Per- and polyfluoroalkyl substances (PFAS) are a large family of anthropogenic chemicals characterised by highly stable carbon–fluorine bonds. Structurally, PFAS typically contain at least one fully fluorinated methyl (CF₃-) or methylene (-CF₂-) carbon atom.

During our COSMETICK webinar on cosmetic safety assessment, toxicologists raised key questions on endocrine disruption, Margin of Safety (MOS), and toxicological data gaps.

Rôle du PIF dans la mise sur le marché  Dans l’Union Européenne, la mise sur le marché d’un produit cosmétique ne peut se faire sans un dossier complet que l’on appelle Product Information File (PIF) ou Dossier d’Information Produit (DIP) en français. Il s’agit d’une obligation légale définie par le Règlement (CE) n°1223/2009.  

The identification of endocrine disruptors (EDs) has become a key challenge for many industries. With increasing regulatory requirements and the growing number of substance lists evaluated by authorities, obtaining a clear and rapid overview of a substance’s status has become increasingly complex.

Since the sartans crisis in 2018, the detection of nitrosamines has highlighted systemic gaps in identifying contamination pathways across pharmaceutical supply chains. As impurities belonging to the “cohort of concern” following ICH M7 (R2), nitrosamines present exceptionally high carcinogenic potency.

Since 12 January 2026, the European Union has reached a major milestone in the protection of public health and water resources. The transition period provided for under Directive (EU) 2020/2184 (recast Drinking Water Directive) has now ended. 

The recent amendment to the European Cosmetic Regulation significantly expands the list of fragrance allergens that must be declared on the INCI label (Regulation (EU) No 2023/1545 updating certain entries of Annex III of the EU Cosmetic Regulation).  In the original version of Regulation (EC) No 1223/2009, 26 allergens were subject to mandatory labelling.

In December 2025, the European Commission published a targeted legislative proposal under its Food and Feed Safety Simplification Omnibus. One of its most relevant elements for the biocides sector is a proposed amendment to Regulation (EU) No 528/2012 (the Biocidal Products Regulation, or BPR), extending certain data protection periods for active substances still undergoing review.

The Annual Biocontrol Industry Meeting (ABIM) was held in Basel (Switzerland) from 20 to 22 October 2025, bringing together more than 2,000 international participants, including industrial stakeholders, scientific institutes, authorities, professional associations and consulting companies.

The use of any new cosmetic ingredient must be safe. That is a legal obligation according to Article 3 of the European Cosmetic Regulation and in other cosmetic-related laws and standards throughout the world, but also a moral one, as it would be unethical to place on the market a substance that is toxic, or whose toxicity is unknown and for which safe exposure cannot be demonstrated.

Learn how the EU Toy Safety Regulation 2025/2509 strengthens child protection, bans harmful chemicals, and ensures toy compliance across Europe.

Since 13 December 2024, all non-food consumer products in the EU must comply with GPSR (2023/988). Manufacturers and importers must assess risks, maintain technical documentation for 10 years, and notify dangerous products via the Safety Business Gateway. CEHTRA expert Anna Chelle explains how to ensure compliance and protect consumers.

On 13 January 2026, the European Commission’s Joint Research Centre (JRC) published a new report: “JRC technical proposal on EU harmonised waste sorting labels under the packaging and packaging waste regulation”.

COSMETICK is a toxicological and ecotoxicological profile database, combined with a digital cosmetic risk assessment tool. It is designed to support toxicologists and safety assessors in the preparation of Cosmetic Product Safety Reports (CPSR), as well as in the safety assessment of ingredients, impurities, raw materials and fragrance compounds or fragrance concentrates.

In 2025, CEHTRA continued its mission to support industrial companies, institutions and regulated stakeholders in a context marked by increasing regulatory complexity and growing challenges related to the protection of human health and the environment.

Ethylenediamine (EDA, CAS 107-15-3) is a chemical compound widely used as an intermediate in many industrial processes, such as chemical synthesis, resin manufacturing, chelating agents, and additives for lubricating oils. However, due to its hazardous properties, in particular its classification as a respiratory and skin sensitiser, EDA has been identified as a Substance of Very High Concern (SVHC).

In recent years, few regulatory topics have attracted as much attention as endocrine disruptors, chemicals capable of interfering with hormone systems in humans and wildlife. Their potential effects on development, reproduction, and environmental health have prompted increasingly rigorous scrutiny across the globe.

Ensure your cosmetic products are safe and compliant in the EU with a Cosmetic Product Safety Report (CPSR). Learn what it includes, who prepares it, and why it’s legally required under Regulation (EC) No 1223/2009.

La Directive (UE) 2020/2184 établit un cadre harmonisé destiné à garantir la sécurité des matériaux et des produits entrant en contact avec l’eau destinée à la consommation humaine. Pour atteindre cet objectif, elle introduit un dispositif central : les Listes Positives Européennes (EUropean Positive Lists, EUPL).

The REACH Regulation (EC No 1907/2006) aims to ensure a high level of protection for human health and the environment from the risks posed by chemical substances. Among its four main pillars, Registration, Evaluation, Authorisation and Restriction, the Authorisation process is often the most complex for non-specialists to understand. Yet it plays a critical role in managing the most hazardous substances on the European market.