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COSMETICK is a toxicological and ecotoxicological profile database, combined with a digital cosmetic risk assessment tool. It is designed to support toxicologists and safety assessors in the preparation of Cosmetic Product Safety Reports (CPSR), as well as in the safety assessment of ingredients, impurities, raw materials and fragrance compounds or fragrance concentrates.

In 2025, CEHTRA continued its mission to support industrial companies, institutions and regulated stakeholders in a context marked by increasing regulatory complexity and growing challenges related to the protection of human health and the environment.

Ethylenediamine (EDA, CAS 107-15-3) is a chemical compound widely used as an intermediate in many industrial processes, such as chemical synthesis, resin manufacturing, chelating agents, and additives for lubricating oils. However, due to its hazardous properties, in particular its classification as a respiratory and skin sensitiser, EDA has been identified as a Substance of Very High Concern (SVHC).

In recent years, few regulatory topics have attracted as much attention as endocrine disruptors, chemicals capable of interfering with hormone systems in humans and wildlife. Their potential effects on development, reproduction, and environmental health have prompted increasingly rigorous scrutiny across the globe.

Ensure your cosmetic products are safe and compliant in the EU with a Cosmetic Product Safety Report (CPSR). Learn what it includes, who prepares it, and why it’s legally required under Regulation (EC) No 1223/2009.

La Directive (UE) 2020/2184 établit un cadre harmonisé destiné à garantir la sécurité des matériaux et des produits entrant en contact avec l’eau destinée à la consommation humaine. Pour atteindre cet objectif, elle introduit un dispositif central : les Listes Positives Européennes (EUropean Positive Lists, EUPL).

The REACH Regulation (EC No 1907/2006) aims to ensure a high level of protection for human health and the environment from the risks posed by chemical substances. Among its four main pillars, Registration, Evaluation, Authorisation and Restriction, the Authorisation process is often the most complex for non-specialists to understand. Yet it plays a critical role in managing the most hazardous substances on the European market.

The Directive (EU) 2020/2184, adopted on December 16, 2020, marks a pivotal change in the management of drinking water across EU. It replaces the 1998 directive and aims to ensure universal access to safe and high-quality drinking water while enhancing transparency, monitoring, and risk management. This legislation has significant implications for water suppliers, industries dealing with materials in contact with water, as well as consultants and other stakeholders in the sec

Octocrylene is a widely used ultraviolet (UV) filter in cosmetic products, particularly sunscreens, designed to absorb UVB and part of the UVA spectrum, thereby protecting the skin against the harmful effects of sunlight. Currently, octocrylene is authorised in cosmetic products at a maximum concentration of 9% in accordance with Annex VI of the European Cosmetics Regulation...

L'apparition inattendue d'impuretés de N-nitrosamines dans les médicaments a marqué un tournant réglementaire majeur. Ces composés, connus dans l'environnement et l'alimentation, ont forcé l'industrie pharmaceutique mondiale à revoir ses processus. Face à cette situation, une coordination internationale sans précédent a vu le jour entre les agences réglementaires mondiales, telles que la FDA (États-Unis),

When a company develops a new ingredient, whether it is a concentrated plant extract, a biotech-derived ferment, a processed algae or a “functional” mushroom, one recurring question always arises: is a Novel Food procedure required before marketing the ingredient within the EU? This question often emerges when the project is already well advanced: the formulation is nearly finalized, the marketing identity is ready, the first commercial discussions have started…

The identification of endocrine disruptors (EDs) has become a major public health and environmental concern worldwide. EDs are chemical substances capable of interfering with the hormonal system, leading to adverse effects on both humans and wildlife. Monitoring and assessing these substances is essential to protect human health, particularly among vulnerable populations such as pregnant women, children, and wild species. To this end, the U.S. Environmental Protection Agen

Les substances per- et polyfluoroalkylées (PFAS) font l’objet d’une attention croissante des autorités européennes en raison de leur persistance, bioaccumulation et toxicité.Dans ce contexte, le secteur des produits phytopharmaceutiques (PPP) est désormais scruté de près à travers le rapport de restriction de l’Annexe XV de l’ECHA. Ce rapport indique que les substances actives utilisées dans les PPP, les produits biocides et les produits médicinaux se distinguent chimiquemen

At CEHTRA, regulatory expertise goes beyond compliance. Our strength lies in a human-driven, client-focused approach supported by collective intelligence and responsible scientific commitment.

Discover Cehtrawatch, the digital regulatory monitoring tool that keeps your business compliant with controlled updates and no software installation needed.

Learn what an endocrine disruptor is, how EDs are identified in the EU, and the regulatory criteria used under CLP, biocides, and pesticides. Discover how CEHTRA supports ED assessment and classification.

n-Hexane (CAS No. 110-54-3) is a volatile aliphatic hydrocarbon derived from petroleum distillation. Used as a solvent, it plays a key role in several sectors: Food industry: extraction of vegetable oils (soy, rapeseed, sunflower), flavors, and proteins. Cosmetics and perfumery: obtaining absolutes, essential oils, and pure plant extracts. Its popularity is based on its efficiency, high yield, and low cost. However, this solvent requires strict purification to limit res

Lorsqu’on parle de nutrition, de compléments alimentaires ou d’ingrédients innovants, le mot “naturel” inspire immédiatement confiance. Mais est-ce qu’un ingrédient naturel est toujours sûr pour la consommation ? Spoiler alert : pas nécessairement. Et c’est justement ce que les scientifiques et les experts en sécurité alimentaire s’attachent à démontrer, preuve à l’appui.

Glabridine is an isoflavonoid (isoflavane) extracted from Glycyrrhiza glabra (licorice root). It is widely used in cosmetics for its skin-lightening and anti-tyrosinase activity, as well as for its antioxidant and anti-inflammatory properties. It is mainly found in skincare products, anti-aging creams, and sunscreens.

HOMONOPAL, également connu sous le nom de Pinoacétaldéhyde, est un aldéhyde aromatique synthétique couramment utilisé dans les compositions parfumées. Son numéro CAS est 33885-51-7. Reconnu pour son odeur verte, florale et légèrement aldéhydée, ce composé apporte de la fraîcheur et de la vivacité aux accords parfumés, en particulier dans les parfums de luxe, les produits de soin personnel et les formulations de nettoyage.