Glabridine: An Ingredient Under Scrutiny in Cosmetics

1. Known Uses 

Glabridine is an isoflavonoid (isoflavane) extracted from Glycyrrhiza glabra (licorice root). It is widely used in cosmetics for its skin-lightening and anti-tyrosinase activity, as well as for its antioxidant and anti-inflammatory properties. It is mainly found in skincare products, anti-aging creams, and sunscreens. 📖 J Lui, 2025 ScienceDirect 

2. Mechanism of Action of Glabridine 

Glabridine inhibits tyrosinase, a key enzyme in melanin synthesis responsible for skin pigmentation. It acts as a reversible, non-competitive inhibitor, meaning it effectively reduces tyrosinase activity without directly binding to its active site. This inhibition occurs through a multi-phase kinetic process, suggesting the formation of a stable glabridine-tyrosinase complex. 📖 J Chen, 2016 PubMed 

3. Toxicological and Regulatory Concerns 

Available scientific data show efficacy in tyrosinase inhibition, but systemic toxicity studies remain limited. Points of caution include: 

• The potential estrogenic activity of certain isoflavones, an endocrine-disrupting effect observed in some tests, particularly in vitro, cannot be excluded (CIR Glycyrrhiza Glabra (Licorice), 2008) CIR Reports 

• Limited data on systemic toxicity and reproductive toxicity (EFSA, 2011) EFSA Journal 

Our view: Such effects and “data gaps” warrant further research. 

In the context of cosmetic regulations, having a detailed toxicological profile helps professionals anticipate and secure their formulations. 

To explore the complete profile of glabridine, visit our dedicated page: https://www.cehtra.com/cosmetick  

📢 And check out the associated LinkedIn post for a concise overview : https://lnkd.in/p/eSj7GxE5