COSMETICK: the digital tool for cosmetic compliance and safety

COSMETICK offers two licence levels designed for professionals involved in cosmetic safety assessment and cosmetic regulatory compliance: BASIC Licence Provides access to the COSMETICKtoxicological database, including structured cosmetic toxicological profiles required for CPSR preparation. ADVANCED Licence Provides full platform access, including the toxicological database, formula evaluation features, automatedMargin of Safety (MOS)calculation, and structured documentation to support CPSR preparation. Each licence is available under two access models: • Unlimited access – suitable for teams conducting regular safety assessments • On-demand access – flexible solution for occasional toxicological evaluations Need guidance selecting the most appropriate solution for your cosmetic risk assessment needs? Contact us at cosmetick@cehtra.com.(mailto:cosmetick@cehtra.com)

If a cosmetic toxicological profile is not available in the COSMETICK toxicological database, you may submit a request directly via the online form. Each request is reviewed by regulatory toxicologists to ensure that the newly developed profile meets scientific and regulatory standards applicable to cosmetic safety assessment and CPSR preparation. Once validated, the profile is added to the toxicological database. You can track the progress of your request online and will receive an email notification when it becomes available.

COSMETICK produces a structured pre-assessment containing the key elements required for preparation of the Cosmetic Product Safety Report (CPSR), in accordance with Annex I of Regulation (EC) No 1223/2009. This pre-assessment includes: • Exposure assessment based on the product formulation • Calculation of the Margin of Safety (MOS) for each ingredient • Evaluation of impurities, including CMR substances (carcinogenic, mutagenic or reprotoxic) • Identification of relevant toxicological warnings • Justification of skin tolerance • Integration of user-specific data (test results, specifications, supplier information) The generated document supports preparation of Part B of the CPSR, which must be reviewed and validated by a qualified safety assessor in accordance with Article 10 of the EU Cosmetic Regulation.