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The evaluation of substances for Endocrine Disruption (ED) potential has been mandatory since 2018 under the Plant Protection Products and Biocide Products regulations.

The year 2023 is a key turning point :

  • the Commission adopted a Delegated Act to introduce new hazard classes under the CLP for endocrine disruptors in December 2022. It is expected to enter into force soon, after scrutiny by the European Parliament and Council.

  • Also, the update of regulation on Cosmetic Products to take into account ED assessment is awaited in the coming months.

  • In addition, the next update of REACH regulation is expected to include new requirements to identify ED from the lowest tonnage band at the end of the year/beginning of next year.

CEHTRA can provide you a balanced and independent ED assessment by experts and can guide you to obtain reliable results using appropriate state-of-the-art tools and methods for your substances of interest.

Key Services

Optimised assessment of ED properties

Generating new data

Data compilation for regulatory dossiers



  • Existing regulatory data

  • Targeted bibliographic search

  • QSAR screening

  • Tailored testing strategies (based on in silico, in vitro and/or in vivo studies)

  • Study monitoring of ED specific studies

  • Robust study summaries

  • EFSA table and identification of lines of evidence

  • Reports on ED assessments of specific ingredients or formulations

  • Position papers on the relevance of ED potential of a substance for human health/environment

Value-added Services

In silico screening by QSAR experts

Bespoke services adapted to many domains

(biocides, PPP, cosmetics, chemicals…)

Experienced in-house (eco)toxicologists

Key Contact

Interested to know more? Our key contact for Endocrine Disruption services, Julien LEGHAIT will be happy to answer all your queries. You can email him or simply drop your query into the chat window below.



Coordinator of Endocrine Disruption services






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