH can transform regulatory and toxicological monitoring into a structured, automated and actionable process tailored to your substance portfolio. Would you like to see how CEHTRAWATCH can support your regulatory, toxicology, R&D or product stewardship teams? Complete the form to request a personalised demo. Our experts will show you how the platform helps you monitor relevant regulatory and toxicological developments, identify changes affecting your substances and receive targeted alerts. Our team will contact you shortly to arrange the demonstration and better understand your regulatory monitoring needs. Your request will be handled with care and full confidentiality. Your contact details First name* Last name Company* Email* Phone Which sector(s) would you like to explore with CEHTRAWATCH? Autorisation REACH Biocides Chemical REACH Cosmetics Food Industrial hygiene Medical Devices Packaging Pharmaceutics Plant Protection Global chemicals notification Please select your preferred time slot for the demo (based on your local time): Morning (9:00 AM – 12:00 PM) Early afternoon (12:00 PM – 2:00 PM) Late afternoon (2:00 PM – 5:00 PM) Which days work best for you? Monday Tuesday Wednesday Thursday Friday Your needs in a few words Submit

CEHTRA provides regulatory, toxicology and risk assessment expertise for the chemical, biocides, PPP, cosmetics, pharma, food industries, ... Your partner in regulatory compliance and product safety Simplify your regulatory compliance with our expertise and innovative tools. Our sectors Contact us Nos programmes Recognized expertise in Regulatory Affairs and Risk Assessment For over 25 years, CEHTRA has been supporting chemical industry players across key strategic sectors. We assist manufacturers, formulators, distributors, and importers in areas including industrial chemicals (REACH), biocides (BPR), plant protection products (PPP), cosmetics, pharmaceuticals, and food products, including novel foods & supplements, as well as packaging, and other sectors related to health, environmental protection, and product safety. Thanks to our multidisciplinary expertise in toxicology, ecotoxicology, risk assessment and international regulations, we offer tailor-made solutions adapted to the specific requirements of each market, both within and outside Europe. Contact an Expert Our Areas of Expertise biocides Explore chemicals Explore cosmetics Explore food Explore packaging Explore pharmaceuticals Explore plant protection Explore all Explore Digital Solutions for Regulatory Affairs & Toxicology Your performance, our smart solutions. Focus on Directive (EU) 2026/805: Revision of Water Quality Standards and Monitoring Mechanisms Directive (EU) 2026/805 of 30 March 2026 constitutes a major revision of the European Union’s water legislation. By simultaneously amending the Water Framework Directive (2000/60/EC), the Groundwater Directive (2006/118/EC), and the Environmental Quality Standards Directive (2008/105/EC), the text aims to align the protection of water resources with the European Green Deal’s “zero pollution” ambition. TOXICOLOGY How to Integrate Environmental Properties into the Safety Assessment of Cosmetic Ingredients? The safety of cosmetic products is generally assessed from the perspective of human health, considering endpoints such as skin irritation, skin sensitisation, systemic toxicity, and endocrine disruption. However, the environmental properties of cosmetic ingredients are becoming increasingly important in substance assessment processes and product development strategies, particularly when selecting formulation ingredients. COSMETICS China’s MEE Order No. 12: Key Draft Changes to New Chemical Substance Registration China is revising its rules on new chemical substance registration, with a draft revision of the Measures for the Environmental Management Registration of New Chemical Substances, commonly referred to as China REACH. The draft was released by China’s Ministry of Ecology and Environment on 11 June 2026 and was open for public comment until 12 July 2026. Once finalised, the revised measures are expected to replace MEE Order No. 12 of 2020. REGULATORY UPDATES 1 2 3 4 5 Need guidance? Speak with our specialists Select a sector:* First name:* Last name:* Company or Organization:* Email:* How can we help you? Submit

Careers in Regulatory Affairs, Toxicology & Chemical Safety Join CEHTRA, a leading regulatory affairs and toxicology consulting firm. Apply online easily through our application form – no CV upload required. Apply to CEHTRA Would you like to join a recognized consulting firm in regulatory affairs, toxicology and chemical risk assessment? CEHTRA regularly recruits scientific, regulatory and support profiles in France and internationally. Why join CEHTRA? For over 20 years, CEHTRA has been supporting industrial clients in sectors such as: Chemicals Cosmetics Biocides Pharmaceuticals Medical devices Food & feed What we offer: High-level scientific and regulatory projects Recognised European expertise A collaborative and people-focused environment Career development opportunities within a growing international group I am applying for the position of: First name* Last name* Phone* E‑mail* Curriculum Vitae* Import a file Cover Letter (optional) Import a file Apply Julien LEGHAIT "Working in a team with diverse points of view helps me to broaden my vision about things and allows me to take into account the elements that I wouldn’t have thought through otherwise."

Our DNA is international. You can find contact details of all our offices on this page. Our DNA is international Click on the country below for more details North America Europe Asia Canada France Germany Spain India United Kingdom Canada 24 Ivy Lea Crescent Toronto ON M8Y 2B6 Phone: +1 (416) 432-4020 France 126 rue du Landy 93400 Saint-Ouen 15 rue Aristide Briand 33150 Cenon, Bordeaux Phone: +33 (0) 557 77 56 10 8 avenue Leclerc 69007 Lyon Contact - France Germany CEHTRA GmbH Christoph-Probst-Weg 4 20251 Hamburg Phone: +49 ( 0)40 611 35 455 Contact - Germany India CEHTRA Chemical Consultants Pvt. Ltd. B1/A5, Mohan Co-Operative Industrial Estate, New Delhi-110044, INDIA Contact - India Spain Calle Pintor Murillo 29 – oficina bajo A 28100 Alcobendas Madrid Phone: +34 918 429 142 Contact - Spain United Kingdom CEHTRA Limited, Suite 31, 1 Hanley Street, Nottingham NG1 5BL United Kingdom Contact - United Kingdom

Explore CEHTRA’s values: human-centered expertise, sustainable practices, innovation, and digital solutions driving excellence across all sectors. Our Values at CEHTRA A culture built on scientific excellence and regulatory expertise. Inspired by People, Empowered by Science As an international regulatory consulting firm specialised in chemicals, biocides, cosmetics and other sectors, our culture is shaped by collaboration, innovation, and a strong commitment to scientific integrity. Our commitment to corporate social responsibility (CSR) ensures that every decision considers ethical integrity, societal impact, and environmental sustainability. By leveraging technology, we streamline complex regulatory processes, increase transparency, and empower both our teams and clients to make confident, informed decisions. Our Core Values Driving Regulatory Excellence and Human Connection Discover our values in action and hear directly from our teams how they bring them to life every day across all sectors. Collective / Focus Collective Intelligence Collaboration is at the heart of everything we do. We believe that combining diverse expertise and perspectives leads to smarter, more resilient outcomes in every sector we serve. What this means for clients and teams: Encouraging open dialogue and valuing every team member’s contribution Multi-disciplinary teams collaborating across countries and regulatory areas Sharing knowledge openly to empower colleagues and clients alike Client Focus Our clients’ challenges shape our priorities. We go beyond compliance, focusing on human relationships, understanding the people behind every project, and delivering solutions tailored to their needs. What this means: Actively listening to clients’ constraints and goals Providing solutions that simplify work and accelerate decision-making Building long-term partnerships based on trust, empathy, and transparency " Working in a team with diverse points of view helps me to broaden my vision about things and allows me to take into account the elements that I wouldn’t have thought through otherwise." Julien LEGHAIT " Working in a domain where regulatory requirements are continuously evolving, it is my passion to pass the experience and knowledge I have gained so far to our clients. This allows developing regulatory strategies that are optimised to address to specific client needs and further strengthen the collaboration with them." Annekathrin FAUPEL Innovation / Commitment Innovation Innovation is about improving processes, tools, and experiences for everyone involved. By integrating digital solutions, data-driven methods, and creative thinking, we make regulatory compliance more efficient, transparent, and user-friendly. What this means: Developing technology solutions like CEHTRAWATCH to simplify regulatory workflows Encouraging curiosity, experimentation, and forward-thinking in our teams Applying innovation to enhance usability, efficiency, and impact across all sectors Commitment Commitment reflects our ethical responsibility to people, communities, and the environment. Every decision we make considers societal impact, sustainability, and regulatory integrity. What this means: Acting with integrity and accountability in all projects Supporting public health, environmental safety, and societal well-being Committing to develop and maintain a diverse and collective expertise mix across all sectors " Working within a company that welcomes evolution and progressiveness actively encourages us to develop improvements in our day to day working practices, to the benefit of both colleagues and clients." Melanie HARPER " At CEHTRA, our individual and collective ‘commitment to excellence’ drive us to accomplish the regulatory success desired by our satisfied customers " Pramod KUMAR Competency / Transmission Competency Competency at CEHTRA is built on scientific excellence, regulatory knowledge, and continuous learning. Across every sector, our consultants transform complex regulations into practical guidance that is actionable, accurate, and human-centered. What this means: Translating complex rules into clear, practical solutions Providing mentoring, training, and guidance internally and externally Ensuring that every recommendation reflects deep understanding and human awareness Transmission Sharing knowledge ensures that expertise grows sustainably. We empower colleagues, clients, and partners by transferring skills, insights, and best practices. What this means: Passing on our knowledge with enthusiasm, supporting colleagues and clients to grow their expertise Identifying and nurturing talent within our organization to build strong, capable teams Acting as active contributors to the future, fostering innovation, learning, and long-term success " At CEHTRA, we combine our skills on a daily basis to provide technical, scientific, digital and organizational solutions. It is essential to continue to diversify and develop everyone's competences to promote individual development within the company." William BERTRAND " Working in a regulatory domain can be quite challenging, especially when you have to deal with grey zones which are not easy to interpret but here is actually where the magic happens. The discussions and debates that are generated around such topics are very enriching and the knowledge shared between colleagues makes us grow further and allows us to help companies from a 360° approach" Sandra MARTINEZ BOSCH Join CEHTRA: A Company Driven by Scientific Integrity and Human Values Would you like to work in an organisation where science, innovation and collaboration are key drivers? Explore our career opportunities to learn how CEHTRA fosters professional growth and supports the next generation of regulatory experts. Join Our Team and Shape the Future of Regulatory Science

Discover the digital tools developed by CEHTRA to optimise your regulatory procedures and simplify the management of your dossiers. Our digital tools Boost your regulatory performance with our smart, user-friendly solutions. Find your tool Discover our digital solutions and find the tool that fits your regulatory needs. CEHTRAWATCH Simplifying global regulatory compliance with speed and precision. Automated global regulatory watch across 100+ updated lists Customizable monitoring by lists and substances Fast, expert-driven insights in under 30 minutes Discover eD PEDIA Instantly assess endocrine disruption potential and access expert guidance. Instant ED screening Access to curated regulatory & scientific data Downloadable reports & expert support Discover COSMETICK Digital solution for safe, efficient, and compliant cosmetics. Complete toxicological and eco-toxicological profiles Evaluation of cosmetic formulas A dynamic platform Discover PRIMO Unlock the power of cloud technology to manage your worldwide registrations. Secure Data Sharing and Storage Collaborative Project Management Comprehensive Regulatory Data Gap Analysis Discover Smart digital tools for regulatory affairs & compliance. Developed by regulatory experts At CEHTRA, we combine scientific expertise and digital innovation to help you meet increasing regulatory compliance demands with confidence. Our tools are designed to support both routine regulatory tasks and complex compliance challenges, based on real needs identified by our in-house experts. Intuitive interfaces with full support Whether you're managing chemical registrations, conducting risk assessments, or ensuring ongoing regulatory monitoring, our smart solutions help you work more efficiently, reduce errors, and keep your products compliant and safe. Built by scientists, for scientists, CEHTRA’s tools are intuitive, scalable, and ready to boost your performance from day one. Need help? Here are the answers to your questions. Why use digital solutions for regulatory compliance? Digital tools save time, centralize information, reduce human errors, and provide real-time monitoring of regulations, which is essential in a complex and constantly evolving regulatory environment. Who can benefit from CEHTRA’s digital tools? CEHTRA’s digital tools are designed for companies across all sectors, particularly in chemicals, biocides, and cosmetics, that want to simplify regulatory management and improve the efficiency of their internal processes. Are CEHTRA’s digital solutions suitable for both SMEs and large companies? Yes, CEHTRA’s tools are modular and can be used by both SMEs and large companies. They adapt to the specific needs of each organization, offering flexibility, scalability, and ease of use. Contact Don’t see what you need? Ask us

I How to navigate and enter data in IUCLID  Be familiar with the main non-technical sections of a REACH dossier and know how to complete them  Be able to proofread the technical sections of a REACH dossier  Know how to use the various features of IUCLID (exports, validation wizards) Be able to submit a dossier in REACH IT Master IUCLID and register your substances under REACH See sessions Contact us Training > The basics > Master IUCLID and register your substances under REACH Overview Program Audience Trainers Objectives. How to navigate and enter data in IUCLID Be familiar with the main non-technical sections of a REACH dossier and know how to complete them Be able to proofread the technical sections of a REACH dossier Know how to use the various features of IUCLID (exports, validation wizards) Be able to submit a dossier in REACH IT Place Horaire Price Language Access time Online 3h30 from 345€ (HT) French 2 months Register See sessions Objectives. How to navigate and enter data in IUCLID Be familiar with the main non-technical sections of a REACH dossier and know how to complete them Be able to proofread the technical sections of a REACH dossier Know how to use the various features of IUCLID (exports, validation wizards) Be able to submit a dossier in REACH IT Program. Part 1 - Introduction to IUCLID 6 Part 2 - Preparing an IUCLID file: company-specific sections, technical sections, Chesar-IUCLID interaction Part 3 - Validation Wizard and plug-ins? IUCLID Part 4 - Dossier creation and submission on REACH IT Part 5 - Q&A I Assessment of skills acquired through a final quiz Methods used. The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Download the catalogue Audience. Any user of IUCLID 6 to prepare and/or submit REACH dossiers. Prerequisites. Access to IUCLID. Be familiar with the REACH regulation and its requirements. Damien Guyomar Toxicologist What our customers say "I am very satisfied with this course, which was well adapted to my background and met my needs. Furthermore, the distance learning format is entirely satisfactory, and the limited number of trainees facilitates exchanges." La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. See our certificate About CEHTRA We have been specialising for 20 years in assisting companies in the marketing of chemical substances or products in France and also in Europe and outside Europe. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover a dozen sectors including REACH, biocides, plant protection products, etc... +

COSMETICK : l’outil digital tout-en-un pour l’évaluation toxicologique et la sécurité des produits cosmétiques. Profils toxicologiques, éco-toxicologiques, calculs de marges de sécurité (MoS) et préparation du RSPC (CPSR) en quelques clics. COSMETICK: the digital tool for cosmetic compliance and safety A digital solution dedicated to cosmetic risk assessment, integrating structured cosmetic toxicological profiles, the calculation of Margins of Safety (MOS) , and the preparation of Cosmetic Product Safety Reports (CPSR) to ensure regulatory compliance for cosmetics. Discover Book a demo Simplify your cosmetic regulatory compliance with COSMETICK The cosmetics industry faces strict regulatory requirements — especially in Europe under Regulation (EC) No. 1223/2009 , which mandates a Cosmetic Product Safety Report (CPSR) supported by reliable toxicological profiles. COSMETICK is a toxicological database dedicated to cosmetics, combined with a digital cosmetic safety assessment tool. It provides access to structured cosmetic toxicological profiles, enables exposure assessment, supports the calculation of Margins of Safety (MOS), and generates structured documentation to support the preparation of the Cosmetic Product Safety Report (CPSR) in accordance with the EU Cosmetic Regulation. Developed by regulatory toxicologists, COSMETICK supports cosmetic regulatory compliance through a clear and traceable hazard × exposure methodology. Improve efficiency, reduce error risk, and ensure product safety with confidence. Test the substance profile search Key features of COSMETICK: your toxicological assessment tool for cosmetic products A dedicated toxicological database for cosmetics: comprehensive toxicological and ecotoxicological profiles Characterisation of toxicological effects based on structured bibliographic review by endpoint Identification of no-effect levels (NOAELs and reference values) relevant for Margin of Safety (MOS) calculation Integration of key data required for cosmetic safety assessment and CPSR preparation Visual warning system using colour-coded indicators for rapid and structured interpretation For cosmetic formula safety assessment: Margin of Safety (MOS) calculation and CPSR preparation Simplified formula input with product type selection (leave-on / rinse-off) Automated calculation of Margins of Safety (MOS) based on exposure assessment and toxicological profiles Clear regulatory decision-support interface (MOS values, warnings, alerts) Export of a structured pre-filled document to facilitate preparation of the Cosmetic Product Safety Report (CPSR) A dynamic platform supporting cosmetic regulatory compliance Customisation of cosmetic toxicological profiles according to your assessment needs Online submission of new profile requests in just a few clicks Regular updates of the toxicological database Continuous integration of regulatory developments impacting ingredient safety Monthly newsletter dedicated to cosmetic safety and regulatory compliance updates View all features Why users rely on COSMETICK 🧪 Data Reliable profiles ⚖️ Decision Consistent assessments ⚡ Efficiency Faster workflows They trust us. Need help? Here are the answers to your questions. What if an ingredient is not available in the COSMETICK toxicological database? If a cosmetic toxicological profile is not available in the COSMETICK toxicological database, you may submit a request directly via the online form. Each request is reviewed by regulatory toxicologists to ensure that the newly developed profile meets scientific and regulatory standards applicable to cosmetic safety assessment and CPSR preparation. Once validated, the profile is added to the toxicological database. You can track the progress of your request online and will receive an email notification when it becomes available. Does COSMETICK generate a Cosmetic Safety Report (CSR) and safety margins? COSMETICK produces a structured pre-assessment containing the key elements required for preparation of the Cosmetic Product Safety Report (CPSR), in accordance with Annex I of Regulation (EC) No 1223/2009. This pre-assessment includes: Exposure assessment based on the product formulation Calculation of the Margin of Safety (MOS) for each ingredient Evaluation of impurities, including CMR substances (carcinogenic, mutagenic or reprotoxic) Identification of relevant toxicological warnings Justification of skin tolerance Integration of user-specific data (test results, specifications, supplier information) The generated document supports preparation of Part B of the CPSR, which must be reviewed and validated by a qualified safety assessor in accordance with Article 10 of the EU Cosmetic Regulation. Contact Book a demo

Quickly find out if your non-food consumer products are affected by GPSR 2023/988. Complete our free 2-minute assessment and, if needed, get personalized guidance from our CEHTRA expert. Are You Concerned by the GPSR (General Product Safety Regulation)? The General Product Safety Regulation (GPSR – EU Regulation 2023/988) has applied since 13 December 2024. Official guidance documents, published in November 2025, help economic operators understand their new and reinforced obligations when placing consumer products on the EU market. The General Product Safety Regulation (GPSR – EU Regulation 2023/988) has applied since 13 December 2024. Official guidance documents, published in November 2025, help economic operators understand their new and reinforced obligations when placing consumer products on the EU market. Why take this GPSR questionnaire? Understand whether the GPSR applies to your products Clarify your position as a manufacturer, importer, distributor or online seller Identify if you are potentially subject to GPSR obligations Avoid misinterpretation of the regulation’s scope This questionnaire is intended for companies operating on the EU market, including manufacturers, brand owners, importers, distributors and e-commerce players. A quick questionnaire to check whether the GPSR applies to your products What is your main sector? Toys/childcare Textiles/accessories Electronics/electrical goods Household/decorative items Scented items / fragrance diffuser Sports/leisure Other Suivant Learn more about the GPSR For a detailed explanation of the GPSR scope, key concepts and practical implications, we invite you to read our dedicated article. Read the article Need further support? If you have specific questions or would like to discuss your situation, you can also reach out to our regulatory experts via the contact form. Request support

CEHTRA helps chemical and life sciences companies ensure regulatory compliance and accelerate global market access. Regulatory Consulting to Support and Strengthen Your Strategy Anticipate. Comply. Accelerate new market access with confidence. Our services Request support Your partner for comprehensive, secure and sustainable compliance At CEHTRA, we support chemical and life sciences companies navigate the complexities of regulations that are constantly evolving. Our multidisciplinary team of regulatory specialists, toxicologists, ecotoxicologists, and scientific experts helps you anticipate regulatory changes, assess impacts on your products, and implement smart & efficient compliance strategies. With over 25 years of experience, a global footprint and dedicated digital tools, CEHTRA guides you from early strategic planning through to dossier submission and post-approval follow-up — ensuring timely, sustainable, and competitive market access. Contact our experts Our Strategic & Regulatory Services Ancre 1 Regulatory Landscape Analysis Assessment of target markets, identification of applicable requirements, and delivery of critical regulatory insights. Evaluation of current and upcoming regulations affecting your product portfolio, including obligations, risks, opportunities, Data Gap Analysis, and priority actions. Analysis of potential regulatory positioning for your products when multiple frameworks apply. Regulatory Impact Assessment Regulatory Watch Continuous monitoring of legislative updates, scientific guidelines, standards, and methodological developments, with compliance roadmaps adjusted as needed. Regulatory Dossier Preparation, Management & Submission Data generation, including the use of alternative methods (QSARs, read-across, in silico modelling) to minimise animal testing where possible. Preparation and development of regulatory dossiers compliant with regional and international requirements. Submission of dossiers and communication with authorities, including local representation when required. Client & Supplier Data Management Collection, verification, secure handling, and continuous updating of essential data to ensure compliance, traceability, and high-quality regulatory dossiers. Looking for advice on regulatory compliance? You'll find it here. What is strategic regulatory consulting? Strategic regulatory consulting involves analyzing the regulatory landscape, assessing compliance risks, and designing efficient strategies to ensure products meet global regulatory requirements. It helps companies reduce delays, manage risks, and optimize market access. Which industries benefit from CEHTRA’s regulatory services? CEHTRA supports a wide range of sectors, including chemicals, biocides, cosmetics, pharmaceuticals, crop protection, and specialty materials. Any company facing complex regulatory requirements can benefit from tailored compliance and strategic advice. How does CEHTRA help with global market access? CEHTRA provides impact assessments, regulatory monitoring, compliance strategies, and dossier submission support for multiple regions worldwide, including Europe, North America, Asia, LATAM, and more. Local representation and guidance ensure smooth, timely, and compliant market entry. Explore additional resources Can’t find your answer? Submit a request

Explore CEHTRA’s webinars, conferences and regulatory events. Access expert insights on toxicology, chemical regulations and industry trends, live or on demand. CEHTRA Webinars, Conferences & Regulatory Events Discover our latest events, webinars, and insights on regulatory and scientific developments. All events CEHTRA at SETAC Europe 36: Poster Presentation on the “Rapidly Biodegradable” Criterion under the UWWTD CEHTRA is pleased to announce its participation in the SETAC Europe 36th Annual Meeting, taking place from May 19–21, 2026 in Maastricht. During the event, Floriane Demailly and Mylène Léger will present a scientific poster addressing the implementation challenges associated with the new “rapidly biodegradable” criterion introduced under the recast Urban Waste Water Treatment Directive (UWWTD). May 18 1 min read Questions Toxicologists Asked About Cosmetic Safety Assessment – COSMETICK Webinar During our COSMETICK webinar on cosmetic safety assessment, toxicologists raised key questions on endocrine disruption, Margin of Safety (MOS), and toxicological data gaps. Mar 19 4 min read

Regular training is essential to keep up-to-date with the changing regulations.You choose what you want to learn and when. You can come to us or we can come to you. Mentoring Tailor-made training to meet the specific needs of your company. Contact us Training > Mentoring > Tailor-made regulatory training with CEHTRA: Build skills that match your industry challenges At CEHTRA, we understand that every company faces unique regulatory challenges. That’s why we offer customised training programmes, built with you and for you, to meet your specific needs and support your teams effectively. Whether you're navigating new regulations, onboarding staff, or developing in-house expertise, our tailor-made sessions ensure your teams gain the right knowledge at the right time. Tell us about your training goals A fully personalised approach You choose the topics, technical level, language, format (on-site, remote or hybrid), and duration. We design a targeted training programme based on your industry, regulatory priorities, and learning goals. You work directly with a CEHTRA expert to fine-tune the content to your real-life business challenges. Our Areas of expertise Cosmetics. Packaging. Pharmaceutics. Toxicology. Food. Chemicals REACH. Ecotoxicology. Biocides. Medical devices. Plant Protection. La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. See our certificate About CEHTRA We have been specialising for 20 years in assisting companies in the marketing of chemical substances or products in France and also in Europe and outside Europe. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover a dozen sectors including REACH, biocides, plant protection products, etc... +

Welcome to CEHTRA's window to the worldwide regulatory support. Welcome to CEHTRA cker CEHTRA's window to worldwide regulatory support CEHTRAcker Map CEHTRAcker Interactive Map Select a country in the map below to see how CEHTRA can accompany you Locations in green indicate presence of CEHTRA offices Locations in blue indicate services available via CEHTRA's trusted partners Australia The Industrial Chemicals Act 2019, administered by AICIS, came into effect on 01 July 2020 and regulates the importation and manufacture of industrial chemicals in Australia. CEHTRA provides the following services: Categorization of introduction Definition of the scope of assessment (Listed / Exempted / Reported / Assessed) Scientific expertise Data Gap analysis, Testing strategy (incl. alternatives to in vivo testing), Scientific support Dossier preparation Submission and communication with authorities thought a local partner Go back to the interactive map CEHTRAcker Austalia CEHTRAcker Canada Canada Canada’s New Substances Notification (NSN) Regulations, under the Canadian Environmental Protection Act (CEPA), are a tiered system whereby specific data schedules are submitted based on annual volumes, imported or manufactured. The Canadian Authorities evaluate this information to determine if a substance presents an unreasonable risk to human health and/or the environment. Through our office located in Toronto, CEHTRA provides the following services: NSN Notification Strategies Canadian Agent Services NSN Dossier Preparation Communication with Authorities Notification schedule selection, Datagap analysis, Testing strategies (waivers, read-across, QSAR, laboratory testing), Scientific support Acting as authorized representative for clients without a business presence in Canada Compiling and submitting required administrative, hazard, and exposure information, Preparing waiver/read-across arguments Pre- and post- notification consultation with the Canadian Authorities, Confidential DSL Inventory status inquiries Go back to the interactive map China The revised Provisions on the Environmental Administration of New Chemical Substances (MEE Order No. 12) - effective from January 1, 2021 – regulates new chemical substance registration. Through our local partners, CEHTRA can assist you with the following services: Inventory IECSC search Notification R&D notification, Record notification, Simplified and Regular Registration Post-notification Obligations Representative service Annual Report, Certificate Renewal… Go back to the interactive map CEHTRAcker China Eurasia The Technical Regulation of Eurasian Economic Union (EAEU) on Safety of Chemical Products ТR.No.041/2017, known as Eurasia-REACH, approved on March 3rd 2017, deals with the Registration, Evaluation, Authorization, and Restriction of Chemical substances. Through our local partners, CEHTRA can assist you with EAEU dossiers. Inventory Notification Service Safety Data Sheets (SDS) Nominated representative service Late pre-nomination Preparation and/or update of SDS according to the GOST standards Representation of non-Eurasian companies Go back to the interactive map CEHTRAcker Eurasia European Union Through our offices in the EU, CEHTRA can assist you with the following services: Dossier compilation & update SIEF Management Only Representative Supply-chain management Lead registrant and co-registrant dossiers testing strategy Consortium and SIEF communication, administrative and financial management of LoA Representation of non-EU companies through our Only-Representative (OR) Legal Entity and UK-REACH Obligations as EU importer, manufacturer or Downstream-User (DU), notifications to ECHA Click here to be redirected to our page dedicated to EU REACH Go back to the interactive map CEHTRAcker EU India India’s Chemicals (Management And Safety) Rules (ICMSR) also referred to as ‘India REACH’ will come into force on the date of their publication in the Official Gazette, expected mid-2021, and will regulate all substances, substances in mixtures, and intermediates that are manufactured, imported or placed on the market in the Indian territory at quantities greater than 1 tonne per year. Through our office located in New Delhi, CEHTRA provides the following services: Notification/ Registration & update Safety Data Sheets (SDS) Authorized Representative (AR) service Data Management Preparation and update of Notification and Registration dossiers for individual or joint submissions Preparation and/or update of SDS in latest UN-GHS format Representation of non-Indian companies through our Indian entity Arrangement of data on substances already registered with any foreign regulator in other jurisdictions Click here to be redirected to our page dedicated to ICMSR Go back to the interactive map CEHTRAcker India Japan The Chemical Substances Control Law – referred to as CSCL – was firstly enacted in 1973 in Japan to prevent environmental pollution by chemical substances that pose a risk to human health or the environment. CSCL controls both new and existing substances. The Industrial Safety and Health Law – ISHL - was firstly enacted in 1972 to protect the safety and health of workers in workplaces in Japan. IHSL designates substances that are prohibited to manufacture or import, substances requiring permission and chemical substances requiring safety data sheets and labels. ISHL also controls new substances and requires manufacturers and importers to notify them to the Japanese Ministry of Labor and Welfare (MHLW) prior to production and importation. Through our local partners, CEHTRA can assist you with the following services: CSCL notification Standard (full) notification, Low volume notification (LVN), Small volume exemption (SVE), polymer… ISHL notification Standard notification, Low volume notification Safety Data Sheets (SDS) & Label Preparation and/or update of SDS / Label under Japanese standards Go back to the interactive map CEHTRAcker Japan New Zealand Pesticides, household chemicals and other dangerous goods and substances are regulated by the EPA (Environmental Protection Authority) under the Hazardous Substances and New Organisms Act 1996. All hazardous substances require approval in New Zealand prior to use. Depending on the substance and hazard classification, an approval may take the form of an Individual Approval or a Group Standard Approval. CEHTRA provides the following services: NZ GHS Assistance with the classification according to NZ GHS 7 Expertise Providing guidance on the most appropriate approval route Registration support Preparation of paperwork required for approval, including where necessary submission and communication with authorities. Go back to the interactive map CEHTRAcker New Zealand Philippines The Pre-Manufacturing and Pre-Importation Notification, known as PMPIN, aims to screen harmful substances before they enter the Philippine market. CEHTRA provides the following services: Dossier preparation Abbreviated or Detailed PMPIN Dossier submission Through a local partner (Abbreviated or Detailed PMPIN / SQI / PCL / CCO / Polymer) Go back to the interactive map CEHTRAcker Philippines South Korea The Act on Registration and Evaluation, etc. of Chemical Substances – referred to as “ARECs” or “K-REACH” - was implemented on January 1, 2015 by the Ministry of Environment (MOE) with the aim. of protecting public health and the environment by the registration of chemical substances. The Occupational Safety and Health Act - referred to as “OSHA” - is regulated by Ministry of Employment and Labor (MOEL), with the purpose of OSHA to maintain and promote the safety and health of workers by preventing industrial accidents and creating a comfortable working environment through establishing standards on occupational safety and health and clarifying where the responsibility lies. Through our local partners, CEHTRA can assist you with the following services: K-REACH registration KECL inventory search, registration dossiers, communication with MOE/NIER K-REACH OR Representation of non-Korean companies OSHA New Chemical MOEL’s inventory search, dossier preparation, communication with MOEL OSHA GHS GHS classification and preparation of GHS MSDS & Label Go back to the interactive map CEHTRAcker South Korea Taiwan Chemical regulation in Taiwan is covered by the EPA’s Regulation of New and Existing Chemical Substances Registration (Dec 11, 2014 - amended 2019) and the MOL’s Regulation of new chemical substances registration (Jan 1, 2015). Through our local partners, CEHTRA can assist you with the following services: Expertise Identification of regulatory obligations Registration Small Quantity, Simplified and Standard Registration CBI application Post-submission Obligations Annual Reporting Go back to the interactive map CEHTRAcker Taiwan Turkey The regulation Kimyasallarin Kaydi Degerlendirmesi Izni ve Kisitlamasi, known as KKDIK, published on 23rd June 2017 deals with the Registration, Evaluation, Authorization, and Restriction of Chemical substances. Through our local certified partners, CEHTRA can assist you with KKDIK dossiers. Dossier preparation Preparation of registration dossiers for individual or joint submissions SIEF management Safety Data Sheets (SDS) & Label Only representative service Consortium and SIEF communication, administrative and financial management Preparation and/or update of SDS / Label in Turkish language Representation of non-Turkish companies Go back to the interactive map CEHTRAcker Turkey CEHTRAcker UK United Kingdom The Brexit transition deadline of 31 December 2020 is fast approaching and it is vital that companies ensure that they remain compliant beyond this date. CEHTRA team remains available to answer any queries you may have to ensure you are compliant with the new regulatory framework which will apply from 1st January 2021. Through our offices located in the UK and the EU, CEHTRA can assist you with the following services: UK REACH Registration and OR UK REACH OR Consortium Management Click here to get redirected to our page dedicated to Brexit Go back to the interactive map CEHTRAcker USA USA The Lautenberg Chemical Safety Act (LCSA) was signed into law in 2016 to modernize the Toxic Substances Control Act (TSCA). New chemicals are still registered under the Premanufacture Notice (PMN) rules, but now the EPA conducts a risk-based review and must make an affirmative safety determination before they can be imported or manufactured. The LCSA empowers the EPA to request more up-front test data and information to characterize hazards, uses, releases, exposure scenarios, etc., meaning that more knowledge and effort is required to achieve a successful registration than ever. CEHTRA provides the following services: US PMN Strategies TSCA Inventory List status, Datagap analysis/Data quality check, CA chemical name and CAS RN assignment/proof assurance. LCSA Exemption Support PMN Submissions PMN Technical Contact Support Polymer Exemption qualification assessments, Low Volume Exemption applications, R&D/TME/LoREX support Compilation of PMN Form and supporting documentation in e-PMN/CDX, Sustainable Futures modelling Pre-Notice Consultation, Post- submission review support including consent orders and other EPA regulatory actions Go back to the interactive map

egulatory support for food and nutraceutical products: safety, compliance, authorizations, and formulation with CEHTRA. Food supplement formulation, safety assessment, and regulatory guidance Supporting your food and nutraceutical products from safety assessment to market authorization. Our services Request support Ensuring safety and compliance for innovative food ingredients Bringing food and nutraceutical products to market requires a firm guarantee of safety for the end consumer. We support industry players at every stage of ingredient and finished product development, whether for human or animal consumption. From scientific safety validation to the preparation of comprehensive regulatory dossiers and applications for innovative ingredients, our expertise helps you streamline and secure your processes. Our multidisciplinary team of toxicologists, chemists, ecotoxicologists, and in silico analysis specialists combines complementary skills to turn your innovations into compliant, reliable products ready to succeed in the market. Contact our experts Key regulatory services for food and nutraceutical products Ancre 1 New products authorisation Comprehensive support for Novel Foods, NDI, and GRAS dossiers. Guidance on the authorization of GMO products and food/feed additives. Preparation and submission of food and feed authorization applications (EU, USA, UK). Management of communications and follow-up with regulatory authorities. Comprehensive safety dossier Preparation of justification dossiers (dose exceedance, absence of labeling, etc.). Safety evaluation of ingredients, substances, additives, and finished products. Expert support on safety topics: endocrine disruption, NAMs, in silico analysis, etc. Support in establishing safety evaluation strategies for raw materials and finished products. Risk Assessment Risk analysis via dietary exposure (contaminants, active substances, bioactive compounds, etc.). Risk assessment for target populations and species. Formulation Support Assistance in formulating finished products. Safety evaluation of candidate ingredients from the early stages of formulation. Preparation of safety reports for selected ingredients. Event, Novel Food training Novel Food & Toxicological assessment: Selecting, understanding and interpreting key studies Know more Looking for guidance on food supplements? Find it here. How can innovative food and feed products obtain regulatory approval? Innovative food and feed products must obtain regulatory approval before commercialization, which requires demonstrating their high-quality and safety. This involves developing a robust safety assessment strategy to identify and address all potential risks associated with the consumption of these innovations for the relevant populations or species. Our team of experts supports companies throughout the entire process, from defining the toxicological assessment strategy and preparing dossiers to submission and ongoing communication with authorities, ensuring that innovative products reach the market efficiently and safely. What safety dossiers are required for food supplements? Bringing food and nutraceutical products to market requires ensuring their safety for consumers. Safety dossiers are therefore essential to demonstrate the safety of ingredients, substances, additives, and/or finished nutraceutical products. These dossiers rely on toxicological data or in silico analyses and provide scientific justification when required by regulations (for example, in cases of dose exceedance or absence of labeling). We prepare comprehensive safety dossiers tailored to regulatory requirements to support the successful and compliant introduction of your products to the market. At what stage of product development should safety evaluation begin? Safety evaluation should start as early as possible in the product development process. Early assessments help identify potential safety concerns, guide formulation choices, and ensure alignment with regulatory requirements, saving both time and resources when moving toward market approval. Our team can support you throughout this process to secure a smooth and compliant product development pathway. Explore additional resources Can’t find your answer? Submit a request Enhance your regulatory strategy with our complementary services CEHTRA Training. Deepen your knowledge with our expertise. Digital Solutions. Your performance, our digital solutions. Simply Predict. In silico predictions: for faster, smarter decision-making. Flex + Your projects are moving forward. We provide the resources. Endocrine disruptors. The assessment of endocrine disruptors, with rigor and method. Haut de page

Assess the regulatory robustness of your botanical ingredients. Identify risks, gaps and compliance needs with CEHTRA experts. Botanical Ingredients Regulatory Exposure Diagnostic Identify potential regulatory and scientific vulnerabilities Assess the Regulatory Robustness of Your Botanical Ingredients Botanical ingredients are increasingly impacted by scientific reassessments and evolving European regulations. Companies placing botanical substances on the market must ensure that their data, monitoring systems, and regulatory strategies remain robust and up to date. This quick diagnostic helps identify potential areas of vulnerability in the management of your botanical ingredients and determine whether additional expert support may be beneficial. Why This Diagnostic Matters Botanical ingredients can present several regulatory and scientific challenges, including: Limited or fragmented toxicological data Emerging scientific publications and regulatory opinions Variability of botanical extracts and raw materials Changing European regulatory expectations Increasing scrutiny from authorities and stakeholders Identifying potential weaknesses early helps support regulatory compliance, product safety, and long-term market access. 1. Toxicological Data Do you have complete and structured toxicological data for your botanical ingredients? Yes No / partially / scattered Suivant Learn more about regulatory challenges for botanical ingredients Discover how evolving scientific data and European regulatory requirements are impacting the use of botanical ingredients. Our experts explain the key considerations to help you better understand potential risks and strengthen your regulatory strategy. Read the article Need further support? If you have specific questions or would like to discuss your situation, you can also reach out to our regulatory experts via the contact form. Request support

I Understand the role of toxicological studies in Novel Food dossiers. Identify the types of relevant studies depending on the nature of the product. Read and interpret key data from study reports. Identify quality and compliance criteria (OECD, GLP). Efficiently manage and communicate with subcontracted laboratories. Novel Food & Toxicological assessment: Selecting, understanding and interpreting key studies See sessions Contact us Training > The basics > Novel Food & Toxicological assessment: Selecting, understanding and interpreting key studies Overview Program Audience Trainers Objectives. Understand the role of toxicological studies in Novel Food dossiers. Identify the types of relevant studies depending on the nature of the product. Read and interpret key data from study reports. Identify quality and compliance criteria (OECD, GLP). Efficiently manage and communicate with subcontracted laboratories. Place Horaire Price Language Access time Online 7 hours from 690€ (HT) French 2 months Register See sessions Objectives. Understand the role of toxicological studies in Novel Food dossiers. Identify the types of relevant studies depending on the nature of the product. Read and interpret key data from study reports. Identify quality and compliance criteria (OECD, GLP). Efficiently manage and communicate with subcontracted laboratories. Program. Part 1 - Introduction – Context and Regulatory Framework The role of toxicological studies in Novel Food assessments EFSA requirements and relevant guidance documents When studies are required (and when they are not) Part 2 - Assessment of Genotoxic Effects Why EFSA emphasizes genotoxicity Standard studies: Ames test, micronucleus assay, chromosomal aberrations Interpretation of results and acceptability criteria Limitations and interpretation caveats Part 3 - Assessment of Systemic Toxicity Subchronic toxicity studies (90 days – OECD Guideline 408) Key concepts: NOAEL, LOAEL, adverse effects, safety margins Parameters monitored: weight, organs, blood, histopathology, etc. How to read a GLP-compliant study report Part 4 - Assessment of Reproductive and Developmental Toxicity When are these studies required? Types of studies (OECD 421/422, prenatal and postnatal development) Common data gaps and EFSA expectations Strategic considerations: justifying absence or planning studies Part 5 - Toxicokinetic Evaluation Is there a need for ADME / toxicokinetic studies? What parameters are evaluated? How do they impact toxicity studies and risk assessment? Part 6 - Oversight and Management of Outsourced Studies Best practices for overseeing subcontracted studies How to select a laboratory (GLP compliance, Novel Food experience) Key points to validate in a study protocol before initiation Communication and deliverables expected for an EFSA dossier Part 7 - Final Session – Q&A and Exchange Addressing participants’ specific questions Sharing experiences and best practices Methods used. The course is based on a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Download the catalogue Audience. Regulatory Affairs Managers, R&D Project Managers and Quality Managers. Prerequisites. This training course is intended for participants with a basic knowledge of molecular and cellular biology, as well as some understanding of physiology. These prerequisites are essential to ensure a good understanding of the concepts covered, particularly the mechanisms of toxic effects and the interpretation of systemic toxicity data. Marie Liamin Toxicologist - Food safety expert What our customers say "I am very satisfied with this course, which was well adapted to my background and met my needs. Furthermore, the distance learning format is entirely satisfactory, and the limited number of trainees facilitates exchanges." La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. See our certificate About CEHTRA We have been specialising for 20 years in assisting companies in the marketing of chemical substances or products in France and also in Europe and outside Europe. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover a dozen sectors including REACH, biocides, plant protection products, etc... +

Annex VIII to CLP regulation was released in March 2017 to harmonise the variations between poison centre notifications among members states and the new harmonised system came into effective in January 2021 (extended from January 2020). CEHTRA can support as a third party representative to assist in these requirements. EU POISON CENTER NOTIFICATION (PCN) Annex VIII to CLP regulation was released in March 2017 to harmonise the variations between poison centre notifications among members states and the new harmonised system became effective from January 2021 (extended from January 2020). Importers and downstream users placing hazardous mixtures (with a health and/or physical effect classification) on the EU market are to provide specific information on your mixtures to the centralized EU poison centre before placing theses mixture on the market. They will have to: Register a unique formula identifier (UFI), Include the UFI on the label for professional and consumer use, Include the UFI in section 1.1 of the Safety Data Sheet (SDS) for industrial use. Provide and submit to the ECHA harmonised submission portal: The full chemical composition of the mixture Toxicological information of the mixture (SDS Section 11) Product category (according to the new EU product categorization system EUPCS) The safety data sheet and label in the country’s language The UFI (a 16-character alphanumeric code that uniquely identifies a formula (mixture composition) in the EU and can be generated on the UFI generator ECHA created) The obligation lies with EU Legal entity (non-EU supplier of the mixture cannot replace the EU-based duty holder). A duty holder can entrust a third party (e.g. CEHTRA) to complete the PCN on their behalf. Importers and downstream users placing mixtures on the market not already notified under national legislation must comply with Annex VIII of the Regulation from the following dates: Hazardous mixtures for consumer and professional use: January 1, 2021 Hazardous mixtures for industrial use: January 1, 2024. If the mixture is already on the market and already notified to the local poison centre of the Member State, the date of compliance is 1st January 2025. As an Importer or a downstream user placing hazardous mixtures (with a health and/or physical effect classification) on the EU market you need to provide specific information on your mixtures to the centralized EU poison centre before placing these mixtures on the market – known as PCN notification/s. CEHTRA can support as a third party representative to assist in these requirements. Meet our expert Stephane PIERRE stephane.pierre@cehtra.com Key Services Portfolio Review Review Safety data sheets and labels Prepare and submit PCN notification Screen your Portfolio to identify mixtures that require PCN and notification deadlines Full compliance review of SDS and labels Screen for full notification information and generate UFI codes Regulatory support Offer regulatory advice on how best to fulfill obligations Media Flyers Related Sectors Biocides Chemicals (REACH) Plant Protection

I Understanding regulatory procedures for active substances and products  Understanding zonal assessment and dRR dossiers  Understanding the content of dossiers and the pitfalls to avoid Plant Protection Products: from regulation to registration See sessions Contact us Training > The basics > Plant Protection Products: from regulation to registration Overview Program Audience Trainers Objectives. Understanding regulatory procedures for active substances and products Understanding zonal assessment and dRR dossiers Understanding the content of dossiers and the pitfalls to avoid Place Horaire Price Language Access time Online 7 hours from 690€ (HT) French 2 months Register See sessions Objectives. Understanding regulatory procedures for active substances and products Understanding zonal assessment and dRR dossiers Understanding the content of dossiers and the pitfalls to avoid Program. Part 1 - Regulation (EC) No 1107/2009 The main points The different procedures involved Part 2 - Zonal assessment Zonal assessment: North, Centre and South zones: similarities and differences Exchanges between the Notifier and the Competent Authorities Part 3 - Requirements - The Dossier New requirements: for which substances? for which products? Bringing an existing dossier into line with the new regulatory requirements Part 4 - Case studies Part 5 - Q&A I Assessment of skills acquired through a final quiz Methods used. The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Download the catalogue Audience. Regulatory Affairs Officer in charge of Products/Active Substances. Prerequisites. Scientific background. Beginner in regulatory affairs for plant protection products. Estelle Beltran Head of Plant Protection Products Steffie Segelle Regulatory Affairs Specialist What our customers say "I am very satisfied with this course, which was well adapted to my background and met my needs. Furthermore, the distance learning format is entirely satisfactory, and the limited number of trainees facilitates exchanges." La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. See our certificate About CEHTRA We have been specialising for 20 years in assisting companies in the marketing of chemical substances or products in France and also in Europe and outside Europe. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover a dozen sectors including REACH, biocides, plant protection products, etc... +

Flex+ by CEHTRA lets you outsource resources and strengthen your teams with qualified regulatory, toxicology, and compliance experts. Short or long-term assignments, on-site or remote, all backed by CEHTRA’s quality standards. Flex+ by CEHTRA: Externalize your resources with confidence Flex+ provides qualified experts to reinforce your teams in regulatory, safety, and environmental projects. Short- or long-term missions, on-site or remote, all backed by CEHTRA’s quality standards. Our services Discover Flex+ Boost Your Projects with On-Demand Regulatory Experts At CEHTRA, we know that regulatory projects evolve quickly. With Flex+, our flexible staff augmentation and resource outsourcing service, you can strengthen your teams with top regulatory experts without compromising quality or efficiency. Flex+ covers CEHTRA’s full range of services: toxicology, ecotoxicology, regulatory affairs, product stewardship, and compliance. Our experts quickly integrate into your teams to ensure project continuity and regulatory reliability. Contact our experts Why Choose Flex+? Ancre 1 Regulatory experts on demand Call on specialists in chemicals, biocides, cosmetics, pharmaceuticals or other sectors exactly when your project needs them. Time and efficiency savings Our experts integrate seamlessly into your team to help you meet deadlines and regulatory obligations. Full flexibility Scale the duration and level of involvement according to your project requirements, from short-term support to long-term assignments. Cost optimization Avoid long recruitment cycles and benefit from an agile, budget-friendly solution. How Flex+ Works Discover Flex+ 01. Needs assessment We define the skills and mission duration required for your project. 03. Candidate Presentation & Validation You’ll receive a curated shortlist, complete with detailed competencies and fit assessments. 02. Candidate Sourcing & Screening We use our industry network and recruitment tools to find the best candidate profiles. 04. Integration & Continuous Support Flex+ manages HR tasks, integrates experts seamlessly, and ensures ongoing support for successful project delivery.

Support customer acquisition activities through prospecting, CRM management, and event coordination. Join an international environment and contribute to business development and lead generation projects. Sales Assistant M/F Customer Acquisition - Work-Study Program Paris ASAP Return to all positions Apply Purpose To develop CEHTRA’s client portfolio by leveraging various channels, including organizing meetings with new prospects for market managers and actively participating in industry conferences and events. The objectives are to (a) secure meetings with new prospects and (b) proactively prepare conferences to anticipate and schedule business meetings during these events. Key Responsibilities Identify, contact, and arrange meetings with new prospects Use, update, and optimize the CRM to track all activities (emails, calls, etc.) Plan and coordinate CEHTRA’s participation in conferences and industry events Propose and implement new client acquisition channels: digital marketing, AI-assisted sales, SEO tools, etc. Education BTS or equivalent in business, technical sales, executive assistance, or a related field Hard Skills Fluent English Proficiency in Microsoft Office Experience with a CRM is a plus (e.g. Zoho) Experience First experience is a plus Soft skills Comfortable on the phone Strong client relationship skills Organized and detail-oriented Autonomous Team player Results-driven with a taste for challenge Benefits Why join CEHTRA? High profit-sharing based on economic and climate objectives Additional leave (JNT/RTT) 100% employer-covered health insurance Remote work: 2 days per week Seniority bonus Meal vouchers covered at 60% Sustainable mobility allowance Employee savings plan with employer contribution Works council (CSE) ticketing benefits Sports: challenges and discounted rates Unlimited tea and coffee CEHTRA is a leading European consultancy in regulatory, toxicological, and ecotoxicological sciences, committed to climate action and biodiversity protection. Our mission is to prevent toxicological risks to human health while addressing key challenges such as nanoparticles, endocrine disruptors, and PFAS. Part of the H2B Group, a fast-growing group focused on emerging environmental and health risks, CEHTRA offers diverse and rewarding career paths in both technical expertise and project management. With offices in Bordeaux, Lyon, Paris, Germany, Spain, the UK, Canada, and India, CEHTRA operates across high-growth sectors including chemicals, cosmetics, biocides, pharmaceuticals, food, plant protection, packaging, and medical devices.

Careers in Regulatory Affairs, Toxicology & Chemical Safety Join CEHTRA, a leading regulatory affairs and toxicology consulting firm. Apply online easily through our application form – no CV upload required. Apply to CEHTRA Would you like to join a recognized consulting firm in regulatory affairs, toxicology and chemical risk assessment? CEHTRA regularly recruits scientific, regulatory and support profiles in France and internationally. Why join CEHTRA? For over 20 years, CEHTRA has been supporting industrial clients in sectors such as: Chemicals Cosmetics Biocides Pharmaceuticals Medical devices Food & feed What we offer: High-level scientific and regulatory projects Recognised European expertise A collaborative and people-focused environment Career development opportunities within a growing international group I am applying for the position of: First name* Last name* Phone* E‑mail* Curriculum Vitae* Import a file Cover Letter (optional) Import a file Apply Julien LEGHAIT "Working in a team with diverse points of view helps me to broaden my vision about things and allows me to take into account the elements that I wouldn’t have thought through otherwise."

I Knowing and understanding Cosmetics Regulation 1223/2009  Understand the risk assessment of a cosmetic product  Identify areas for improvement in order to comply with regulatory obligations Safer cosmetics for tomorrow - Know your regulatory obligations See sessions Contact us Training > The basics > Safer cosmetics for tomorrow - Know your regulatory obligations Overview Program Audience Trainers Objectives. Knowing and understanding Cosmetics Regulation 1223/2009 Understand the risk assessment of a cosmetic product Identify areas for improvement in order to comply with regulatory obligations Place Horaire Price Language Access time 7 hours from 690€ (HT) French 2 months Register See sessions Objectives. Knowing and understanding Cosmetics Regulation 1223/2009 Understand the risk assessment of a cosmetic product Identify areas for improvement in order to comply with regulatory obligations Program. Part 1 - Regulatory context for cosmetic products (Europe and other countries) European Cosmetics Regulation n° 1223/2009 - Scope / Borderline products - Cosmetovigilance - Management of updates Part 2 - Cosmetic product safety report - Notion of safety assessment: MoS calculation, local tolerance, etc. - Toxicological profiles of ingredients Part 3 - Specific cases - Baby products, perfumes - In silico Part 4 - Q&A I Assessment of knowledge acquired through a final quiz Methods used. The course is based on a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Download the catalogue Audience. R&D, Regulatory, Quality, Safety Assessors, Manufacturers, Distributors, Subcontractors, Suppliers, Importers. Prerequisites. Cosmetics regulatory affairs officer or toxicologist. Florian Gautier Head of Cosmetics What our customers say "I am very satisfied with this course, which was well adapted to my background and met my needs. Furthermore, the distance learning format is entirely satisfactory, and the limited number of trainees facilitates exchanges." La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. See our certificate About CEHTRA We have been specialising for 20 years in assisting companies in the marketing of chemical substances or products in France and also in Europe and outside Europe. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover a dozen sectors including REACH, biocides, plant protection products, etc... +

If you have questions, feel free to get in touch with our team by filling in the query form and our team will get back to you. Talk to our experts Reach out to our experts for strategic regulatory advice across all sectors we serve — including chemicals, biocides, pharmaceuticals, and cosmetics. If you need tailored regulatory advice, technical support, have a general inquiry, or simply want to learn more about our services, don’t hesitate to contact us using the form below. We do our best to respond within one business day. Your inquiry will be handled with care and full confidentiality. Select a sector:* First name:* Last name:* Company or Organization:* Email:* How can we help you? Submit

CEHTRA and is able to offer Only Representative services under REACH as well as Article 95 Representation under both the EU and UK BPR. With the assistance of locally based partners, we are also in a position to offer representative services in Korea, Russia and Turkey Market Access & Regulatory Representation for Global Suppliers Supporting manufacturers and importers under EU REACH, UK REACH, BPR, K-REACH, KKDIK and global chemical regulations. Our services Request support Only Representative & Global Regulatory Representation Services Representation enables companies to place substances on markets where they do not have a legal presence, ensuring compliance while maintaining commercial flexibility. This approach provides several benefits, including the protection of confidential business information and the ability to supply multiple customers within a country or economic area under a single registration. In the EU, this role is known as the Only Representative (OR), allowing non-EU manufacturers to appoint a qualified entity to fulfill their regulatory obligations under REACH. Similar forms of representation exist in other jurisdictions, supporting international market access and regulatory compliance. CEHTRA operates in both the EU and the UK, offering Only Representative services under REACH as well as Article 95 representation under both the EU and UK Biocidal Product Regulations (BPR). Through strong partnerships with local experts, we also provide representation services in Korea, Russia, and Turkey to support global chemical market expansion. Contact our experts Our Representation Services Ancre 1 EU REACH Only Representative / Article 95 Acting as an OR for non-EU companies to manage REACH obligations, submissions, and compliance across the EU and EEA. K-REACH Representative Assisting manufacturers with representation and compliance under Korea’s K-REACH regulations. SDS & Safety Communication Management Preparing Safety Data Sheets and ensuring proper communication of safety information to authorities and customers. UK REACH Only Representative / Article 95 Providing OR services and regulatory support for UK REACH compliance, including post-Brexit obligations. KKDIK / Turkish Representative Managing regulatory representation and compliance for substances, mixtures, and articles under Turkey’s KKDIK framework. Official Industry & Authority Communication Role Acting as the primary point of contact between companies, regulators, and industry stakeholders for all representation-related matters.

I Understand the obligations under REACH How to use CHESAR to carry out a CSA (Chemical Safety Assessment)  Be able to generate a CSR (Chemical Safety Report) under CHESAR  Comply with ECHA expectations Master CHESAR to simplify your REACH assessments See sessions Contact us Training > The basics > Master CHESAR to simplify your REACH assessments Overview Program Audience Trainers Objectives. Understand the obligations under REACH How to use CHESAR to carry out a CSA (Chemical Safety Assessment) Be able to generate a CSR (Chemical Safety Report) under CHESAR Comply with ECHA expectations Place Horaire Price Language Access time Online 10h30 hours from 1035€ (HT) French 2 months Register See sessions Objectives. Understand the obligations under REACH How to use CHESAR to carry out a CSA (Chemical Safety Assessment) Be able to generate a CSR (Chemical Safety Report) under CHESAR Comply with ECHA expectations Program. Part 1 - Obligations under REACH with regard to CSR Part 2 - Definition and construction stages of the CSA Part 3 - Occupational risk assessment Part 4 - Consumer risk assessment Part 5 - Environmental risk assessment Part 6 - Creation of the complete CSR and compliance with ECHA controls Part 7 - Q&A I Assessment of skills acquired through a final quiz Methods used. The training focuses on version 3.9 of Chesar, as the new online platform is not yet fully operational and currently offers limited functionalities. The course is delivered through a presentation featuring case studies, role-playing exercises and ongoing interaction with the expert. Trainees will receive the course materials, and a final quiz will be used to assess and validate the knowledge acquired. To encourage interaction and enhance the learning experience, our online courses are delivered synchronously in small groups of three to six participants. Download the catalogue Audience. People working on REACH regulations: - Regulatory affairs officer - Toxicologist - Ecotoxicologist - QHSE Prerequisites. Notions on REACH regulations. Anna Chelle Expologist and regulatory toxicologist What our customers say "I am very satisfied with this course, which was well adapted to my background and met my needs. Furthermore, the distance learning format is entirely satisfactory, and the limited number of trainees facilitates exchanges." La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. See our certificate About CEHTRA We have been specialising for 20 years in assisting companies in the marketing of chemical substances or products in France and also in Europe and outside Europe. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover a dozen sectors including REACH, biocides, plant protection products, etc... +

CEHTRA ensures the regulatory compliance of your packaging. Our experts can assist you with your declarations of conformity and with the risk assessment of your products. Our offer extends to laboratory testing, migration modeling and toxicological expertise. Packaging regulatory compliance and safety expertise for global markets Helping you ensure safe and compliant packaging, worldwide. Our services Request support Comprehensive regulatory services for safe and compliant packaging Packaging compliance with current regulations is no longer just a constraint; it has become a strategic level for performance, innovation and differentiation for all industrial players, regardless of their sector or position in the value chain. It now directly conditions the durability of products in the face of evolving regulatory requirements, as well as the growing expectations of the market and end customers. Our team of experts supports packaging manufacturers, suppliers and users in securing their regulatory compliance, while ensuring the long-term sustainability of their products in line with market requirements and customer expectations. Contact our experts Key regulatory services for packaging materials Ancre 1 Packaging regulatory watch Consumer safety: food contact, cosmetics, substances (SOC), REACH / CLP Environment: packaging regulations (PPWR, EPR, etc.) Geographical scope: Europe, USA, China Monitoring formats: monthly, standard or tailor-made Global PPWR / EPR compliance support Regulatory watch & country fact sheets: monthly monitoring and summary of requirements by country Customized dashboard: audit, deviations, and compliance roadmap Tailor-made training & webinars Expert support: dedicated ressource or ad hoc on PPWR / REP subjects Food Contact Packaging Compliance Supplier files: collection, drafting of questionnaires and certificate analysis Declarations of conformity: drafting and review of the DoC food contact (1935/2004/EC, 10/2011/EC, FDA, etc.) Migration & laboratory tests: test management (global/specific migration) and migration modeling Regulatory synthesis of requirements: summary by materials and geographical areas Cosmetic packaging compliance Supplier files: collection, questionnaires and certificate analysis Containment/Content Interactions: Substance Identification and Risk Assessment Exposure assessment: substance-by-substance analysis according to consumer use Tests & compatibility monitoring: laboratory management (Cosmetopack guidelines, adapted tests) Packaging Regulations Webinars and Training Staying up to date with packaging regulations is essential for companies that bring products to market. Our webinars and training courses enable professionals to understand key requirements, anticipate regulatory changes and ensure the compliance of their packaging. Led by regulatory experts, these sessions cover topics such as the regulation of food contact packaging and cosmetics, extended producer responsibility (EPR) and the enforcement of the PPWR Regulation (EU) 2025/40, offering practical advice for an effective compliance strategy. Free PPWR Webinar: Understanding the Packaging and Packaging Waste Regulation Know more Introduction to packaging regulations:understanding and implementing them Know more Regulations in Europe and the USA for recycled plastics intended for contact with food and in cosmetics Know more Looking for guidance on packaging compliance? Find it here. How can I ensure packaging safety and compliance with international regulations? Ensuring packaging safety starts with understanding global regulatory requirements. Our experts help review declarations of compliance, draft specifications, and monitor regulations across EU, USA, China, Switzerland, and Mercosur. By combining document assessment, supplier data collection, and risk evaluation, we provide practical guidance to keep your packaging materials safe and compliant worldwide. How can I ensure packaging safety for food contact materials? Ensuring the safety of food contact packaging requires compliance with specific regulations and careful material assessment. Our experts evaluate substances, perform risk assessments, and monitor interactions between packaging and food. We also guide you through documentation, declarations of compliance, and migration modeling to guarantee that your packaging is safe, compliant, and suitable for food applications. What does the new PPWR regulation mean for packaging compliance? The Packaging and Packaging Waste Regulation (PPWR) sets strict requirements for packaging design, recyclability, and material safety across the EU. Our experts help manufacturers and suppliers understand PPWR obligations, assess packaging safety, and implement compliant solutions. We provide guidance on restricted substances, documentation, and material selection to ensure your packaging meets regulatory requirements while supporting sustainability goals. Explore additional resources Can’t find your answer? Submit a request Enhance your regulatory strategy with our complementary services CEHTRA Training. Deepen your knowledge with our expertise. Digital Solutions. Your performance, our digital solutions. Simply Predict. In silico predictions: for faster, smarter decision-making. Flex + Your projects are moving forward. We provide the resources. Endocrine disruptors. The assessment of endocrine disruptors, with rigor and method. Haut de page

Explore career opportunities at CEHTRA, including roles for ecotoxicologists, toxicologists, physico-chemical experts and regulatory consultants. Join our international team committed to chemical safety and apply today. Join our team at CEHTRA Explore exciting job opportunities at CEHTRA for toxicologists, ecotoxicologists, regulatory affairs experts, engineers, and more — across 10 key sectors including REACH, biocides, cosmetics, and beyond. Filter by sector Digital Marketing Marketing Digital Sales Digital Marketing Internship (Work-Study Program) Digital Marketing, Marketing Digital Work-study program, Alternance Paris, Lyon ASAP Apply Read more Sales Assistant M/F Customer Acquisition - Work-Study Program Sales Work-study program, Alternance, Bachelor's degree (Bac+3) Paris ASAP Apply Read more Careers at CEHTRA: What our team says Julien LEGHAIT "Working in a team with diverse points of view helps me to broaden my vision about things and allows me to take into account the elements that I wouldn’t have thought through otherwise."

CEHTRA is an international leader in technical and regulatory support with regard to the safety of chemical products. Our focus is on scientific and innovative solutions ensuring regulatory compliance of chemicals to international obligations: from portfolio strategy to notification of chemicals and OUR EXPERTISE Biocides Are you required to renew an approval of an active substance, to submit a product authorisation or BPF dossier, to apply for Article 95 List inclusion or for Technical Equivalence? Chemicals (REACH) A solid, highly experienced team focussed on helping you meet your compliance deadline. Cosmetics Demonstrate the safety of both your finished products and ingredients. Get the packaging safety tested. Shorten the time to market. Global Chemicals Notification Our internal tools designed to provide you the best worldwide, personalized and optimized strategy for a minimum cost. Industrial Hygiene CEHTRA's industrial hygienists have decades of experience working with clients in their industrial sites and manage Environmental, Health and Safety challenges with a well balanced mix of technical expertise and practical experience. Packaging Experienced, quality support in managing complex and constantly evolving regulation on packaging. Pharmaceuticals For the safety of your pharmaceutical substances & products we can assist you in the development of your new drugs, safety of your drug production and generation of environmental risk assessment. Plant Protection As a manufacturer or a distributor in the field of agriculture, you want to get your substances approved efficiently and get your Plant Protection Products on the market. REACH Authorisation REACH Authorisation is an European risk management measure which aims to limit human and environmental exposure to substances considered of very high concern.

CEHTRA stands for Consultancy for Environmental & Human Toxicology and Risk Assessment. Since 2001, we provide high quality scientific and innovative solutions ensuring regulatory compliance of chemicals to international obligations. Legal This website is hosted by WIX.com Inc. 500 Terry A François Blvd San Francisco, CA 94158, USA CEHTRA - Consultancy for Environmental & Human Toxicology and Risk Assessment CEHTRA Company information CEHTRA SAS 15 rue Aristide Briand 33150 Cenon France Tel: +33 (0) 557 77 56 10 Fax: +33 (0) 557 77 56 20 contact@cehtra.com Reference : CEHTRA SAS Capital social : 16 000 € RCS Bordeaux 434 733 440 TVA FR 24 434 733 440 APE: 7490B SIRET: 434 733 440 00086 Web Hosting :ONLINE SAS B.P. 438 75366 Paris Cedex 08 www.online.net The following terms of use are applicable to the website www.cehtra.com . This website is designed for a French audience and/or people located in France however the terms of use applicable to other countries and regions around the world can vary. Website The website www.cehtra.com is a company presentation site. CEHTRA could never be held responsible for any direct or indirect damages, whatever the cause, origin or nature and consequence, ensued from the consult or use of the website. In particular, CEHTRA accepts no responsibility in case of an interruption or the inability to access the website, bugs, and any other damages arising from the fraudulent actions of third party from the website. Privacy policy - Personal data All personal data collected on the site are treated with the strictest confidentiality. We remind you that you have a right of access, modification, correction and suppression of the data which concern you (art. 34 of the law "Informatique et Libertés" of January 6, 1978). To exercise this right, please contact us. CEHTRA SAS 15 rue Aristide Briand 33150 Cenon France Tel : +33 (0) 557 77 56 10 Fax : +33 (0) 557 77 56 20 contact@cehtra.com READ MORE ABOUT DATA PRIVACY Guarantees and responsibilities CEHTRA endeavors to assure at best that the information at your disposal through the website is accurate and updated. However CEHTRA does not guarantee in any way that the information are accurate, complete and updated. CEHTRA does not insure any tacit or expressed guarantee regarding the whole or a part of the website. Intellectual property and right The website are hosted by the company CEHTRA: biocide-consulting.com cehtra.co.uk cehtra.com cehtra.eu cehtra.fr consulting-reach.com environment-consultancy.com net-reach.eu pesticide-consulting.com reach-chemical-consulting.com reach-expert.com toxicology-consultancy.com The website is an intellectual creation and is under the intellectual property laws. The whole website and each of its components (texts, schemas, software, codes, photos, drawings, logos, brands and models) are the exclusive property of CEHTRA which is the only one empowered to use the relevant intellectual property rights. Guarantees and responsibilities CEHTRA endeavors to assure at best that the information at your disposal through the website is accurate and updated. However CEHTRA does not guarantee in any way that the information are accurate, complete and updated. CEHTRA does not insure any tacit or expressed guarantee regarding the whole or a part of the website. Disputes The previous terms are stated according to the French right and in particular the measures of the law n°2004-575 of the 21st June 2004 for the trust in the digital economy and the lawi n°78-17 of the 6t January 1978 modified by the law n°2004-801 of the 6th August 2004 IT and Freedom. The jurisdictions Sainte Eulalie have the ability to know all the disputes regarding the website. Conditions Générales d’Utilisation des applications de CEHTRA Mentions légales des applications de CEHTRA