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CEHTRA stands for Consultancy for Environmental & Human Toxicology and Risk Assessment. Since 2001, we provide high quality scientific and innovative solutions ensuring regulatory compliance of chemicals to international obligations (Biocides, Cosmetics, Plant Protection, Reach,...). Votre partenaire en conformité règlementaire et sécurité des produits Simplifiez vos démarches règlementaires avec notre expertise et nos outils innovants Contactez-nous Conseil, Expertise, Logiciels pour répondre à vos besoins Depuis plus de 20 ans, CEHTRA accompagne les industriels avec une expertise réglementaire complète pour la mise sur le marché de leurs produits. Entreprise française de l’économie sociale et solidaire, CEHTRA (Consultancy for Environmental & Human Toxicology and Risk Assessment) est aujourd’hui un acteur de référence, leader en France et troisième au niveau mondial, dans l’assistance technique et le conseil en réglementation, toxicologie et écotoxicologie appliqués aux secteurs de la chimie. Réglementation et Conformité Toxicologie et Ecotixologie Evaluation du risque et exposition Logiciels et solutions digitales Prédictions in silico (Simply Predict) Evaluation des perturbateurs endocriniens Externalisation des ressources Formations Pause Nos secteurs d'intervention Une couverture réglementaire étendues Produits Biocides Produits Chimiques (REACH) Produits Cosmétiques Dispositifs Médicaux Hygiène Industrielle Produits Pharmaceutiques Produits Alimentaires Produits Phytosanitaires Emballages Produits Autorisation REACH Ils nous font confiance To play, press and hold the enter key. To stop, release the enter key. CEHTRA Groupe Une synergie d'experts CEHTRA fait partie du Groupe H2B, un acteur spécialisé dans les essais, l’inspection et la certification pour répondre aux enjeux de santé et d’environnement. À taille humaine, H2B s’engage dans une stratégie de transition digitale, plaçant l’innovation au cœur de ses solutions. En tant que pôle réglementaire du groupe, CEHTRA englobe CAP COMPLIANCE et PROSACON, renforçant ainsi son expertise et sa capacité d’accompagnement sur l’ensemble du cycle de vie des produits chimiques. Grâce à cette synergie, nous proposons des solutions globales et adaptées aux défis réglementaires et scientifiques de nos clients. Dernières actualités et ressources réglementaires Publication of the SCCS preliminary opinion on alpha-arbutin and beta-arbutin Alpha-arbutin and beta-arbutin (INCI: ALPHA-ARBUTIN and ARBUTIN) are two substances of interest for their lightening action via a... 4 days ago Gérez votre blog depuis votre site live Nous vous permettons de gérer votre blog facilement et efficacement ! Veuillez d'abord publier votre site puis connectez-vous directement... May 13, 2020 Créez un superbe blog Choisissez parmi 8 superbes mises en page pour créer votre Wix Blog. Vous trouverez un style pour tous les goûts. Branché ou classique,... May 13, 2020

CEHTRA stands for Consultancy for Environmental & Human Toxicology and Risk Assessment. Since 2001, we provide high quality scientific and innovative solutions ensuring regulatory compliance of chemicals to international obligations (Biocides, Cosmetics, Plant Protection, Reach,...). Accueil > Secteur Cosmétique Produits cosmétiques : de la formulation à la mise sur le marché Accompagnement réglementaire personnalisé pour vos produits cosmétiques – sécurité, conformité, succès Nos services CEHTRA accompagne les entreprises de l’industrie cosmétique – start-ups, PME et groupes internationaux – dans l’évaluation de la sécurité et la conformité réglementaire de leurs produits à l’échelle européenne et internationale. Nos experts interviennent sur une large gamme de produits (soins, hygiène, parfums) et d’ingrédients, en s’appuyant sur des bases de données complètes et des méthodes alternatives (QSAR, read-across, alertes structurelles) pour pallier les données manquantes. Engagés pour une cosmétique plus durable, nous proposons des prestations en écotoxicologie via notre outil COSMETICK, une solution digitale qui fournit des profils écotoxicologiques et des alertes sur les risques environnementaux. Notre équipe Clarisse Bavoux Head of Cosmetic Sector Contactez notre expert 4 toxicologistes 2 écotoxicologistes 3 physico-chimistes 2 spécialistes environnementaux 2 spécialistes efficacité 6 spécialistes en affaires réglementaires Ingrédients, Matières premières Profils toxicologiques Profils écotoxicologiques Identification des concentrations sans risques pour les usages cosmétiques Produits cosmétiques et formulations Pré-évaluations Rapport de sécurité Produits coméstiques Nos solutions pour les produits cosmétiques Ingrédients en cours de développement Stratégie d'essais Approche in silico Données complémentaires Dossier final Logiciel - Cosmetick Base de donnée Alertes réglementaires Suivi de formulation Soutien aux questions toxicologiques et écotoxicologiques Recherche documentaire, bibiliographie Tests in vitro : analyse et conseil Gestion des manques de données par des méthodes alternatives (Read-Across, approche in silico) Produits cosmétiques et formulations Pré-évaluations Rapport de sécurité Produits coméstiques Ingrédients en cours de développement Stratégie d'essais Approche in silico Données complémentaires Dossier final Logiciel - Cosmetick Base de donnée Alertes réglementaires Suivi de formulation Ingrédients, Matières premières Profils toxicologiques Profils écotoxicologiques Identification des concentrations sans risques pour les usages cosmétiques Soutien aux questions toxicologiques et écotoxicologiques Recherche documentaire, bibiliographie Tests in vitro : analyse et conseil Gestion des manques de données par des méthodes alternatives (Read-Across, approche in silico) Nos solutions pour les produits cosmétiques Nos services complémentaires Prédictions in silico Evaluation Perturbateurs Endocreniens Externalisation Formations Logiciels Solutions Digitales Vous vous posez des questions ? Dernières actualités et ressources réglementaires Publication of the SCCS preliminary opinion on alpha-arbutin and beta-arbutin Alpha-arbutin and beta-arbutin (INCI: ALPHA-ARBUTIN and ARBUTIN) are two substances of interest for their lightening action via a... 4 days ago Gérez votre blog depuis votre site live Nous vous permettons de gérer votre blog facilement et efficacement ! Veuillez d'abord publier votre site puis connectez-vous directement... May 13, 2020 Créez un superbe blog Choisissez parmi 8 superbes mises en page pour créer votre Wix Blog. Vous trouverez un style pour tous les goûts. Branché ou classique,... May 13, 2020

CEHTRA stands for Consultancy for Environmental & Human Toxicology and Risk Assessment. Since 2001, we provide high quality scientific and innovative solutions ensuring regulatory compliance of chemicals to international obligations (Biocides, Cosmetics, Plant Protection, Reach,...). Accueil > Logiciels > Cosmetick Simplifer la conformité de vos produits comsétiques Un logiciel conçu pour vous aider à gérer la réglementation cosmétique, sécuriser vos formules et accélérer votre mise sur le marché. Découvrir Réserver une démo Simplifiez votre conformité cosmétique avec Cosmetick Le secteur cosmétique est encadré par des exigences réglementaires strictes, en particulier en Europe avec le Règlement (CE) n°1223/2009. Cosmetick est la solution digitale tout-en-un qui centralise, automatise et sécurise la gestion de vos obligations réglementaires. Conçu pour les fabricants, formulateurs, toxicologues et responsables réglementaires, Cosmetick vous accompagne à chaque étape du cycle de vie produit — de la formulation à la mise sur le marché. Gagnez en efficacité, limitez les risques d’erreurs et assurez la conformité de vos produits en toute sérénité. Tester la recherche de profil de substance Toutes les fonctions de Cosmetick : votre outil de référence pour les produits cosmétiques Gestion des ingrédients et formules en temps réel Validation instantanée des ingrédients en fonction des réglementations en vigueur Alertes automatiques en cas de restriction ou d’interdiction d’un ingrédient Compatibilité internationale pour s’adapter aux réglementations mondiales Dossier d’Information Produit (DIP) Automatisé Génération rapide et conforme aux exigences du Règlement (CE) n°1223/2009 Centralisation des analyses toxicologiques et tests de sécurité Export facilité vers le Cosmetic Product Notification Portal (CPNP) Veille réglementaire et conformité sécurisée Base de données mise à jour en continu avec les dernières évolutions réglementaires Suivi des modifications réglementaires impactant vos formules Audit et traçabilité pour une conformité sans faille Ils ont choisi Cosmetick : découvrez leurs retours "COSMETICK Advanced is a very useful tool for any cosmetic products safety assessor : all required data are gathered (very complete toxicological profils but also ecotoxicity data and regulation alerts). The tool can be used to assess the systemic risk of products ingredients and impurities. It also provides local tolerance alerts. It is very easy to use and a great help when you start working on a new project." Choisissez la formule qui vous convient. Toxicological profiles for ingredients and impurities, text and values Yes Yes Addition of specific confidential data: text and values No Yes Toxicological profiles: export in a Word forma No Yes Eco-toxicological profiles for ingredients and impurities No Yes CEHTRAPEDIA: consultation of information from regulatory and toxicological sources of data Yes Yes Raw Materials: composition (in some conditions related to confidentiality) No Yes Creation of a cosmetic project (formula) with its Raw Materials/ or: INCI formulas No Yes Export of semi-automated toxicological assessment in Word format No Yes Ecotoxicological results on a formula No Yes Analysis of the impact of toxicological changes on a previous report No Yes Notification of updated toxicological data Yes Yes Monthly newsletter related to updates and new profiles Yes Yes Requests of updates and new toxicological profiles Yes * Yes * Requests of updates and new eco- toxicological profiles No Yes * Advanced Choisir Basic Choisir En savoir plus sur les fonctionnalités Vous vous posez des questions ? Découvrir Réserver une démo

I Understand the regulatory procedures for active substances and for products Understand zonal evaluation and dRR dossiers Understand the content of the dossiers and the pitfalls to avoid Plant Protection Products: from regulation to registration Discover Plant Protection Products: from regulation to registration The basics > Ancre 1 Training > Overview Objectives I Skills and Abilities Understand the regulatory procedures for active substances and for products Understand zonal evaluation and dRR dossiers Understand the content of the dossiers and the pitfalls to avoid Program Part 1 - Regulation (EC) No 1107/2009 The main points The different procedures involved Part 2 - Zonal assessment Zonal evaluation: North, Central and South zones: similarities and differences Exchanges between the Notifier and the Competent Authorities Part 3 - The Requirements - The Dossier New requirements: for which substances? for which products? Bringing an existing dossier into line with the new regulatory obligations Part 4 - Case studies Part 5 - Q&A I Assessment of acquired skills through a final quiz Methodology used The training is delivered through a presentation containing case studies, role plays and continuous interaction with the expert. The support will be given to the trainees. A final quiz will validate the acquired knowledge. For better online learning, our training courses are held in small groups of a minimum of three people up to a maximum capacity of 6 people. Our courses are delivered through synchronous learning. Public Public Regulatory Affairs Officer responsible for products/active substances. Prerequisites Scientific background. Beginner in regulatory affairs for plant protection products. Chat Chat 7 Hours Location Chat From 580€ Contact us Online French session Estelle Beltran Head of Plant Protection Parole de client « I will recommend it to my close colleagues. » La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. A propos de CEHTRA Nous sommes spécialisés depuis 20 ans dans l’accompagnement des entreprises pour la mise sur le marché de substances ou produits chimiques en France et également en Europe, et hors Europe. Nos toxicologues, écotoxicologues, chimistes mettent à votre disposition leur expertise pour assurer la conformité réglementaire de vos produits. Avec une équipe de 70 personnes, nous couvrons une dizaine de secteurs dont REACH, les biocides, les produits phytosanitaires… +

I Better understand why studies are carried out, what the results mean and how they can be used for Classification & Labelling and Risk Assessment Be able to spot study pitfalls and know how to avoid them Regulatory Ecotoxicology: From appropriate study conduct to environmental risk assessment Discover Regulatory Ecotoxicology: From appropriate study conduct to environmental risk assessment The basics > Ancre 1 Training > Overview Objectives I Skills and Abilities Better understand why studies are carried out, what the results mean and how they can be used for Classification & Labelling and Risk Assessment Be able to spot study pitfalls and know how to avoid them Program Part 1 - Environmental data Reminder of useful physico-chemical parameters Abiotic degradation studies Biotic degradation studies Part 2 - Ecotoxicology Organisms used in regulatory ecotoxicology Ecotoxicology studies: methods Principle of the studies: critical parameters Alternative non-experimental methods used in ecotoxicology Part 3 - Regulatory use of data PBT, POP assessment Risk assessment: Principle and derivation of PNEC from ecotoxicology studies Classification SDS Part 4 - Q&A I Evaluation of knowledge through a final quiz Methodology used The training is delivered through a presentation containing case studies, role plays and continuous interaction with the expert. The support will be given to the trainees. A final quiz will validate the acquired knowledge. For better online learning, our training courses are held in small groups of a minimum of three people up to a maximum capacity of 6 people. Our courses are delivered through synchronous learning. Public Public Scientists and Regulatory Affairs Officers. Prerequisites Bac +2. Chat Chat 10.5 Hours Location Chat From 870€ Contact us Online French session Blandine Journel Expert Ecotoxicologist Parole de client « The training was very comprehensive and understandable, including concrete cases to illustrate the concepts discussed. I now have a global vision of the existing ecotoxicological tests and have more insight on the type of tests to be conducted according to the ingredient to be tested. » La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. A propos de CEHTRA Nous sommes spécialisés depuis 20 ans dans l’accompagnement des entreprises pour la mise sur le marché de substances ou produits chimiques en France et également en Europe, et hors Europe. Nos toxicologues, écotoxicologues, chimistes mettent à votre disposition leur expertise pour assurer la conformité réglementaire de vos produits. Avec une équipe de 70 personnes, nous couvrons une dizaine de secteurs dont REACH, les biocides, les produits phytosanitaires… +

I How to navigate and enter data in IUCLID Be familiar with the main non-technical sections of a REACH dossier and know how to complete them Be able to proofread the technical sections of a REACH dossier Know how to use the various features of IUCLID (exports, validation wizards) Be able to submit a dossier in REACH IT Master IUCLID and register your substances under REACH En savoir plus Training > Master IUCLID and register your substances under REACH The basics > Ancre 1 Overview 3h30 Online French from 345€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities How to navigate and enter data in IUCLID Be familiar with the main non-technical sections of a REACH dossier and know how to complete them Be able to proofread the technical sections of a REACH dossier Know how to use the various features of IUCLID (exports, validation wizards) Be able to submit a dossier in REACH IT Program Part 1 - Introduction to IUCLID 6 Part 2 - Preparing an IUCLID file: company-specific sections, technical sections, Chesar-IUCLID interaction Part 3 - Validation Wizard and plug-ins? IUCLID Part 4 - Dossier creation and submission on REACH IT Part 5 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience Any user of IUCLID 6 to prepare and/or submit REACH dossiers. Prerequisites Access to IUCLID. Be familiar with the REACH regulation and its requirements. Request for information Download the catalogue. Download Trainer Nathalie Mayer Toxicologist About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Addressing the stages of an application for authorisation of a family of biocidal products : - Similarity of composition & grouping of co-formulants - Similarity of uses - Similar level of risk and efficacy Addressing the various points to be taken into account when dividing biocidal product families for current evaluations How do Biocidal Product Families work? Accelerate your time to market! En savoir plus Training > How do Biocidal Product Families work? Accelerate your time to market! The basics > Ancre 1 Overview 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities Addressing the stages of an application for authorisation of a family of biocidal products : - Similarity of composition & grouping of co-formulants - Similarity of uses - Similar level of risk and efficacy Addressing the various points to be taken into account when dividing biocidal product families for current evaluations Program Partie 1 - Evaluation de la similarité - Assessment of similarity : - Similarité de la composition et regroupement des coformulants - Similarité des utilisations - Similitude du niveau de risque et d'efficacité Partie 2 - Division des familles de produits biocides pour les évaluations en cours - Splitting of families for on-going applications Partie 3 - 'Best practices' pour les reunions de pré-soumission - Best practices for pre-submission meeting Partie 4 - Evaluation des acquis au travers d'un quizz final Methods used The course is based on a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience Anyone concerned by the regulations governing biocidal products. Prerequisites Review the GMP guide before the training course (CA-July19-Doc.4.2-Final -Guidance note on GMP concept_rev2). Request for information Download the catalogue. Download Trainer Nathalie Hanon Head of Biocides About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

Latest News Welcome to our corporate news page! Here, you can stay up-to-date with the latest news, innovations, and achievements of our company. From product launches and industry insights to events and company culture, we strive to keep you informed on all aspects of our business. Check back often for fresh updates and exciting news! For more updates and announcements, please follow us on LinkedIn Follow us on Linkedin Join us for a free webinar led by Cyril Cabanes from CEHTRA. Gain insights into the latest regulatory updates and vigilance measures concerning the Urban Waste Water Treatment Directive. April 02th, 2025 Learn about CEHTRA's regulatory intelligence and specialized toxicology services in an exclusive interview. Discover how their expertise spans various sectors and integrates regulatory insights. Join us at Rentrée du DM 2022 on Oct 10 & 11 to explore CEHTRA's comprehensive offerings. July 20th, 2023 Join CEHTRA's QuAC Task Force for PT1 and PT2 dossiers, a practical and cost-efficient solution. Benefit from our expertise in the Biocides sector. Contact Sandra Martinez Bosch ( sandra.martinez.bosch@cehtra.com ) for details and to join now! July 13th, 2023 European Commission's REACH Committee has approved a proposal to restrict the use of microplastics. The proposal is now under review by the European Parliament and Council. If you're unsure about the impact on your business, our experts can assist with regulatory challenges. Contact Stéphane PIERRE at stephane.pierre@cehtra.com . July 11th, 2023 Estelle Beltran introduces our expertise in the plant protection sector. If you have any questions, feel free to contact us at estelle.beltran@cehtra.com . July 6th, 2023

I Understand the obligations under REACH and the impact/penalties in the event of non-compliance Know how to draw up an extended safety data sheet As a downstream user, know how to check your own compliance with supplier SDSs Be familiar with the methods for ensuring compliance in the event of discrepancies between downstream uses and the exposure scenarios covered by the eSDS Familiarise yourself with eSDS: obligations, content and compliance En savoir plus Training > Familiarise yourself with eSDS: obligations, content and compliance The basics > Ancre 1 Overview 29.04.25 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? 21.10.25 Register Objectives I Skills and Abilities Understand the obligations under REACH and the impact/penalties in the event of non-compliance Know how to draw up an extended safety data sheet As a downstream user, know how to check your own compliance with supplier SDSs Be familiar with the methods for ensuring compliance in the event of discrepancies between downstream uses and the exposure scenarios covered by the eSDS Program Part 1 - Actors in the supply chain Part 2 - Obligation of eSDS producers under REACH Part 3 - Key stages in the construction of the CSA/CSR Part 4 - Construction of an extended safety data sheet Part 5 - Stages on receipt of a supplier SDS: compliance objective Part 6 - Impacts/sanctions in the event of non-compliance Part 7 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience People working under the REACH Regulation: - QHSE - manufacturers, formulators, chemical product manufacturers Prerequisites Notions on REACH regulations. Notions on SDS (sections 1-16). Request for information Download the catalogue. Download Trainer Anna Chelle Expologist and regulatory toxicologist About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

CEHTRA stands for Consultancy for Environmental & Human Toxicology and Risk Assessment. Since 2001, we provide high quality scientific and innovative solutions ensuring regulatory compliance of chemicals to international obligations (Biocides, Cosmetics, Plant Protection, Reach,...). Your Specialties, Our Expertise CEHTRA (Consultancy for Environmental & Human Toxicology and Risk Assessment) is a company of social and solidarity economy (entreprise de l’économie sociale et solidaire), the French leader and number 3 worldwide in technical assistance and regulatory, toxicological and ecotoxicological consulting for the sectors related to the chemicals industry. Our ambition: To promote biodiversity by meeting the strategic challenges of our clients. CEHTRA is part of the H2B Group , specialized in testing, inspection and certification related to health and environment issues, on a human scale and with a strategic objective of digital transition. Our headquarters are located near Bordeaux and is present in Europe and worldwide with agencies in France (Bordeaux, Lyon, Paris), Germany, Belgium, Spain, United Kingdom, Canada and India. Key Business Sectors Biocides Chemicals (REACH) Cosmetics Global Chemicals Notification Industrial Hygiene Medical Devices Packaging Pharmaceuticals Plant Protection REACH Authorisation Additional Services Dedicated Support (Régie) Endocrine Disruption Simply Predict Representative S ervices Trainings Digital Tools Part of Our Group Our project « Chèque transformation Numérique » has received a grant from the European Union under the FEDER-FSE Aquitaine 2014-2020 operational program. CEHTRA has received a grant co-funded by Comunidad de Madrid and European Union to boost hiring young talents (Impulso a la contratación en Prácticas de Jóvenes para la Recuperación Económica)

I Areas: food contact, cosmetics and pharmaceuticals Understand the regulatory prerequisites for cosmetic, food contact and pharmaceutical packaging Acquire an overview of the regulatory texts applicable to materials Be familiar with the essential requirements and specific features of this legislation Understand a container/content risk assessment (LMS) Introduction to packaging regulations: understanding and implementing them En savoir plus Training > Introduction to packaging regulations: understanding and implementing them The basics > Ancre 1 Overview 10.06.25 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? 16.09.25 Register Objectives I Skills and Abilities Areas: food contact, cosmetics and pharmaceuticals Understand the regulatory prerequisites for cosmetic, food contact and pharmaceutical packaging Acquire an overview of the regulatory texts applicable to materials Be familiar with the essential requirements and specific features of this legislation Understand a container/content risk assessment (LMS) Program Part 1 - Regulatory requirements for cosmetic packaging Part 2 - Regulatory requirements for food contact packaging Part 3 - Migration principles (container-content interactions) Part 4 - Regulatory requirements for pharmaceutical packaging Part 5 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience Regulatory, Technical and Quality positions. Prerequisites None. Request for information Download the catalogue. Download Trainer Caroline Optiz Head of Packaging About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I How to navigate and enter data in IUCLID Know the main non-technical sections for a REACH dossier and how to fill them in Be able to review the technical sections of a REACH dossier Know how to use the different functionalities of IUCLID (exports, validation wizards) Know how to submit a dossier in REACH IT Master IUCLID and register your substances under REACH Discover Master IUCLID and register your substances under REACH The basics > Ancre 1 Training > Overview Objectives I Skills and Abilities How to navigate and enter data in IUCLID Know the main non-technical sections for a REACH dossier and how to fill them in Be able to review the technical sections of a REACH dossier Know how to use the different functionalities of IUCLID (exports, validation wizards) Know how to submit a dossier in REACH IT Program Part 1 - Introduction to IUCLID 6.5 Part 2 - Preparing an IUCLID file: company specific section, technical sections, Chesar-IUCLID interaction Part 3 - Validation Wizard and plug-ins? IUCLID Part 4 - Dossier creation and submission on REACH IT Part 5 - Q&A I Assessment of acquired skills through a final quiz Methodology used The training is delivered through a presentation containing case studies, role plays and continuous interaction with the expert. The support will be given to the trainees. A final quiz will validate the acquired knowledge. For better online learning, our training courses are held in small groups of a minimum of three people up to a maximum capacity of 6 people. Our courses are delivered through synchronous learning. Public Public Any user of IUCLID 6 to prepare and/or submit REACH dossiers. Prerequisites Know the REACH regulation and its requirements. Chat Chat 3.5 Hours Location Chat From 290€ Contact us Online French session Nathalie Mayer Toxicologist Parole de client « I am very satisfied with this course, which was well adapted to my background and met my needs. Furthermore, the distance learning format is entirely satisfactory, and the limited number of trainees facilitates exchanges. » La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. A propos de CEHTRA Nous sommes spécialisés depuis 20 ans dans l’accompagnement des entreprises pour la mise sur le marché de substances ou produits chimiques en France et également en Europe, et hors Europe. Nos toxicologues, écotoxicologues, chimistes mettent à votre disposition leur expertise pour assurer la conformité réglementaire de vos produits. Avec une équipe de 70 personnes, nous couvrons une dizaine de secteurs dont REACH, les biocides, les produits phytosanitaires… +

I Understand the methodology for the toxicological assessment of medical device components in accordance with ISO 10993-17:2023. New ISO 10993-17 : 2023 - General and new features En savoir plus Training > New ISO 10993-17 : 2023 - General and new features The basics > Ancre 1 Overview 29.09.25 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities Understand the methodology for the toxicological assessment of medical device components in accordance with ISO 10993-17:2023. Program ISO 10993-17, BACKGROUND AND CONTEXT OF THE UPDATE Part 1 - Introduction Scope (releasables, raw materials, degradation products, risks covered) Links with other ISO 10993 standards (-1, -18, -9 etc.) - When is it useful and/or essential? ISO 10993-17 (2002) VS ISO 10993-17 (2023) : A NEW APPROACH Part 2 - What's new New terms, definitions and concepts New approaches: taking into account time periods; adapting exposure by weight (previously tolerable intake by weight). Part 3 - Data generation Characterisation according to ISO 10993-18 - Reminder and pre-test considerations AET - (Analytical Evaluation Treshold) - Importance of validating the method Types of data sought for the TRA. Part 4 - Toxicological Risk Assessment Toxicological Screening Limit (TSL) Exposure (EEDmax) Tolerable intake or contact (TI, TIcancer, TCL) Calculation of MOS Part 5 - Conclusion: Endpoint to be assessed Part 6 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based around a presentation containing case studies and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience DM players responsible for toxicological risk analysis and biocompatibility assessment, quality managers, functions responsible for compiling technical documentation. Prerequisites General knowledge of issues relating to the biocompatibility of healthcare products, in particular ISO standards 10993-18, -12 and -1. As this is not initial training, knowledge of the previous version of ISO 10993-17: 2002 and basic toxicology concepts is very important (threshold value, exposure dose, systemic vs. local toxicity, NOAEL/LOAEL, etc.). Request for information Download the catalogue. Download Trainer Paul Fernandes Biocompatibility toxicologist About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Understand the role of toxicology in the life of substances in accordance with regulations Understanding the main tests, their difficulties and the issues involved Optimising interaction between managers and experts Toxicology and Classification - the fundamentals of your regulatory success En savoir plus Training > Toxicology and Classification - the fundamentals of your regulatory success The basics > Ancre 1 Overview 12.06.25 to 13.06.25 14 hours Online French from 1380€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities Understand the role of toxicology in the life of substances in accordance with regulations Understanding the main tests, their difficulties and the issues involved Optimising interaction between managers and experts Program Part 1 - Regulatory toxicology ? General information Part 2 - ADME (Absorption, Distribution, Metabolism, Excretion): concepts Part 3 - Acute systemic toxicology (oral, cutaneous, inhalation) Part 4 - Local skin and eye tolerance Part 5 - Skin sensitisation Part 6 - Repeated-dose and chronic toxicity Part 7 - Reproductive and developmental toxicity Part 8 - Mutagenicity and genotoxicity - Classification Part 9 - Carcinogenesis Part 10 - Introduction to non-experimental alternative methods used in toxicology Part 11 - Introduction to the determination of Toxicological Reference Values Part 12 - Introduction to human health risk assessment Part 13 - Assessment of knowledge through a final quiz Methods used The course is based around an interactive presentation with ongoing engagement between the trainees and the expert. Trainees will be provided with the course materials. A final quiz will validate the knowledge acquired. To enhance e-learning, our courses are run in small groups, ranging from a minimum of three people to a maximum of six. Our courses are delivered through synchronous learning. Public Audience Employees involved in product safety. Prerequisites None. Request for information Download the catalogue. Download Trainer Nathalie Mayer Toxicologist 2024 « Formation très complète, très claire et très utile. Formatrices très professionnelles. » About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Understanding regulatory procedures for active substances and products Understanding zonal assessment and dRR dossiers Understanding the content of dossiers and the pitfalls to avoid Plant Protection Products: from regulation to registration En savoir plus Training > Plant Protection Products: from regulation to registration The basics > Ancre 1 Overview 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities Understanding regulatory procedures for active substances and products Understanding zonal assessment and dRR dossiers Understanding the content of dossiers and the pitfalls to avoid Program Part 1 - Regulation (EC) No 1107/2009 The main points The different procedures involved Part 2 - Zonal assessment Zonal assessment: North, Centre and South zones: similarities and differences Exchanges between the Notifier and the Competent Authorities Part 3 - Requirements - The Dossier New requirements: for which substances? for which products? Bringing an existing dossier into line with the new regulatory requirements Part 4 - Case studies Part 5 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience Regulatory Affairs Officer in charge of Products/Active Substances. Prerequisites Scientific background. Beginner in regulatory affairs for plant protection products. Request for information Download the catalogue. Download Trainer Estelle Beltran Head of Plant Protection Products About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

Our DNA is international. You can find contact details of all our offices on this page. Our DNA is international Click on the country below for more details North America Europe Asia Canada France Germany Spain India United Kingdom Canada 24 Ivy Lea Crescent Toronto ON M8Y 2B6 Phone: +1 (416) 432-4020 France 126 rue du Landy 93400 Saint-Ouen 15 rue Aristide Briand 33150 Cenon, Bordeaux Phone: +33 (0) 557 77 56 10 8 avenue Leclerc 69007 Lyon Contact - France Germany CEHTRA GmbH Christoph-Probst-Weg 4 20251 Hamburg Phone: +49 ( 0)40 611 35 455 Contact - Germany India CEHTRA Chemical Consultants Pvt. Ltd. B1/A5, Mohan Co-Operative Industrial Estate, New Delhi-110044, INDIA Contact - India Spain Calle Pintor Murillo 29 – oficina bajo A 28100 Alcobendas Madrid Phone: +34 918 429 142 Contact - Spain United Kingdom CEHTRA Limited, Suite 31, 1 Hanley Street, Nottingham NG1 5BL United Kingdom Contact - United Kingdom

I Knowing and understanding Cosmetics Regulation 1223/2009 Understand the risk assessment of a cosmetic product Identify areas for improvement in order to comply with regulatory obligations Safer cosmetics for tomorrow - Know your regulatory obligations En savoir plus Training > Safer cosmetics for tomorrow - Know your regulatory obligations The basics > Ancre 1 Overview Coming soon 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities Knowing and understanding Cosmetics Regulation 1223/2009 Understand the risk assessment of a cosmetic product Identify areas for improvement in order to comply with regulatory obligations Program Part 1 - Regulatory context for cosmetic products (Europe and other countries) European Cosmetics Regulation n° 1223/2009 - Scope / Borderline products - Cosmetovigilance - Management of updates Part 2 - Cosmetic product safety report - Notion of safety assessment: MoS calculation, local tolerance, etc. - Toxicological profiles of ingredients Part 3 - Specific cases - Baby products, perfumes - In silico Part 4 - Q&A I Assessment of knowledge acquired through a final quiz Methods used The course is based on a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience R&D, Regulatory, Quality, Safety Assessors, Manufacturers, Distributors, Subcontractors, Suppliers, Importers. Prerequisites Cosmetics regulatory affairs officer or toxicologist. Request for information Download the catalogue. Download Trainer Clarisse Bavoux Head of Cosmetics About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

Regular training is essential to keep up-to-date with the changing regulations.You choose what you want to learn and when. You can come to us or we can come to you. CEHTRA Training Deepen your knowledge with our expertise. Find the right course for you among our programmes. Discover Nos programmes Our programmes Regular training is essential to keep abreast of regulatory changes. Choose the formula that suits your needs. THE BASICS Learn and keep up to date on the essentials of the regulations. Discover MENTORING Tailor-made training to meet the specific challenges of your company. Discover All our courses can be adapted for people with disabilities. What our customers say "I am very satisfied with this course, which was well adapted to my background and met my needs. Furthermore, the distance learning format is entirely satisfactory, and the limited number of trainees facilitates exchanges." La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. See our certificate About CEHTRA We have been specialising for 20 years in assisting companies in the marketing of chemical substances or products in France and also in Europe and outside Europe. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover a dozen sectors including REACH, biocides, plant protection products, etc... +

ED Pedia allows any stakeholder of a substance to check instantaneously whether this substance likely has, or not, ED properties and to access instantaneously to the relevant documentation. It also allows to download a PDF report on the findings and if needed, to access CEHTRA expert advice to draw conclusions from the report. How likely is it for my substance to be an Endocrine Disruptor ? Enter the CAS number >> Get results >> Download report Try it now! What is ED Pedia? ED Pedia allows any stakeholder of a substance (a) to check instantaneously whether this substance likely has, or not, ED properties, (b) to access instantaneously to the relevant documentation, (c) to download a PDF report on the findings and ( d) if needed, to access CEHTRA expert advice to draw conclusions from the report. Access ED Pedia What is an Endocrine Disruptor? According to the WHO definition 2002, an Endocrine Disruptor (ED) is 'an exogenous substance or mixture that alters function(s) of the endocrine system and consequently causes adverse effects in an intact organism, or its progeny, or (sub)populations'. This definition is used to identify Substances of Very High Concern (“SVHC ”) for human health and/or the environment due to their endocrine disrupting properties under the REACh (Registration, Evaluation, Authorization and restriction of Chemicals) legislation (European Parliament and Council of the European Union, 2006). A definition of endocrine disruptors for substances in plant protection and biocidal products was adopted in 2017 at European level (EU Regulations 2017/2100 and 2018/605 ) (European Commission, 2017, 2018). In 2018, a guidance document was published by the European Food Safety Authority (EFSA) for the identification of endocrine disruptors (EFSA, 2018). Several other agencies and public programs also focus on this issue. How does ED Pedia work? ED Pedia searches for CAS Numbers in lists yield from hazard assessment programs that identify potential Endocrine Disruptors, with different levels of concern. For a specific Substance CAS Number, ED Pedia reports for each of the lists whether or not the substance is included. Results, especially those describing the outcome of ED evaluation by the relevant authorities should be taken with care, as CEHTRA – though delivering its best efforts - is not responsible and shall not be held liable for the content of the lists. Media Videos Flyers Useful information for ED Pedia users Terms of use | Legal | Data privacy What is an ED?

I Know the obligations under REACH Know how to use CHESAR to perform a CSA (Chemical Safety Assessment) Know how to generate a CSR (Chemical Safety Report) under CHESAR To be in compliance with ECHA expectations Master CHESAR to simplify your REACH evaluations Discover Master CHESAR to simplify your REACH evaluations The basics > Ancre 1 Training > Overview Objectives I Skills and Abilities Know the obligations under REACH Know how to use CHESAR to perform a CSA (Chemical Safety Assessment) Know how to generate a CSR (Chemical Safety Report) under CHESAR To be in compliance with ECHA expectations Program Part 1 - Obligation under REACH towards CSR Part 2 - Definition and construction steps of the CSA Part 3 - Occupational risk assessment Part 4 - Consumer risk assessment Part 5 - Environmental risk assessment Part 6 - Creation of the full CSR and compliance with ECHA controls Part 7 - Q&A I Assessment of competence acquisition through a final quiz Methodology used The training is delivered through a presentation containing case studies, role plays and continuous interaction with the expert. The support will be given to the trainees. A final quiz will validate the acquired knowledge. For better online learning, our training courses are held in small groups of a minimum of three people up to a maximum capacity of 6 people. Our courses are delivered through synchronous learning. Public Public People working in the framework of the REACH Regulation: - Regulatory Affairs Officer - Toxicologist - Ecotoxicologist - QHSE Prerequisites Notions on the REACH Regulation. Chat Chat 7 Hours Location Chat From 580€ Contact us Online French session Anna Chelle Expologist and regulatory toxicologist Parole de client « Very good. Very useful information. I will use the slides in my daily work. Anna was very clear and answered our questions. She also adapted to our needs and focused on the most relevant points for us. Many thanks. » La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. A propos de CEHTRA Nous sommes spécialisés depuis 20 ans dans l’accompagnement des entreprises pour la mise sur le marché de substances ou produits chimiques en France et également en Europe, et hors Europe. Nos toxicologues, écotoxicologues, chimistes mettent à votre disposition leur expertise pour assurer la conformité réglementaire de vos produits. Avec une équipe de 70 personnes, nous couvrons une dizaine de secteurs dont REACH, les biocides, les produits phytosanitaires… +

I Understand the obligations under REACH How to use CHESAR to carry out a CSA (Chemical Safety Assessment) Be able to generate a CSR (Chemical Safety Report) under CHESAR Comply with ECHA expectations Master CHESAR to simplify your REACH assessments En savoir plus Training > Master CHESAR to simplify your REACH assessments The basics > Ancre 1 Overview 02.04.25 to 03.04.25 10h30 hours Online French from 1035€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? 07.10.2025 to 08.10.25 Register Objectives I Skills and Abilities Understand the obligations under REACH How to use CHESAR to carry out a CSA (Chemical Safety Assessment) Be able to generate a CSR (Chemical Safety Report) under CHESAR Comply with ECHA expectations Program Part 1 - Obligations under REACH with regard to CSR Part 2 - Definition and construction stages of the CSA Part 3 - Occupational risk assessment Part 4 - Consumer risk assessment Part 5 - Environmental risk assessment Part 6 - Creation of the complete CSR and compliance with ECHA controls Part 7 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will be given the course material. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience People working on REACH regulations: - Regulatory affairs officer - Toxicologist - Ecotoxicologist - QHSE Prerequisites Notions on REACH regulations. Request for information Download the catalogue. Download Trainer Anna Chelle Expologist and regulatory toxicologist About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Understand the place of toxicology in the life of substances according to the regulations Knowing the main tests, their difficulties, their stakes Optimise the interaction between managers and experts Toxicology and Classification - the fundamentals of your regulatory success Discover Toxicology and Classification - the fundamentals of your regulatory success The basics > Ancre 1 Training > Overview Objectives I Skills and Abilities Understand the place of toxicology in the life of substances according to the regulations Knowing the main tests, their difficulties, their stakes Optimise the interaction between managers and experts Program Part 1 - Regulatory Toxicology ? General Part 2 - ADME (Absorption, Distribution, Metabolism, Excretion): concepts Part 3 - Acute systemic toxicology (oral, dermal, inhalation) Part 4 - Local skin and eye tolerance Part 5 - Skin Sensitisation Part 6 - Repeat and Chronic Toxicity Part 7 - Reproductive and Developmental Toxicity Part 8 - Mutagenicity and Genotoxicity - Classification Part 9 - Carcinogenesis Part 10 - Introduction to alternative non-experimental methods used in toxicology Part 11 - Introduction to the determination of Toxicological Reference Values Part 12 - Introduction to Human Health Risk Assessment Part 13 - Toxicology described through a regulatory dossier (REACH) - case study Part 14 - Assessment of learning through a final quiz Methodology used The training is delivered through a presentation containing case studies, role plays and continuous interaction with the expert. The support will be given to the trainees. A final quiz will validate the acquired knowledge. For better online learning, our training courses are held in small groups of a minimum of three people up to a maximum capacity of 6 people. Our courses are delivered through synchronous learning. Public Public Employees involved in product safety. Prerequisites None. Chat Chat 14 hours Location Chat From 1160€ Contact us Online French session Nathalie Mayer Toxicologist Parole de client « I am very satisfied with this training course which is well adapted to my background and which met my needs. Furthermore, the distance learning format is entirely satisfactory, and the limited number of trainees facilitates exchanges. » La certification qualité a été délivrée au titre de la catégorie d’action suivante : ACTION DE FORMATION. A propos de CEHTRA Nous sommes spécialisés depuis 20 ans dans l’accompagnement des entreprises pour la mise sur le marché de substances ou produits chimiques en France et également en Europe, et hors Europe. Nos toxicologues, écotoxicologues, chimistes mettent à votre disposition leur expertise pour assurer la conformité réglementaire de vos produits. Avec une équipe de 70 personnes, nous couvrons une dizaine de secteurs dont REACH, les biocides, les produits phytosanitaires… +

I Gain a better understanding of why studies are carried out, what the results mean and how they can be used for Classification and Risk Assessment. Be able to spot the pitfalls of studies and know how to avoid them Regulatory ecotoxicology: from the appropriate conduct of studies to environmental risk assessment En savoir plus Training > Regulatory ecotoxicology: from the appropriate conduct of studies to environmental risk assessment The basics > Ancre 1 Overview 06.10.25 to 07.10.25 10h30 Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities Gain a better understanding of why studies are carried out, what the results mean and how they can be used for Classification and Risk Assessment. Be able to spot the pitfalls of studies and know how to avoid them Program Part 1 – Environmental data Review of useful physico-chemical parameters Study of abiotic degradation Study of biotic degradation Bioaccumulation Part 2 – Ecotoxicity Organisms used in regulatory ecotoxicology Ecotoxicity studies: methods Study principles: critical parameters Non-experimental alternative methods used in ecotoxicology Part 3 – Regulatory use of data PBT, POP, PMT evaluation Risk assessment: Principle and Derivation of PNECs from ecotoxicity studies Classification SDS (Safety Data Sheets) Part 4 – Q&A | Knowledge assessment through a final quiz Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. English-language support material will be provided to trainees. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience Scientists and Regulatory Affairs Managers. Prerequisites Bac +2. Request for information Download the catalogue. Download Trainer Blandine Journel Senior Ecotoxicologist About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Understand the methodology of biological assessment in accordance with EN ISO 10993-1 Assess the conformity of a biological assessment plan Biological evaluation of medical devices in accordance with EN ISO 10993-1 En savoir plus Training > Biological evaluation of medical devices in accordance with EN ISO 10993-1 The basics > Ancre 1 Overview 22.09.25 7 hours Online French from 690€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? Register Objectives I Skills and Abilities Understand the methodology of biological assessment in accordance with EN ISO 10993-1 Assess the conformity of a biological assessment plan Program Part 1 - Context of the standard in European regulations Part 2 - The fundamental principles of the ISO 10993 series Part 3 - Biological assessment using the methodology of EN ISO 10993-1 Part 4 - Case study to conclude on the conformity of the proposed biological assessment plan Part 5 - Evaluation by questionnaire Methods used The course is based around a presentation containing case studies, role-playing exercises and ongoing interaction with the expert. Trainees will receive a handout. A final quiz will validate what has been learnt. To enhance online learning, our courses are run in small groups, from a minimum of three people to a maximum of 6. Our courses are delivered through synchronous learning. Public Audience DM players. Quality managers. Functions responsible for compiling technical documentation. Prerequisites Knowledge of medical device risk classes, the EU certification process as presented in Regulation 2017/745. General knowledge of issues relating to the biocompatibility of healthcare products. Request for information Download the catalogue. Download Trainer Paul Fernandes Biocompatibility toxicologist About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

I Be able to describe the basics of European regulation 2022/1616/EC for recycled plastics in contact with foodstuffs Be able to describe the basics of US regulations for recycled plastics: No Objection Letters, processes, etc. Regulations in Europe and the USA for recycled plastics intended for contact with food and in cosmetics En savoir plus Training > Regulations in Europe and the USA for recycled plastics intended for contact with food and in cosmetics The basics > Ancre 1 Overview 17.06.25 1h30 Online French from 148€ (HT) 2 months Lieu Dates Price Duration Language Access time Would you like to register? 29.09.25 Register Objectives I Skills and Abilities Be able to describe the basics of European regulation 2022/1616/EC for recycled plastics in contact with foodstuffs Be able to describe the basics of US regulations for recycled plastics: No Objection Letters, processes, etc. Program Part 1 - Regulation 2022/1616/EC - Recycled plastic articles Part 2 - FDA - No Objection Letter (NOL) - recycled plastic articles Part 3 - Q&A I Assessment of skills acquired through a final quiz Methods used The course is based on a presentation with role-playing exercises and ongoing interaction with the expert. The support material will be given to the trainees. A final quiz will validate what has been learnt. To enhance e-learning, our courses are run in small groups, from a minimum of three people to a maximum of 8. Our courses are delivered through synchronous learning. Public Audience Players in the food and cosmetics packaging industry. Prerequisites None. Request for information Download the catalogue. Download Trainer Caroline Optiz Head of Packaging About CEHTRA For 20 years we have specialised in assisting companies with the marketing of chemical substances and products in France, Europe and beyond. Our toxicologists, ecotoxicologists and chemists provide you with their expertise to ensure the regulatory compliance of your products. With a team of 70 people, we cover around ten sectors, including REACH, biocides, plant protection products, etc. +

CEHTRA is an international leader in technical and regulatory support with regard to the safety of chemical products. Our focus is on scientific and innovative solutions ensuring regulatory compliance of chemicals to international obligations: from portfolio strategy to notification of chemicals and OUR EXPERTISE Biocides Are you required to renew an approval of an active substance, to submit a product authorisation or BPF dossier, to apply for Article 95 List inclusion or for Technical Equivalence? Chemicals (REACH) A solid, highly experienced team focussed on helping you meet your compliance deadline. Cosmetics Demonstrate the safety of both your finished products and ingredients. Get the packaging safety tested. Shorten the time to market. Global Chemicals Notification Our internal tools designed to provide you the best worldwide, personalized and optimized strategy for a minimum cost. Industrial Hygiene CEHTRA's industrial hygienists have decades of experience working with clients in their industrial sites and manage Environmental, Health and Safety challenges with a well balanced mix of technical expertise and practical experience. Packaging Experienced, quality support in managing complex and constantly evolving regulation on packaging. Pharmaceuticals For the safety of your pharmaceutical substances & products we can assist you in the development of your new drugs, safety of your drug production and generation of environmental risk assessment. Plant Protection As a manufacturer or a distributor in the field of agriculture, you want to get your substances approved efficiently and get your Plant Protection Products on the market. REACH Authorisation REACH Authorisation is an European risk management measure which aims to limit human and environmental exposure to substances considered of very high concern.

CEHTRA assists you in updating your REACH registration dossiers. CEHTRA advises you for your chemical products: IUCLID studies, only representative (OR), advice on a substance, fragrance (UVBC), joint submission or consortium and data cost sharing. Top of the page CHEMICALS (REACH) Description Contact Key Services REACH dossier Value-added Trainings Media A solid, highly experienced team focused on helping you meet your compliance deadline. You're in safe hands. A solid REACH dossier will enable you to put your substance on the market serenely. Your product is your priority, you are ours. During REACH Phase 1, 2 & 3 CEHTRA provided high quality technical and regulatory support and obtained extensive experience which can be a real asset to industry faced with the challenge of managing, completing and updating dossiers. Moreover, by implementing Regulation (EU) 2020/1435 of 9 October 2020, the European Commission has now clarified when companies need to update their REACH registration dossiers. Click here to read more about how CEHTRA experts can assist you with REACH registration dossier updates. Description Contact Meet our experts Mathieu ROLLAND Head of REACH mathieu.rolland@cehtra.com Brigitte CASENAVE Senior Chemist brigitte.casenave@cehtra.com Key Services Key Services Dossier compilation & update Lead registrant and co -registrant dossiers testing strategy SIEF Management Only Representative Supply-chain management Consortium and SIEF communication, administrative and financial management of LoA Representation of non-EU companies through our Only-Representative (OR) Legal Entity and UK-REACH Obligations as EU importer, manufacturer or Downstream-User (DU) Notifications to ECHA CEHTRA's consultants have been involved in the preparation of hundreds of REACH registration dossiers, acting on behalf of either the Lead Registrant or a coregistrant. Industrials have successfully experienced CEHTRA and they continue for reviewing their product portfolio and strategy for REACH registration of substances, adapting testing strategies, expert regulatory and scientific advices. REACH dossier registration updates Implementing Regulation (EU) 2020/1435 of 9 October 2020, the European Commission has now clarified when companies need to update their REACH registration dossiers. The requirement to update ‘without undue delay’ is in most cases specified as three months and, in more complex cases, up to 12 months. Additionally, Cefic, through its multi-annual Action Plan, provides a framework for REACH registrants to evaluate the safety data in a stepwise manner. IUCLID Migration Dossier Review Lead Registration dossier update Co-registration dossier update TCC passing for dossiers submitted in older versions of IUCLID 6 Full update for IUCLID 5 dossiers Listing vulnerabilities and corrective actions Expert advice to tackle them Boundary composition including all SIEF information Outcomes associated to new studies CSR with CHESAR New UVCB qualities New impurity profile Impact for C&L Tonnage update We have indeed a large amount of experience in the update process: i) IUCLID Migration Services Only by using the Technical Completeness Check (TCC) tool in the latest version of IUCLID can you ensure your submission will pass the first submission processing steps in REACH IT. Our team has good experience with IUCLID migration services. If you have any questions, write to one of our experts or simply drop your query in the chat window below and one of our experts will get back to you. ii) Joint Submission Services CEHTRA experts accompany: Companies to update their dossier within or without the CEFIC Action Plan Lead Registrants for preparing the dossier updates and derivation of the cost of the Joint Submission and for each co-registrant. Co-registrants when supply-chain and/or composition has been modified. Chemicals (REACH) - Dossier update Value-added Services Trainings Value-added Services Cost-sharing and data-sharing UVCB registration QSARs and others NAMs Expert advice Study monitoring PRIMO tool to optimize management and follow-up of data Trainings 02 Avr 2025 Master CHESAR to simplify your REACH assessments en savoir plus s'inscrire 29 Avr. 2025 Familiarise yourself with eSDS: obligations, content and compliance en savoir plus s'inscrire Master IUCLID and register your substances under REACH en savoir plus s'inscrire Media Related Sectors Global Notifications Industrial Hygiene Simply Predict REACH Authorisation Haut de page

The Brexit transition deadline of 31 December 2020 is fast approaching and it is vital that companies ensure that they remain compliant beyond this date. CEHTRA remains available to answer any queries to ensure you are compliant with the new regulatory framework which will apply from 1 January 2021. Brexit Follwing the UK's departure from the European Union, CEHTRA team remains available to answer any queries you may have to ensure you are compliant with the new regulatory framework which applies from 1st January 2021. We have addressed some key information related to four of key business sectors (REACH, Biocides, Plant Protection and Cosmetics) on this page to keep you informed how CEHTRA experts can accompany you with the new regulatory framework. Key Contacts Biocides Annekathrin FAUPEL Regulatory Affairs Specialist annekathrin.faupel@cehtra.com REACH Plant Protection Melanie HARPER Regulatory Affairs Specialist melanie.harper@cehtra.com Philippe ADRIAN Head of Plant Protection philippe.adrian@cehtra.com REACH UK REACH Registration and OR UK REACH OR Consortium Management Support for negotiation with data holders for access Communications with UK regulatory authorities Biocides Plant Protection Great Britain (England, Scotland and Wales) will establish independent pesticides regulatory rules on 1 January 2021. Therefore please make sure that your current UK products are authorised under the new rules. According to CRD, the new laws to ensure the safe use of plant protection products will be similar to existing laws including compliance with regulations for Maximum Residue Levels (MRLs). Current product authorisations and MRLs will still be valid in the Great Britain from 1 January 2021. The Health and Safety Executive (HSE) will continue to operate as the UK’s regulator. In addition, under the terms of the Northern Ireland Protocol, the EU pesticides rules will continue to apply in Northern Ireland after 1 January 2021. CEHTRA will continue to support its clients for their UK products. REACH UK REACH Registration UK REACH OR Consortium Management Support for negotiation with data holders for access Communications with UK regulatory authorities Biocides UK BPR OR (Article 95) UK BPR Registration UK BPR Authorisation From 1 January 2021, Great Britain (England, Scotland and Wales) will put in place a regulatory framework for biocidal products. It will be similar to EU framework (EU BPR), but both will operate independently of each other. All applications will be submitted to HSE as regulating authority Biocidal product authorizations and active substance approvals that are valid in GB will remain valid until their normal expiry date. The authorization will need to be transferred to a company based in UK. The authorization holder of biocidal actives and products will need to be established in the UK by 1st January 2022. Respective data might have to be resubmitted to HSE. These data will be the same data or other information that you previously submitted to ECHA or other competent authorities. Biocidal product or active substance applications still under evaluation after 31st December 2020 will be continued by HSE where possible to grant the authorization. Information supporting the original application has to be resubmitted for enabling HSE to complete the evaluation within 90 or 180 days depending on your situation. A UK article 95 list for approved a.s. suppliers will be established similar to the EU Article 95 list. To stay on the UK Article 95 list you will have to comply with the according requirements within 2 years’ time. Plant Protection Great Britain (England, Scotland and Wales) will establish independent pesticides regulatory rules on 1 January 2021. Therefore please make sure that your current UK products are authorised under the new rules. According to CRD, the new laws to ensure the safe use of plant protection products will be similar to existing laws including compliance with regulations for Maximum Residue Levels (MRLs). Current product authorisations and MRLs will still be valid in the Great Britain from 1 January 2021. The Health and Safety Executive (HSE) will continue to operate as the UK’s regulator. In addition, under the terms of the Northern Ireland Protocol, the EU pesticides rules will continue to apply in Northern Ireland after 1 January 2021. CEHTRA will continue to support its clients for their UK products. Cosmetic products Great Britain (England, Scotland and Wales) establishes independent regulatory rules for cosmetic products placed on the British market from January 1, 2021. The regulation remains very close to the Cosmetic Regulations (with a PIF, a safety report, a notification). The Responsible Person must be in Great Britain. By default, the importer is this RP. It is recommended to identify a RP who will be able to assume all the responsibilities for the safety of the product. A notification will also have to be made on the UK portal. These steps are valid for new products as well as for existing products entering Great Britain. CEHTRA can assist cosmetics manufacturers in these procedures.

CEHTRA ensures the safety and conformity of your substances and plant protection products. Our experts help you to meet regulatory requirements: approval and authorisation dossiers, data gap analysis, toxicological and environmental risk assessments, and endocrine disrupting (ED) properties. Top of the page Description PLANT PROTECTION Description Contact Key Services Biocontrol Value-added Trainings Media As a manufacturer or a distributor in the field of agriculture, you want to get your substances approved efficiently and get your Plant Protection Products on the market. From Data Gap Analysis through to the dossier submission to the competent authorities, CEHTRA's team supports you in the necessary steps to meet the current regulatory requirements, for a successful registration. Contact Meet our experts Estelle BELTRAN Head of Plant Protection estelle.beltran@cehtra.com Blandine JOURNEL Expert Ecotoxicologist blandine.journel@cehtra.com Key Services Value-added Key Services Regulatory Dossiers From registration strategy up to the post-submission defense Data Gap Analysis Testing proposal Study monitoring Hazard identification Scientific rationale Risk Assessment Toxicology Consumer Environment Ecotox Modelling and refinement Task Force Management Management support to facilitate joint applications in the EU and abroad Value-added Services Endocrine Disrupting Properties CADDY and IUCLID dossiers Biocontrol Diagnostic Fertilizers and Biostimulants Environmental Screening Tailored studies (operator, field) Authorization of formulated products (including North and South America) Trainings Trainings Plant Protection Products: from regulation to registration en savoir plus s'inscrire 06 Oct. 2025 Regulatory ecotoxicology: from the appropriate conduct of studies to environmental risk assessment en savoir plus s'inscrire Media Flyers Media Related Sectors Simply Predict Haut de page

CEHTRA ensures the safety and compliance of your cosmetic products via safety report (CPSR) and product information file (PIF). Our databases anticipate the risks of your products and give you access to numerous toxicological profiles. Our expertise extends to the eco-conceptions of your formula . Top of the page COSMETICS Cosmetick Contact Key Services CPSR Ecotoxicology Value-added Trainings Media Our Tools Check out if toxicological and eco-toxicological profiles for your ingredients of interest are covered in Cosmetick! Search profiles Tools Contact Key contacts Clarisse BAVOUX Head of Cosmetics clarisse.bavoux@cehtra.com Marlène BARON Toxicologist marlene.baron@cehtra.com Key Services Cosmetic products & formulations : safety, ecotoxicology, expert advice and regulatory reports Pre-assessment Cosmetic Product Safety Reports (CPSR) Ingredients, Raw Materials : Toxicity, Ecotoxicity and Maximum Doses Toxicological profiles Ecotoxicological profiles Identification of safe concentrations for cosmetic uses Ingredients under development: strategy, dossier (toxicology and ecotoxicology) Support for toxicological and ecotoxicological issues Testing strategy In silico approach Additional data Final dossier Literature search, bibliography In vitro tests: analysis and advice Management of da ta gaps by alternative methods (Read-Across, in silico approach) Key Services CEHTRA has been commissioned by numerous companies including multi-nationals in the cosmetics industry to assist them with cosmetic regulation compliance. CEHTRA evaluates the safety of several types of products (care, hygiene, perfumes...), and new ingredients. Cosmetick includes comprehensive databases allow us to anticipate risks for your products. We can propose complementary approaches in case of data gaps (structural alerts, QSAR, Read-across). Our eco-toxicologists can contribute to the eco-conceptions of your formula. At CEHTRA, we are professional partner of the Cosmetic Valley and provide different training courses on the Fundamentals of the Cosmetic Regulation, webinars on Content / Container Interactions or seminaire in University. "COSMETICK Advanced is a very useful tool for any cosmetic products safety assessor : all required data are gathered (very complete toxicological profils but also ecotoxicity data and regulation alerts). The tool can be used to assess the systemic risk of products ingredients and impurities. It also provides local tolerance alerts. It is very easy to use and a great help when you start working on a new project." Ecoxotoxicology Services and Tools in Ecotoxicology CEHTRA is committed to the protection of the environment, and offers services and tools in ecotoxicology: COSMETICK is an online software solution offering ecotoxicological profiles and an "Ecotoxicological Alerts" system for ingredients and formulas ECOSCORES can be customised to score and measure the ecotoxicological and environmental footprint of cosmetic products ECOTOXICOLOGICAL EVALUATIONS of ingredients and formulas allow prioritisation of ingredient choices up to the obtaining of Labels such as the EU ECOLABEL (rinsed and non-rinsed cosmetic products) MISSING DATA can be replaced in part by results from alternative methods (Read-Across, in silico approaches) Our ADVICE and REGULATORY support enable us to ensure the compliance of your products and ingredients, manage risks and anticipate regulatory changes. Value-added Services In-depth expertise for INCI, impurities and fragrance components, including MOS and QRA Hazard assessment (toxicology and ecotoxicology) Extensive and cross-cutting areas of expertise: from environment to human health, from formulation to packaging Data qualification Monitoring of studies Cosmetick database (toxicological & ecotoxicological profiles, formula analysis) Trainings 17 Juin 2025 Regulations in Europe and the USA for recycled plastics intended for contact with food and in cosmetics en savoir plus s'inscrire 10 Juin 2025 Introduction to packaging regulations: understanding and implementing them en savoir plus s'inscrire Media Flyers Value-added Services Trainings Media Related Sectors Packaging Simply Predict Our Partners Haut de page